Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Wong, Jason; Zhang, Han; Hsiung, Chao A.; Shiraishi, Kouya; Yu, Kai; Matsuo, Keitaro; Wong, Maria Pik; Hong, Yun-Chul; Wang, Jiucun; Seow, Wei Jie; Wang, Zhaoming; Song, Minsun; Kim, Heung Dong; Chang, I‐Shou; Chatterjee, Nilanjan; Hu, Wei; Wu, Chen; Mitsudomi, Tetsuya; Zheng, Wei; Kim, Jin Hee; Seow, Adeline; Caporaso, Neil E.; Shin, Min‐Ho; Chung, Lap Ping; An, Shejuan; Wang, Ping; Yang, Yang; Zheng, Hong; Yatabe, Yasushi; Zhang, Xuchao; Kim, Young Tae; Cai, Qiuyin; Yin, Zhihua; Kim, Young‐Chul; Bassig, Bryan A.; Chang, Jiang; Ho, James Chung Man; Ji, Bu‐Tian; Daigo, Yataro; Ito, Hidemi; Momozawa, Yukihide; Ashikawa, Kyota; Kamatani, Yoichiro; Honda, Takayuki; Hosgood, H. Dean; Sanada, Hiromi; Kunitoh, Hideo; Tsuta, Koji; Watanabe, Shun‐ichi; Kubo, Michiaki; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Tsuboi, Masahiro; Goto, Kōichi; Shi, Jianxin; Song, Lei; Hua, Xing; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Shimizu, Kimihiro; Tanaka, Kazumi; Wei, Fusheng; Matsuda, Fumihiko; Su, Jian; Kim, Yeul Hong; Oh, Il‐Seok; Song, Fengju; Su, Wu‐Chou; Chen, Yumin; Chang, Gee-Chen; Chen, Kuan‐Yu; Huang, Ming-Shyan; Chien, Li‐Hsin; Xiang, Yong‐Bing; Park, Jae Yong; Kweon, Sun‐Seog; Chen, Chien-Jen; Lee, Eunil; Blechter, Batel; Li, Haixin; Gao, Yu‐Tang; Qian, Biyun; Lu, Daru; Li, Jianjun; Jeon, Hyo-Sung; Hsiao, Chin‐Fu; Sung, Jae Sook; Tsai, Ying‐Huang; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Wang, Wenchang; Chung, Charles C.; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Berndt, Sonja I.; Wu, Wei; Pang, Herbert; Li, Yuqing; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, Chang Hyun; Zhu, Meng; Chen, Chung–Hsing; Yang, Tsung‐Ying; Xu, Jianing; Guan, Peng; Tan, Wen; Wang, Chih‐Liang; Hsin, Michael K.Y.; Sit, Ko‐Yung; Chen, Ying; Choi, Yi Young; Hung, Jen‐Yu; Kim, Jun Suk; Yoon, Ho Il; Lin, Chien‐Chung; Park, In Kyu; Xu, Ping; Wang, Yuzhuo; He, Qincheng; Perng, Reury-Perng; Chen, Chih-Yi; Vermeulen, Roel; Wu, Junjie; Lim, Wei‐Yen; Chen, Kun‐Chieh; Li, Yao-Jen; Li, Jihua; Chen, Hongyan; Yu, Chong‐Jen; Jin, Li; Jiang, Shih–Sheng; Liu, Jie; Yamaji, Taiki; Hicks, Belynda; Wyatt, Kathleen; Li, Shengchao A.; Dai, Juncheng; Ma, Hongxia; Jin, Guangfu; Song, Bao; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yong; Cui, Ping; Iwasaki, Motoki; Shimazu, Taichi; Tsugane, Shoichiro; Zhu, Junjie; Yang, Kang; Jiang, Gening; Fei, Ke; Wu, Guoping; Lin, Ho-Chun; Hui-ling, Chen; Fang, Yao-Huei; Tsai, Fang‐Yu; Hsieh, Wan-Shan; Yu, Jinming; Stevens, Victoria L.; Laird-Offringa, Ite A.; Marconett, Crystal N.; Rieswijk, Linda; Chao, Ann; Yang, Pan-Chyr; Shu, Xiao‐Ou; Wu, Tangchun; Wu, Yi Long; Lin, Dong; Chen, Kexin; Zhou, Baosen; Huang, Yunchao; Kohno, Takashi; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing

doi:10.1016/j.ygeno.2019.07.008

Cited by 18 publications

(10 citation statements)

References 60 publications

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“…From 2000 to 2016, tuberculosis deaths fell from 1.7 million to 1.3 million, yet an estimated 10.4 million new tuberculosis cases arose in 2016 [3]. Although a growing body of evidence has revealed the association between tuberculosis and cancer, [4][5][6][7][8][9][10] the global cancer burden attributable to tuberculosis has not been quantified, and therefore, the potential impact of tuberculosis elimination on cancer burden remains unclear. Quantification of global cancer burden attributable to tuberculosis can contribute to the global and national discussions on health system investments, especially in countries facing the double burden of tuberculosis infection and cancer.…”

