Tuberous Sclerosis With Psychosis

Atypical presentation of tuberous sclerosis and obsessive compulsive disorder in an adult male

“…It is clinically recognized by a triad comprising of adenoma sebaceum, epilepsy and mental retardation, with an autosomal-dominant inheritance,[ 1 ] affecting mainly two genes – hamartin (9q) and tuberin (16p). Subjects affected by TSC may manifest various neuropsychiatric disorders like psychosis,[ 2 ] hyperkinesis, aggression and autism in children,[ 3 ] and even mood disorders like mania. [ 4 ] In addition, several other neurpsychiatric comorbidities have been reported, which include schizophrenia, Capgras’ syndrome, psychosis, auditory hallucinations, mania, anorexia nervosa and alcohol dependence.…”

Acute Psychosis and Epileptic Encephalopathy as a Preliminary Symptom Leading to the Diagnosis of Tuberous Sclerosis Complex in an Adolescent

“…In literature, a case was reported responding well to risperidone without side effects [13]. Our patient's psychotic symptoms progressed while he was on risperidone and he had extrapyramidal side effects.…”

“…There is not a specific treatment for psychosis seen in TSC [13,14]. In literature, a case was reported responding well to risperidone without side effects [13].…”

Obsessive compulsive disorder in a patient with tuberous sclerosis and subependymal giant cell astrocytoma

“…Most important cutaneous findings are hypomelanotic macules usually present at birth, café-au-lait macules, facial angiofibromas, shagreen patchs, periungual fibromas (Koenen tumors), molluscum pendulum, gingival fibromas and enamel pits. [4,8] Our patient has multiple angiofibromas on the face and multiple hypomelanotic maculas on the dorsum and legs. In TSC the most important neurologic findings are infantile spasms, hypsarrhythmia, seizures, autism, attention deficit disorders, psychoses, multiple calcified subependymal nodules along the ventricular surface, subependymal giant cell astrocytomas, multiple cortical tubers.…”

“…[3] TSC may manifest with many neuropsychiatric disorders. The most common are psychosis, [4] aggressive behavior and autism in children, [5] and mood disorders in adults. [6] Besides, many other neuropsychiatric problems have been reported, including psychotic syndromes, mania, eating disorders, and alcohol dependence.…”