Tuberculous meningits in adults in Turkey: Epidemiology, diagnosis, clinic and laboratory

Hoşoğlu, Salih; Geyik, MF; Balık, İsmail; Aygen, Bilgehan; Erol, Serpil; Aygencel, Gülbin; Mert, Ali; Saltoğlu, Neşe; Dökmetaş, İlyas; Felek, Süleyman; Sumbul, M; Irmak, Hatice Selin; Aydín, Kadriye; Ayaz, Celal; Kökoğlu, O F; Uçmak, Hasan; Satilmis, S

doi:10.1023/a:1023673532656

Cited by 36 publications

(37 citation statements)

References 19 publications

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“…It was followed by 41 to 50 years affecting 28 (68.3%) of 41 cases, though this difference was not found statistically significant with p value of 0.24. Similar higher percentages were seen in other studies by Hoşoğlu S, Anderson NE and Molavi et al [14][15][16] But they used slight different age groups like 25 to 40 years where higher number of TBM was found. Why this age group was found more vulnerable to disease is not known.…”

Section: Discussionsupporting

confidence: 88%

Frequency of Hydrocephalus in Cases of TBM

Raza¹,

Rashid²,

Yasmeen³

2017

APMC

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Tuberculosis meningitis (TBM) is a serious public health problem in developing countries as it leads to significant mortality and residual neurological squeal. The estimated mortality due to TBM in Asia is 1.5 per 100,000 populations. Objectives: To determine the frequency of hydrocephalus in cases of TBM. Methodology: This was a cross sectional study conducted during July 2016 to December 2016 conducted at Department of Medicine Services Hospital, Lahore. The detailed demographic data was collected. Cases fulfilling the criteria of TBM underwent CT scan of brain (with IV contrast) for confirmation of TBM at the Department of Radiology, Sheikh Zayed hospital Rahim Yar Khan. Results: In this study there were 93 cases, out of which 54 were males and 39 females with mean of 34.13±9.45 years. Hydrocephalus was seen in 61 (65.59%) out of 93 cases of TBM. It was seen significantly higher in male group where it caused it in 40 out of 54 males (74.1%) with p value of 0.04 (table 1). In context of age groups with respect to hydrocephalus it was seen maximum in patients with age group of 31 to 40 years affecting 12 (80%) out of 15 of its respective group. It was followed by 41 to 50 years affecting 28 (68.3%) of 41 cases, though this difference was not found statistically significant with p value of 0.24. Hydrocephalus was observed maximum in stage I of TBM where it affected 4 out of 5 cases followed by stage II with 36 of 52 cases and then stage III with 21 of 36 patients. This difference was also not significant with p= 0.44. Conclusion: Hydrocephalus is an important and deadly complication of tuberculous meningitis and is noted in every 2 (65.59%) out of 3 cases. There is significant association of male gender with hydrocephalus.

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Section: Discussionsupporting

confidence: 88%

Frequency of Hydrocephalus in Cases of TBM

Raza¹,

Rashid²,

Yasmeen³

2017

APMC

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“…[43][44][45] Diagnosis of TB meningitis is usually by cerebrospinal fluid (CSF) examination including microscopy and culture. Microscopy has a low sensitivity, varying from 20 to 58%.…”

Section: Central Nervous System -Tuberculous Meningitismentioning

confidence: 99%

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

530

361

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“…7,8,11,[13][14][15][16][17] Bi zim ça lış ma mız da ise ABM 'ler de 42.7, TBM'de 42.1, VM'de 36.9 yıl ola rak sap tan dı. Bu du rum top lum kö ken li me nen jit/me nin go en se fa lit le rin ak tif, üret ken çağ da ki po pü las yo nu et ki le di ği ni gös ter mek te dir.…”

Section: Tar Tiş Maunclassified

Community Acquired Meningitis/Meningoencephalitis: Retrospective Evaluation of Five Years

