Tubular Adenoma of the Main Pancreatic Duct

Shahinian, Hrayr K.; Sciadini, Marcus F.; Springer, Douglas J.; Reynolds, Vernon; Lennington, Wayne J.

doi:10.1001/archsurg.1992.01420100120022

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…According to General Rules for the Study of Pancreatic Cancer by the Japan Pancreatic Society, ITT is defined as consisting of dense and uniform atypical tubular glands with scant mucus 11 . Based on a MEDLINE search from 1980 through 2005, nine ITC 1–3 and 13 ITA 4–10 (Tables 1,2) have been reported. All nine ITC have unique characteristics of intraductal nodular growth, occupying the MPD without macroscopic mucus, although two of nine ITC were described as papillotubular adenocarcinoma 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, variants of intraductal tumors of the pancreas with tubular architecture or scant mucin production have been described. [1][2][3][4][5][6][7][8][9][10] According to General Rules for the Study of Pancreatic Cancer by the Japan Pancreas Society, the intraductal tumors of the pancreas are divided into intraductal papillary-mucinous tumors (IPMT) and intraductal tubular tumors (ITT). 11 The latter is defined as consisting of dense and uniform atypical tubular glands with scant mucus.…”

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confidence: 99%

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Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: Dilemma in classification

Hisa¹,

Nobukawa

Suda

et al. 2007

Pathology International

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An 84-year-old man, who was being followed up after lobectomy for lung carcinoma, was referred for evaluation of a dilated main pancreatic duct (MPD) from the body to the tail. Endoscopic ultrasonography demonstrated a low-echo mass occupying the MPD from the body to the tail. Endoscopic retrograde pancreatography showed an occlusion of the MPD in the body, and brush cytology indicated malignant cells. Distal pancreatectomy was performed. Grossly, a white-yellow, irregular-shaped solid mass without macroscopic mucus filled the lumen of the MPD. Histologically, the mass consisted of a complex fusion of tubular glands with atypical nuclei, which did not have intracellular mucus and oncocytic cytoplasm. The tumor mass showed abrupt transition to the normal epithelium. Immunohistochemically the tumor cells were partially positive for mucin 1 (MUC1) and MUC6, and negative for MUC2, MUC5AC, and lipase. Unfortunately the patient died of brain metastasis from lung carcinoma 15 months later. A review of reported cases of intraductal tubular tumors of the pancreas showed that the present case involved characteristics and immunohistochemical staining pattern similar to those of intraductal tubular carcinoma, although it might not be described as a typical intraductal tubular carcinoma under the existing Japanese rules.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: Dilemma in classification

Hisa¹,

Nobukawa

Suda

et al. 2007

Pathology International

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“…1 It has been reported that ITPN is distinct from intraductal papillary mucinous neoplasm (IPMN) because of the lack of mucin production, presence of tubule formation, uniformly high-grade nuclear atypia, different immunohistochemical profiles, and distinct genetic profiles. 2 Shahinian et al 3 described the first case of intraductal neoplasm with tubular configuration, and they named it ''tubular adenoma of the main pancreatic duct'' in 1992. Tajiri et al 4 described a malignant form of ''intraductal tubular neoplasm of the pancreas'' and reported it as intraductal tubular carcinoma.…”

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Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview

Kim¹,

2018

Archives of Pathology &Amp; Laboratory Medicine

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Intraductal tubulopapillary neoplasm is a rare tumor that the World Health Organization recognized in 2010 as a subtype of premalignant pancreatic neoplasms. It is important to distinguish it from other intraductal neoplasms, including intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, and intraductal variant of acinar cell carcinoma, because intraductal tubulopapillary neoplasm has a favorable prognosis. Histopathologically, intraductal tubulopapillary neoplasms are characterized by tubulopapillary growth, uniform high-grade cytologic atypia, frequent necrotic foci, evident ductal differentiation, and absence of mucin. Intraductal tubulopapillary neoplasms show distinct immunohistochemical and molecular findings, with positive cytokeratin 7, cytokeratin 19, MUC1, and MUC6, and somatic PIK3CA mutations (2 of 11; 18%), and low rates of KRAS (2 of 20; 10%), TP53 (5 of 22; 23%), and BRAF (2 of 13; 15%) mutations. These differences also highlight the fact that intraductal tubulopapillary pancreatic neoplasm is distinct from other similar neoplasms.

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“…In 1992, Shahinian et al 24 first reported a case of tubular adenoma of the duct of Wirsung with focal villous changes in a 69-year-old woman. In 1992, Shahinian et al 24 first reported a case of tubular adenoma of the duct of Wirsung with focal villous changes in a 69-year-old woman.…”

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“…In 1992, Shahinian et al 24 first reported a case of tubular adenoma of the duct of Wirsung with focal villous changes in a 69-year-old woman. To date, only 5 cases of ITA have been reported in the English literature, 4,6,13,24 with one of them being identified in Japan. Albores-Saavedra et al 4 recently reported 3 cases, including the previously reported one of Bakotic et al 6 of an intraductal tubular adenoma, pyloric type, of the main pancreatic duct.…”

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Intraductal Tubular Adenoma of the Pancreas, Pyloric Gland Type

Nakayama¹,

Inoue²,

Hamada³

et al. 2005

American Journal of Surgical Pathology

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The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder. We report 6 cases of ITA of the pancreas: 3 male and 3 female aged 50 to 79 years (mean, 63.5 years; median, 65 years); all were examined clinicopathologically. Four patients showed no symptoms, but appetite loss and/or general fatigue presented in two. Grossly, all tumors formed a localized polypoid mass protruding into the lumen of the dilated pancreatic duct. Five of the six tumors were found within the main duct, and the other arose within the branch duct of the pancreas. Microscopically, the tumors were composed of closely packed tubular glands resembling pyloric type glands. They were lined by columnar or cuboidal epithelial cells with foci of mild to moderate dysplastic change. In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous adenoma. Histochemically, the tumors largely showed neutral mucin with a lesser amount of acidic mucin made up mainly of sialomucin. Endocrine cells were found in five tumors. Immunohistochemically, all tumors were labeled with M-GGMC-1 and MUC6, whereas MUC1 and MUC2 stains were negative. Pepsinogen II was positive in 5 tumors; thus, the results displayed a pattern of differentiation similar to those of ordinary gastric pyloric or metaplastic pyloric glands. DPC4 expression was maintained in all tumors and p53-positive nuclei were hardly encountered. All patients are alive with no evidence of disease 3 to 10.5 years after surgical resection.

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Tubular Adenoma of the Main Pancreatic Duct

Cited by 15 publications

References 4 publications

Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: Dilemma in classification

Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: Dilemma in classification

Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview

Intraductal Tubular Adenoma of the Pancreas, Pyloric Gland Type

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