Tubular and glomerular biomarkers of renal tissue function in the urine of fetuses with posterior urethral valves

Bastos, Fernando Macedo; Leal, Caio Ribeiro Vieira; Castro, Pedro Alves Soares Vaz de; Vaz, Katarina Keyla Brito; Oliveira, Kamila Ketlen Rodrigues de; Filha, Roberta da Silva; Pereira, Alamanda Kfoury; Silva, Ana Cristina Simões e

doi:10.1016/j.jpurol.2022.03.019

Cited by 1 publication

(3 citation statements)

References 31 publications

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“…Soluble markers of renal disease in urine, despite numerous analyses, remain without correlation with a specific disease entity [17]; rather, they are markers of pathophysiological processes [2,[18][19][20][21]. Among the most commonly included proteins in ongoing studies are: NGAL, TGFβ1, MCP1, EGF, KIM-1 [2,4,18,21,22].…”

Section: Specifics Of Kidney Disorders In Children Andmentioning

confidence: 99%

“…There are a large number of papers available in the field of pediatric nephro-urology assessing the whole urine proteome in the disease entities discussed in this review [19,20,2,18,21]. The most commonly described biomarkers include: NGAL, TGFβ1, MCP1, EGF, KIM-1 [4,2,18,21,22].…”

Section: Small Extracellular Vesicles In Pediatric Nephrology: Hopes ...mentioning

confidence: 99%

“…Proteins can be released from cells either directly (as soluble, slowly circulating forms) or with vesicular transport, which has the advantage of avoiding an adaptive immune response [10, 14]. Soluble markers of renal disease in urine, despite numerous analyses, remain without correlation with a specific disease entity [17]; rather, they are markers of pathophysiological processes [2, 18–21]. Among the most commonly included proteins in ongoing studies are: NGAL, TGFβ1, MCP1, EGF, KIM‐1 [2, 4, 18, 21, 22].…”

Section: Extracellular Vesicles (Ev) As a New Tool In The Diagnosis O...mentioning

confidence: 99%

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Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

Korecka,

Gawin,

Pastuszka

et al. 2024

Proteomics

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The primary function of the kidneys is to maintain systemic homeostasis (disruption of renal structure and function results in multilevel impairment of body function). Kidney diseases are characterized by a chronic, progressive course and may result in the development of chronic kidney disease (CKD). Evaluation of the composition of the proteome of urinary small extracellular vesicles (sEVs) as a so‐called liquid biopsy is a promising new research direction. Knowing the composition of sEV could allow localization of cellular changes in specific sections of the nephron or the interstitial tissue before fixed changes, detectable only at an advanced stage of the disease, occur. Research is currently underway on the role of sEVs in the diagnosis and monitoring of many disease entities. Reports in the literature on the subject include: diabetic nephropathy, focal glomerulosclerosis in the course of glomerulopathies, renal fibrosis of various etiologies. Studies on pediatric patients are still few, involving piloting if small groups of patients without validation studies. Here, we review the literature addressing the use of sEV for diagnosis of the most common urinary disorders in children. We evaluate the clinical utility and define limitations of markers present in sEV as potential liquid biopsy.

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Section: Specifics Of Kidney Disorders In Children Andmentioning

confidence: 99%

Section: Small Extracellular Vesicles In Pediatric Nephrology: Hopes ...mentioning

confidence: 99%

Section: Extracellular Vesicles (Ev) As a New Tool In The Diagnosis O...mentioning

confidence: 99%

See 1 more Smart Citation

Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

Korecka,

Gawin,

Pastuszka

et al. 2024

Proteomics

View full text Add to dashboard Cite

show abstract

Tubular and glomerular biomarkers of renal tissue function in the urine of fetuses with posterior urethral valves

Cited by 1 publication

References 31 publications

Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

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