Tuberculous encephalopathy with and without meningitis clinical features and pathological correlations

Udani, P. M.; Dastur, Darab K.

doi:10.1016/0022-510x(70)90187-5

Cited by 87 publications

(53 citation statements)

References 7 publications

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“…In contrast to tuberculomas in adults where two thirds are supra-tentorial, two thirds of the tuberculomas in children are infra-tentorial [4]. However, all our patients had sub-cortical, supra-tentorial lesions.…”

Section: Discussioncontrasting

confidence: 70%

Early Diagnosis of Intracerebral Tuberculoma in Children

Sharma

Gupta

Singh

1995

Medical Journal Armed Forces India

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Section: Discussioncontrasting

confidence: 70%

Early Diagnosis of Intracerebral Tuberculoma in Children

Sharma

Gupta

Singh

1995

Medical Journal Armed Forces India

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“…Atypical presentations include acute, rapidly progressive meningitic syndrome suggesting pyogenic meningitis; slowly progressive dementia occurring over a period of months to years; and an encephalitic course without overt signs of meningitis. 3 The clinical presentation in our patient was compatible with acute bacterial meningitis.…”

Section: Discussionmentioning

confidence: 57%

An 11-Year-Old Boy with Headache, Fever, and Neck Pain

Yış¹,

Polat²,

Karaoğlu³

et al. 2015

Pediatr Ann

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A n 11-year-old-boy was admitted to the pediatric emergency department with 5 days of headache that was bilateral, throbbing, and progressively worsening. It was associated with fever, vomiting, neck pain, and stiffness. He was previously diagnosed as having acute sinusitis, given oral amoxicillin, and discharged from the hospital. Prior to his presentation he was a healthy boy and had no history of headache, chronic illness, recent vaccinations, cutaneous rash, cough, diarrhea, arthralgia, or myalgia. He had two scars of Bacille Calmette-Guerin (BCG) vaccine. Axillary temperature on admission was 38.5°C.On physical examination, his weight and height were 33.5 kg and 145 cm, respectively. His mental status was alert and attentive. He had meningismus with increased deep tendon reflexes. There were no papilledema or focal neurologic signs. Cerebrospinal fluid (CSF) had a white blood cell count of 170/mcL (neutrophil predominant); protein of 89.1 mg/dL (normal range, 15-40 mg/dL); and glucose of 33 mg/dL (CSF to serum glucose ratio of 0.33). Computed tomography (CT) scan of the head on the day of admission was normal. Acute bacterial meningitis was suspected, so ceftriaxone (100 mg/kg per day) and vancomycin (60 mg/kg per day) were administered. The patient had four generalized convulsions on the first day of hospitalization, and he developed diplopia with increased headache intensity.Neurologic examination revealed left abducens nerve palsy. Magnetic resonance imaging with gadolinium contrast was normal. Chest radiograph was clear. CSF gram stain, cultures and acid fast bacilli smear, purified protein derivative (PPD) test, and blood and urine cultures were all negative. On the second day of hospitalization, he began to show signs of increased intracranial pressure with papilledema. His mental status was still alert.

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“…[11] Onset: In the present study, the onset is acute in 28% and subacute in 32% and insidious in 40% in adults. (Udani PK 1970). [12] Fever: Fever was observed invariably in all paients 97.4%.…”

Section: Discussionmentioning

confidence: 99%

“…In the present series 2 patients (1.8%) had obstructive hydrocephalus and 2 patients (1.8%) had communicating hydrocephalus. 20 -30% may develop cranial nerve palsies (Udani PK et al 1970). [12] The sixth nerve is the most affected followed by third, fourth and seventh.…”

Section: Discussionmentioning

confidence: 99%

A Study on Clinical Analysis of Central Nervous System Tuberculosis in Adults and Treatment Outcome

Narayanan¹,

Madhavan²,

Anandan³

2017

AIMDR

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Background: Tuberculosis of the central nervous system (CNS) is a highly devastating form of tuberculosis, which, even in the setting of appropriate antitubercular therapy, leads to unacceptable levels of morbidity and mortality. Aim: To study the various clinical presentations of Central Nervous System Tuberculosis, complication, morbidity and mortality and various types of treatment modalities and their outcome. Methods: 240 patients with CNS-TB were included in the study. Detail history of any prior antituberculous treatment, their duration, and regimen was enquired. A thorough general examination was made including pulse, blood pressure, skeletal system, skin, and eye. Nervous system was examined in detail looking for signs of meningeal irritation and focal neurological deficit. Results: 19 patients (63.3%) were tuberculous meningitis, 7 patients (28.3%) were tuberculoma of the brain, 2 patients (6.6%) were tuberculous Arachnoiditis, and 2 patients were Pott's paraplegia (6.6%). In TBM patients, who had presented as 'Aseptic Meningitis' form had food recovery without any sequelae. In this series, complete recovery was 66.6% mortality was 13.3% and sequelae in 20%. Patients treated with Pyrazinamide had its full effect during first 2 months of treatment and had a good recovery. Conclusion: Timely diagnosis of central nervous system tuberculosis is of key importance because delayed treatment is associated with higher morbidity and mortality.

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Tuberculous encephalopathy with and without meningitis clinical features and pathological correlations

Cited by 87 publications

References 7 publications

Early Diagnosis of Intracerebral Tuberculoma in Children

Early Diagnosis of Intracerebral Tuberculoma in Children

An 11-Year-Old Boy with Headache, Fever, and Neck Pain

A Study on Clinical Analysis of Central Nervous System Tuberculosis in Adults and Treatment Outcome

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