Obsessive compulsive disorder in a patient with tuberous sclerosis and subependymal giant cell astrocytoma

Abstract

Tuberous sclerosis complex (TSC) is a multi-system disorder with autosomal dominant inheritance, which can affect the brain, heart, skin, kidneys, lungs, and retina. We present an obsessive-compulsive disorder patient, with classic dermatological findings and subependymal giant cell astrocytoma in TSC.

Comorbid obsessive compulsive disorder in a child with tuberous sclerosis complex

“…Recently, bumetanide, Na-K-2Cl transporter antagonist, was used in a patient with TSC accompanied with a variety of repetitive and compulsive behaviors on the basis of the disrupted chloride homeostasis mechanism (18). In another case with TSC, improvement in the symptoms of OCD after giant cell astrocytoma operation was reported (19). Diversity of the lesion distribution of tuberous sclerosis patients may cause each patient to display a wide variety of psychiatric diseases in the clinic.…”