Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit

Jansen, Diana; Peters, Esther; Heemskerk, Suzanne; Koster-Kamphuis, Linda; Bouw, Martijn P.W.J.M.; Roelofs, Hennie M.J.; Oeveren, Wim van; Heijst, Arno van; Pickkers, Peter

doi:10.1055/s-0035-1563714

Cited by 25 publications

(10 citation statements)

References 36 publications

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“…This finding is in accordance with other studies and may reflect an under-recognized tubular injury [19]. Jansen et al [20] describe an increased urinary excretion of different biomarkers after gentamicin administration in a neonatal population. This rise precedes the peak of serum creatinine and the decrease in urinary output.…”

Section: Discussionsupporting

confidence: 91%

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Mul

Parvex

Wilhelm-Bals

2021

The Journal of Maternal-Fetal & Neonatal Medicine

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Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as an early acute kidney injury (AKI) biomarker in the neonatal population. Our goal is to describe this biomarker behavior in this high-risk population, in absence of AKI as confirmed by inulin clearance. Materials and methods: Prospective study including 42 preterm newborns (mean gestational age: 30.7 ± 2.3 weeks) with a urinary NGAL collection between day 1 and 6 of life. Results: Median urinary neutrophil gelatinase-associated lipocalin (uNGAL) value is 122.8 ng/ml (7-1981.5 ng/ml). Statistically significant higher uNGAL values are found in female. uNGAL median values are decreasing when comparing extremely, very, and late preterm groups (812.2 ng/ml [75.

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Section: Discussionsupporting

confidence: 91%

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Mul

Parvex

Wilhelm-Bals

2021

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Creatinine undergoes glomerular filtration and tubular secretion to a lesser degree. Such elevated serum creatine levels can be associated with drug-induced oxidative alteration of mitochondrial or cytosolic creatine kinases, oxidative damage-prone enzymes 14 . Blood urea nitrogen is a metabolic waste product excreted in urine by the kidneys.…”

Section: Discussionmentioning

confidence: 99%

Some Physiological Effect of Acacia Gum on Acute Renal Failure Induced by Gentamicin in Male Rabbits

AL-Mousawi,

AL-rikabi,

AL-Hamed

2021

Indian Journal of Forensic Medicine & Toxicology

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Renal failure a case characterized by the impairment of the kidney to filter waste products from the body.The study aims to evaluate the potential effect of Acacia gum in the prevention of induced Acute renal failure in the rabbit model. Eighteen healthy male domestic rabbits (Lepus cuniculus) were divided into three groups. Group 1: normal rabbits as control, Group 2: animals were injected (70mg/kg. B.W) of intramuscular gentamicin daily for 14 days for induction of acute renal failure, Group 3: animals were treated with intramuscular injection (70mg/kg B.W) gentamicin daily and offered 15% Acacia gum with drinking water for 14 days. At the end of the experiment Serum urea, uric acid, creatinine, blood urea nitrogen, calcium, sodium, and malondialdehyde were measured in addition to Urine analysis. The results showed that the treatment of Acacia gum improved significantly serum uric acid, creatinine, urea, blood urea nitrogen, electrolyte, and proteinuria. Also reduced malonaldehyde, urine Specific gravity, and pH levels. Our findings conclude that GA can protect the kidney by enhancing antioxidant efficiency, and may be useful in improving acute renal failure.

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“…Recent studies have evaluated the impact of AG on urinary markers of proximal tubule damage. These studies have shown that AG exposure results in the elevation of urinary biomarkers, including those that signify proximal tubular damage, irrespective of rise in serum creatinine [31**,35*,36]. These data suggest there may be damage resulting from AG exposure that is not detected by a rise in serum creatinine, which warrants further study.…”

Section: Nephrotoxic Medicationsmentioning

confidence: 99%

Drug-induced acute kidney injury in neonates

Hanna

Askenazi

Selewski

2016

Current Opinion in Pediatrics

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Purpose of review Acute kidney injury (AKI) is an independent risk factor for morbidity and mortality in critically ill neonates. Nephrotoxic medication exposure is common in neonates. Nephrotoxicity represents the most potentially avoidable cause of AKI in this population. Recent findings Recent studies in critically ill children revealed the importance of recognizing AKI and potentially modifiable risk factors for the development of AKI such as nephrotoxic medication exposures. Data from critically ill children who have AKI suggests that survivors are at risk for development of chronic kidney disease. Premature infants are born with incomplete nephrogenesis and are at risk for chronic kidney disease (CKD). The use of nephrotoxic medications in the neonatal intensive care unit (NICU) is very common; yet the effects of medication nephrotoxicity on the short and long-term outcomes remains highly understudied. Summary The neonatal kidney is predisposed to nephrotoxic AKI. Our ability to improve outcomes for this vulnerable group depends on heightened awareness of this issue. It is important for clinicians to develop methods to minimize and prevent nephrotoxic AKI in neonates through a multi-disciplinary approach aiming at earlier recognition and close monitoring of nephrotoxin induced AKI.

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Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit

Abstract: GM administration to neonates is associated with renal damage reflected by a more pronounced increase in sCr preceded by urinary excretion of biomarkers. Urinary biomarkers may be useful for earlier identification of renal injury in neonates.

Cited by 25 publications

References 36 publications

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Some Physiological Effect of Acacia Gum on Acute Renal Failure Induced by Gentamicin in Male Rabbits

Drug-induced acute kidney injury in neonates

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