Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment

Jindal, Surinder K.; Aggarwal, Amita; Gupta, Dheeraj; Ahmed, Zaid K.; Gupta, K. B.; Janmeja, Ashok Kumar; Kashyap, Sangeeta R.; Singh, Meenu; Mohan, Aparna; Whig, J

doi:10.5588/ijtld.12.0333

Cited by 5 publications

(7 citation statements)

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“…In the study done by Jindal et al ., it was shown that 6 months therapy of DOTS is sufficient, and there is no benefit of prolonging the treatment for 9 months in cases of tuberculous lymphadenopathy. 21 Our study showed paradoxical increase in the size of the lymph node in 24 (11.8%) patients. However, these patients after completion of treatment showed complete resolution of their enlarged lymph node.…”

Section: Discussionmentioning

confidence: 46%

“…These cases may be considered the cured case because the size of lymph node was reduced to <1 cm. 21 Still they were followed for 6 months to detect any relapse. There was no increase in the size of lymph node noted.…”

Section: Discussionmentioning

confidence: 99%

“…Alternative diagnostic and treatment approaches including the surgery should be considered in such cases. 21 There is controversial role of steroid in the paradoxical upgrading reaction. Steroids had shown to reduce the paradoxical upgrading reaction.…”

Section: Discussionmentioning

confidence: 99%

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Tuberculous lymphadenopathy: Experience from the referral center of Northern India

Singh

Tiwari

2016

Niger Med J

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Background:Lymphadenopathy is the common form of extrapulmonary tuberculosis (TB) in the developing country like India. The aim of the study was to assess the clinical and the pathological features of tuberculous peripheral lymphadenopathy along with the effect of the antitubercular drugs on its clinical course.Materials and Methods:A prospective study was carried out in the department of pulmonary medicine from July 2013 to June 2014. Clinico-demographical and pathological characteristics of the patients of tuberculous lymphadenopathy were studied.Results:Two and four cases, 84 (41.2%) male and 120 (58.8%) females were diagnosed as the cases of tuberculous lymphadenopathy. Mean age of the patients were 28.45 ± 12.83. Palpable mass (100%) was the most common presenting feature. Cervical lymphadenopathy (92.6%) was the most common presentation of peripheral tuberculous lymphadenopathy. Most common cytological pattern seen was epithelioid granuloma with caseous necrosis (32.84%) followed by epithelioid granuloma without caseous necrosis on fine needle aspiration cytology (FNAC). Directly observed treatment short course (DOTS) for TB was effective in treating tuberculous lymphadenopathy.Conclusion:Tuberculous lymphadenopathy affects female more often than males. FNAC is the effective mean in diagnosing tuberculous lymphadenopathy. DOTS is the effective mean for treating tuberculous lymphadenopathy.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

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Tuberculous lymphadenopathy: Experience from the referral center of Northern India

Singh

Tiwari

2016

Niger Med J

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“…Upto 25% patients experience a paradoxical deterioration usually manifest as enlargement of the existing nodes irrespective of HIV infection or ART 20 . In study done by Chahed H et al at Tunisia, paradoxical reaction was reported in (13.4%) patients 21 …”

Section: Discussionmentioning

confidence: 99%

Treatment outcome of tuberculous lymphadeniti

Gaikwad¹,

Gaikwad²,

Thakur³

2017

Int J Recent Sci Res

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“…Surgical intervention can resolve complaints such as pain and may be helpful to shorten treatment duration and reduce relapse rate. However, some studies reported that stable or worsened LN during treatment was naturally regressed in most patients despite extended treatment duration [89]. Surgical intervention frequently results in a large scar that may be a permanent cosmetic problem.…”

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confidence: 99%

Is the Initial Size of Tuberculous Lymphadenopathy associated with Lymph Node Enlargement during Treatment?

Seol

Park

et al. 2017

Infect Chemother

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There are little data on the changes in lymph node (LN) size during the treatment of tuberculous lymphadenopathy (TB LAP). This study aimed to provide data on LN changes during treatment. Between March 2014 and December 2015, 20 patients who were diagnosed with cervical TB LAP were enrolled. LN enlargement within two months (50%, 4/8 vs. 8.3%, 1/12; P = 0.04) was more frequently observed in patients with initial LN size ≥ 7.5 cm2. Enlarged LNs were excised in three patients owing to pain and fistula formation. Initial LN size may be associated with LN enlargement during treatment.

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Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment

Abstract: The operational efficacy of 6-month thrice-weekly DOT for peripheral tubercular lymphadenopathy was satisfactory. There was no evidence of additional benefits of prolonging treatment to 9 months.

Cited by 5 publications

References 0 publications

Tuberculous lymphadenopathy: Experience from the referral center of Northern India

Tuberculous lymphadenopathy: Experience from the referral center of Northern India

Treatment outcome of tuberculous lymphadeniti

Is the Initial Size of Tuberculous Lymphadenopathy associated with Lymph Node Enlargement during Treatment?

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