Demıroğlu¹,

Turunç²,

Alışkan³

et al. 2010

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma kli ni ği miz de iz le di ği miz me nen jit / me nin go en se fa lit ol gu la rı nın eti yo lo jik fak tör le rini, mor bi di te si ni, fa ta li te oran la rı nı ve ma li ye ti ni de ğer len dir mek, ül ke miz ve dün ya ve ri le riy le kar şı laş tır mak ama cıy la ya pıl dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Kli ni ği miz de Ni san 2003-Ma yıs 2008 ta rih le ri ara sın da iz le nen 51 eriş kin me nen jit/me nin go en se fa lit ol gu su ret ros pek tif ola rak de ğer len di ril di. Has ta la rın de mog ra fik özel lik le ri ve kli nik bil gi le ri has ta dos ya la rın dan el de edil di. Me nen jit/me nin go en se fa lit ta nı sı uy gun kli nik bul gu lar var lı ğın da, beyin omurilik sıvısı (BOS) in ce le me le ri ve ge rek ti ğin de gö rün tü le me yön tem le ri ile ko nul du. B Bu ul l g gu u l la ar r: : El li bir ol gunun 29'una (%56.9) akut bak te ri yel me nen jit, 12'si ne (%23.5) vi ral me ne nin go en se fa lit, 10'una (%19.6) tü berkü loz me nen jit ta nı sı ko nul du. Me nen ji tin kla sik bul gu la rı olan ateş, en se sert li ği ve bi linç de ği şik li ği akut bak te ri yel me nen jit ol gu la rı nın %69'un da, vi ral me nin go en se fa lit ol gu la rı nın %50'sin de, tü ber kü loz me nen jit ol gu la rı nın %40'ın da sap tan dı. Kan be yaz kü re sa yı sı akut bak te ri yel me nen jit ol gu la rın da 19.308/mm³, vi ral menin go en se fa lit ol gu la rın da 10.389/mm³, tü ber kü loz me nen jit ol gu la rın da 9980/mm³ ola rak tes pit edil di. Akut bak te ri yel me nen jit ol gu la rın da kan be yaz kü re sa yı sı nın yük sek ol ma sı is ta tis tik sel ola rak an lam lıy dı (p< 0.05). Akut bak te ri yel me nen jit ol gu la rın da be yin-omu ri lik sı vı sın da lö ko sit sa yı sı 4254.0/mm³ iken, vi ral me nin go ense fa lit ler de 282.5/mm³, tü ber kü loz me nen jit te 365/mm³ ola rak sap tan dı. Akut bak te ri yel me nen jit ile iz le nen 29 ol gu nun 15'in de (%51.7) et ken izo le edil di; 10'un da (%34.4) Streptococcus pneumoniae, üçün de (%10.34) Listeria monocytogenes, birin de (%3.4) Staphylococcus aureus, birin de (%3.4) Streptococcus pyogenes. Tü ber kü loz menen jit ta nı sı ile iz le nen 10 ol gu nun ikisin de (%20) BOS kül tü rün de Mycobacterium tuberculosis üre til di. Vi ral menin go en se fa lit ta nı sı ile iz le nen 12 has ta nın 2'si nin BOS 'un da PCR ile HSV-DNA tip 1 po zi tif bu lun du. Top lum kö ken li me nen jit/me nin go en se fa lit ol gu la rın da or ta la ma has ta ne de ya tış sü re si 17.76 gün sap tan dı. Tü ber kü loz me nen jit ol gu la rın da ya tış sü re si an lam lı ola rak da ha uzun du (p< 0.05). Top lum me nen jit/me nin go en se fa lit ol gula rın da or ta la ma 4860.95 USD ilaç ve has ta ne mas ra fı na yol aç tı ğı tes pit edil di. Vi ral me nin go en se fa lit ol gu la rın -da ölüm göz len mez ken, akut bak te ri yel me nen jit te ol gu fa ta li te ora nı %37.9 (11/29), tü ber kü loz me nen jit te %10 (1/10) ola rak sap tan dı. Vi ral me nin go en se fa lit li üç, akut bak te ri yel me nen jit l...

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Tuberculous meningits in adults in Turkey: Epidemiology, diagnosis, clinic and laboratory

Cited by 36 publications

References 19 publications

Frequency of Hydrocephalus in Cases of TBM

Frequency of Hydrocephalus in Cases of TBM

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Community Acquired Meningitis/Meningoencephalitis: Retrospective Evaluation of Five Years

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