Some Physiological Effect of Acacia Gum on Acute Renal Failure Induced by Gentamicin in Male Rabbits

Abstract

Renal failure a case characterized by the impairment of the kidney to filter waste products from the body.The study aims to evaluate the potential effect of Acacia gum in the prevention of induced Acute renal failure in the rabbit model. Eighteen healthy male domestic rabbits (Lepus cuniculus) were divided into three groups. Group 1: normal rabbits as control, Group 2: animals were injected (70mg/kg. B.W) of intramuscular gentamicin daily for 14 days for induction of acute renal failure, Group 3: animals were treated with intramuscular injection (70mg/kg B.W) gentamicin daily and offered 15% Acacia gum with drinking water for 14 days. At the end of the experiment Serum urea, uric acid, creatinine, blood urea nitrogen, calcium, sodium, and malondialdehyde were measured in addition to Urine analysis. The results showed that the treatment of Acacia gum improved significantly serum uric acid, creatinine, urea, blood urea nitrogen, electrolyte, and proteinuria. Also reduced malonaldehyde, urine Specific gravity, and pH levels. Our findings conclude that GA can protect the kidney by enhancing antioxidant efficiency, and may be useful in improving acute renal failure.