Tuberculosis series 2020

Silva, Denise Rossato; Mello, Fernanda Carvalho de Queiroz; Migliori, Giovanni Battista

doi:10.36416/1806-3756/e20200027

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…On the other hand, EVs can also function as antigen carriers to promote host response against bacterial infections [12,39]. Most of the available studies showing the role of MΦ-EVs in inducing anti-bacterial responses were carried out with Mycobacterium sp, a genus with a significant worldwide impact on public health [71,72]. However, other intracellular bacteria with the ability to modify EV cargo to regulate both innate and adaptive immune responses have also been a matter of investigations, most of them using THP-1 cells as a donor of EVs (Table 1).…”

Section: Macrophage-evs Can Contribute To Development Of Immune Responses Against Bacterial Infectionsmentioning

confidence: 99%

The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction

Arteaga-Blanco

Bou-Habib

2021

IJMS

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The nano-sized membrane enclosed extracellular vesicles (EVs) released by virtually all cell types play an essential role in intercellular communication via delivering bio-molecules, such as nucleic acids, proteins, lipids, and other molecules to recipient cells. By mediating an active and steady-state cell-to-cell communication, EVs contribute to regulating and preserving cellular homeostasis. On the other hand, EVs can also spread pathogen-derived molecules during infections, subverting the host immune responses during infections and thus worsening pathophysiological processes. In recent years, the biological functioning of EVs has become a widespread research field in basic and clinical branches of medical sciences due to their potential role in therapeutic applications for several diseases. This review aims to summarize the main recent findings regarding the implication of EVs shed by human macrophages (MΦ-EVs) and how they can modulate the host immune response to control or increase the damage caused by infectious agents. We will also present the methods used to describe MΦ-EVs, as well as the potential of these EVs as disease diagnostic tools for some human pathogens. We believe that an in-depth understanding of the host–pathogen interactions mediated by MΦ-EVs may trigger the development of innovative therapeutic strategies against infectious diseases.

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Section: Macrophage-evs Can Contribute To Development Of Immune Responses Against Bacterial Infectionsmentioning

confidence: 99%

The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction

Arteaga-Blanco

Bou-Habib

2021

IJMS

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“…Despite 9 decades of effective vaccination campaigns and 6 decades of anti-tuberculous medications, tuberculosis (TB) remains the most common cause of death from a single infectious agent worldwide. 1 Pulmonary tuberculosis (PTB) is an airborne communicable disease caused by Mycobacterium tuberculosis ( MTB ) bacilli, which are transmitted from person to person via inhalation of droplet nuclei classically generated by coughing. 2 Recently, it is estimated that about 25% of the world’s population have been infected with MTB .…”

Section: Introductionmentioning

confidence: 99%

The Footprint of Diabetes Mellitus on the Characteristics and Response to Anti-Tuberculous Therapy in Patients with Pulmonary Tuberculosis from Saudi Arabia

El-Kady¹,

S²

2021

IDR

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Background Right now, a tuberculosis (TB) and diabetes mellitus (DM) syndemic is re-emerging worldwide. Given the contradictory results of the impact of DM on the natural history of pulmonary TB (PTB), this study was undertaken to shed light on the precision of this hypothesis from a community with a substantial caseload of both diseases. Methods The present 5-year, retrospective, cohort study involved 487 (60.8% males, and 39.2% females) adult PTB patients (mean age 53.71 ± 15.78 years) selected from Dr. Soliman Fakeeh Hospital (DSFH), Jeddah, Kingdom of Saudi Arabia (KSA). The relevant patients’ clinical, radiological and microbiological data were extracted from the hospital medical and laboratory database. Results In our study, the cumulative prevalence of DM among PTB subjects was 27.1%. Both diabetic and non-diabetic groups were matched with regard to gender ( p = 0.46); however, diabetic patients were significantly older ( p = 0.0001). Patients with concomitant DM displayed higher frequency of the classic clinical presentations of PTB and were 1.8 times more likely to have cavitary lesions on imaging studies ( p = 0.012). Furthermore, diabetic patients showed higher initial sputum acid-fast bacillus (AFB) smear grade ( p = 0.0001) and were more prone to have delayed culture conversion as compared to their non-diabetic counterparts (77.55 ± 37.74 versus 54.95 ± 27.67 days, respectively; p = 0.0001) which points out to less favorable treatment outcome. Conclusion DM showed an impact on different aspects of PTB. Accordingly, integrated bi-directional screening programs for both diseases in the KSA need to be implemented to upgrade health-care services of patients with dual diagnosis.

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