Tuberculosis treatment outcomes in Ethiopia from 2003 to 2016, and impact of HIV co-infection and prior drug exposure: A systematic review and meta-analysis

Eshetie, Setegn; Gizachew, Mucheye; Alebel, Animut; Soolingen, Dick van

doi:10.1371/journal.pone.0194675

Cited by 53 publications

(67 citation statements)

References 47 publications

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“…The treatment success rate of TB in this study was 64.6%, which is less than the 2017 WHO report, where the treatment success rate among 30 high TB burden countries varied from 71% to 94% [1] and the national report of overall treatment success rate in Ethiopia (83.7%) [19]. Moreover, the treatment success rate in the current study is still below the treatment success rate reported in Bahir Dar, Ethiopia, 80.8% [18], Tigray, Ethiopia, 89.2% [20] and China, 88% [12].…”

Section: Discussioncontrasting

confidence: 69%

Factors Associated with Mortality in Tuberculosis Patients at Debre Birhan Referral Hospital, Ethiopia: A Retrospective Study

Woldeamanuel¹,

Mingude²

2018

J Trop Dis

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Background: Tuberculosis (TB) is the major cause of mortality worldwide and deaths from tuberculosis continue to occur despite the availability of effective antimicrobial agents. Understanding the factors associated with death is important to decrease mortality from TB. Hence, the aim of this study was to assess the magnitude and factors leading to death among TB patients registered at Debre Birhan Referral Hospital, Debre Birhan, Ethiopia.Methods: This is a retrospective cross-sectional study. Data was obtained by assessing medical records of 262 tuberculosis patients registered at Debre demographic and clinical characteristics of the patients were collected from medical records using data extraction sheet. Chi-square analysis was used to determine the risk factors for TB mortality.Result: From a total of 262 registered TB patients included in the study, 249 were included in the analysis of which 41(16.5%) died during TB treatment. Of the patients with unsuccessful treatment outcome in this study, death was the most common advsserse TB treatment outcome. TB Mortality was significantly associated with the type of TB, HIV Co-infection, co-morbidity, sputum smear results and time to visit the hospital for diagnosis (p<0.05). Conclusion:The proportion of death among hospitalized TB patients was found to be high and several factors were associated with TB mortality. Hence, monitoring those factors is important to reduce the death rate in TB patients.

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Section: Discussioncontrasting

confidence: 69%

Factors Associated with Mortality in Tuberculosis Patients at Debre Birhan Referral Hospital, Ethiopia: A Retrospective Study

Woldeamanuel¹,

Mingude²

2018

J Trop Dis

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“…Higher rates of failure among patients previously treated for TB have been illustrated by others. [22][23][24][25] A cohort study on homeless patients with TB in Poland found that a significant number of homeless TB patients had been treated for TB in the past compared with non-homeless patients. 21 In that study, homeless patients also had lower rates of treatment success, although the study did not differentiate patients according to HIV status.…”

Section: Discussionmentioning

confidence: 99%

Homelessness and HIV: A Combination Predictive of Poor Tuberculosis Treatment Outcomes and in Need of Innovative Strategies to Improve Treatment Completion

Gómez

Paniagua-Saldarriaga

Richert

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Antioquia Department is the state with the highest burden of tuberculosis (TB) in Colombia. Our aim was to determine the risk factors associated with unsuccessful TB treatment in HIV-seropositive and homeless persons, compared with non-HIV-infected and non-homeless persons with TB. We conducted a retrospective cohort study using observational, routinely collected health data from all drug-susceptible TB cases in homeless and/or HIVseropositive individuals in Antioquia from 2014 to 2016. Unsuccessful TB treatment was defined as individuals having been lost to follow-up, having died, or treatment failure occurrence during the study period. Successful treatment was defined as cure of TB or treatment completion according to the WHO definitions. We identified 544 homeless persons with TB (432 HIV− and 112 HIV+), 835 HIV+ persons with TB and non-homeless, and 5,086 HIV−/non-homeless people with TB. Unsuccessful treatment rates were 19.3% in HIV−/non-homeless persons, 37.4% in non-homeless HIV+ patients, 61.5% in homeless HIV− patients, and 70.3% in homeless HIV+ patients; all rates fall below End TB strategy targets. More than 50% of homeless patients were lost to follow-up. Risk factors associated with unsuccessful treatment were HIV seropositivity, homelessness, male gender, age ³ 25 years, noncontributory-type health insurance, TB diagnosis made during hospitalization, and previous treatment for TB. These results highlight the challenge of treating TB in the homeless population. These findings should put an onus on TB programs, governments, clinicians, and others involved in the collaborative care of TB patients to pursue innovative strategies to improve treatment success in this population.