Section: Introductionmentioning

confidence: 99%

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates

et al. 2020

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Background: Tuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown. Methods: We performed random-effects meta-analyses and meta-regressions of studies reporting the association between tuberculosis and cancer risks by searching PubMed, Web of Science, Embase, Cochrane library, and CINAHL from inception to 1 June 2019. Population attributable fractions (PAFs) of cancer incidence attributable to tuberculosis were calculated using relative risks from our meta-analyses and tuberculosis prevalence data from Global Health Data Exchange by age, sex, and country. The study has been registered with PROSPERO (CRD42016050691). Results: Fourty nine studies with 52,480 cancer cases met pre-specified inclusion criteria. Tuberculosis was associated with head and neck cancer (RR 2.64[95% CI 2.00-3.48]), hepatobiliary cancer (2.43[1.82-3.25]), Hodgkin's lymphoma (2.19[1.62-2.97]), lung cancer (1.69[1.46-1.95]), gastrointestinal cancer (1.62[1.26-2.08]), non-Hodgkin's lymphoma (1.61[1.34-1.94]), pancreatic cancer (1.58[1.28-1.96]), leukaemia (1.55[1.25-1.93]), kidney and bladder cancer (1.54[1.21-1.97]), and ovarian cancer (1.43[1.04-1.97]). We estimated that 2.33%(1.14-3.81) or 381, 035(187145-623,404) of global cancer incidences in 2015 were attributable to tuberculosis. The PAFs varied by Socio-demographic Index (SDI)-ranging from 1.28% (0.57-2.31%) in the high-SDI countries to 3.51% (1.84-5.42%) in the middle-SDI countries. Individually, China and India accounted for 47% of all tuberculosis-related cancer cases. Conclusions: Tuberculosis is associated with increased risk of cancer at ten sites. The burden of tuberculosis attributable cancer skewed towards lower resource countries. Research priorities are to better understand regional disparities and underlying mechanism linking tuberculosis and cancer development.

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Section: Introductionmentioning

confidence: 99%

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates

et al. 2020

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“…Does victimization worsen adolescent mental health (Singham et al 2017)? Does a tuberculosis infection increase the risk of lung adenocarcinoma (Wong et al 2020)? Or, as an example of particular interest at the time of writing, can inflammatory biomarkers such as IL-6 be targeted to decrease the risk of severe outcomes following SARS-CoV-2 infection (Bovijn et al 2020)?…”

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confidence: 99%

Causal Inference with Genetic Data: Past, Present, and Future

Pingault

Richmond

Smith

2021

Cold Spring Harb Perspect Med

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The set of methods discussed in this collection has emerged from the convergence of two scientific fields-genetics and causal inference. In this introduction, we discuss relevant aspects of each field and show how their convergence arises from the natural experiments that genetics offer. We present introductory concepts useful to readers unfamiliar with genetically informed methods for causal inference. We conclude that existing applications and foreseeable developments should ensure that we rapidly reap the rewards of this relatively new field, not only in terms of our understanding of human disease and development, but also in terms of tangible translational applications.

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“…Interestingly, results also indicate that adenocarcinoma is most frequently associated with a TB history, as reported by a systematic review 11 . Furthermore, Wong et al found an association between TB and lung adenocarcinoma (OR 1.31, 95% CI 1.03–1.66, p = 0.027) among never-smoking Asian women in a genome-wide association study using Mendelian randomization and pathway analysis 20 . Last, a recent meta-analysis concluded that pre-existing TB increases the risk of LC (RR 2.170 (1.833–2.569).…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological characteristics associated with the presence of the IS6110 Mycobacterim tuberculosis transposon in neoplastic cells from non-small cell lung cancer patients

Arrieta

Molina-Romero

Cornejo‐Granados

et al. 2022

Sci Rep

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Lung cancer (LC) and pulmonary tuberculosis (TB) are the deadliest neoplastic and bacterial infectious diseases worldwide, respectively. Clinicians and pathologists have long discussed the co-existence of LC and TB, and several epidemiologic studies have presented evidence indicating that TB could be associated with the development of LC, particularly adenocarcinoma. Nonetheless, this data remains controversial, and the mechanism which could underlie the association remains largely unexplored. Some bioinformatic studies have shown that human cancer biopsies have a very high frequency of bacterial DNA integration; since Mycobacterium Tuberculosis (MTb) is an intracellular pathogen, it could play an active role in the cellular transformation. Our group performed an exploratory study in a cohort of 88 LC patients treated at the Instituto Nacional de Cancelorogía (INCan) of Mexico City to evaluate the presence of MTb DNA in LC tissue specimens. For the first time, our results show the presence of the MTb IS6110 transposon in 40.9% (n = 36/88) of patients with lung adenocarcinomas. Additionally, through in-situ PCR we identified the presence of IS6110 in the nuclei of tumor cells. Furthermore, shotgun sequencing from two samples identified traces of MTb genomes present in tumor tissue, suggesting that similar Mtb strains could be infecting both patients.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Cited by 18 publications

References 60 publications

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates

Causal Inference with Genetic Data: Past, Present, and Future

Clinical and pathological characteristics associated with the presence of the IS6110 Mycobacterim tuberculosis transposon in neoplastic cells from non-small cell lung cancer patients

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