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“…Treatment success rate was low Amhara region which was 19.0%. The unsuccessful TB treatment outcome was found to be two times higher among HIV/TB co-infected cases (24). Studies showed the major determinants of HIV/TB co-infection were identified to be low CD4 counts, ART and WHO clinical stages, being divorced/widowed, not attending formal education, underweight, diabetic mellitus, smoking, TB in the family, alcohol consumption and chewing khat were the determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia (25)(26)(27).…”

Section: Introductionmentioning

confidence: 93%

Determinants for tuberculosis in HIV infected patients in Debre Birhan town, Amhara national regional state, Ethiopia: a case control study

Tewabe

zeleke

Mohammed

2019

Preprint

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Background: Tuberculosis (TB) is one of the most frequent opportunistic infections in people living with the Human Immunodeficiency Virus (HIV). It is a leading cause of morbidity and mortality in high HIV prevalent population. There are various factors contributing for the occurrence of TB/HIV co-infection that are not well studied in this area. The purpose of this study is to assess determinants of Tuberculosis infection among HIV positive patients attending ART clinics in governmental health facilities at Debre Birhan town North Shoa, Ethiopia. Methods: A case control study design was conducted from February 15, 2017 to April 30, 2017 in governmental health facilities at Debre Birhan town. A total of 276 individuals were to participated in this study (92 cases and 184 controls). Cases were adult patients with TB/HIV who were co-infection and controls were adult HIV patients without TB. A pre- tested interviewer administered structured questionnaire was used to collect data on Socio demographic variables, housing characteristics and personal behaviours. Host, clinical and immunological variables were taken from ART card and log books. Result: In this study participants who; earn low monthly income (AOR) 0.024; 95% CI 0.004 to 0.14), smoker (AOR 10.53; 95% CI 1.53 to 72.18), kerosene (AOR 2.49; 95% CI 1.22 to 5.07), alcohol (AOR=5.48; 95% CI 1.29 to 23.56), family history of TB (AOR=2.51; 1.03,6.15) were at high risk of tuberculosis. While patients with opportunistic infections (AOR=3.35; 95% CI 1.62 to 6.91), bronchial asthma (AOR=14.77; 95% CI 6.25 to 34.91), diabetes mellitus (AOR 10.62; 95% CI 2.77 to 40.50) and low CD4 level (AOR=6.03; 95% CI 2.27 to 16.18) were at high risk of TB. Conclusion: HIV patients with risk behaviours, opportunistic infections, diabetes, asthma, low CD4, kerosene user and poor were at risk of TB. To reduce the risk of TB health care providers and government should work to reduce risk behaviours, early screening and initiation of treatment for opportunistic infections, health education for chronic diseases, early staging and initiation of treatment for HIV, working with poor to improve their life were recommended. Key words: Tuberculosis Infection, HIV Patients, Debre Birhan Town, Ethiopia

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Tuberculosis treatment outcomes in Ethiopia from 2003 to 2016, and impact of HIV co-infection and prior drug exposure: A systematic review and meta-analysis

Cited by 53 publications

References 47 publications

Factors Associated with Mortality in Tuberculosis Patients at Debre Birhan Referral Hospital, Ethiopia: A Retrospective Study

Factors Associated with Mortality in Tuberculosis Patients at Debre Birhan Referral Hospital, Ethiopia: A Retrospective Study

Homelessness and HIV: A Combination Predictive of Poor Tuberculosis Treatment Outcomes and in Need of Innovative Strategies to Improve Treatment Completion

Determinants for tuberculosis in HIV infected patients in Debre Birhan town, Amhara national regional state, Ethiopia: a case control study

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