Tuberculosis in renal transplants in Rio de Janeiro

Matuck, Tereza Azevedo; Brasil, Patrícia; Alvarenga, Maria de Fátima; Morgado, Luciano Ferreira; Rels, M Drumond; Costa, Aloysio; Araújo, Marcelo Lodi; Rodrigues, Milene; Carvalho, Deise De Boni Monteiro de

doi:10.1016/j.transproceed.2004.03.093

Cited by 25 publications

(15 citation statements)

References 1 publication

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“…HCV infection, rather than HBV infection, has been reported as a risk factor for TB disease after renal transplantation. 12 – 14 Our study had similar results that HBV infection was not associated with active TB disease. However, the causal link between HCV infection and TB disease found in this study is biologically plausible.…”

Section: Discussionsupporting

confidence: 78%

Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Lin

Hsieh

et al. 2015

Medicine

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Section: Discussionsupporting

confidence: 78%

Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Lin

Hsieh

et al. 2015

Medicine

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“…All RCTs and most of the observational studies were conducted in high-endemic countries. [26][27][28][29][31][32][33][34] Consistent with our results, a study conducted in a low-to-intermediate endemic country, none of the 131 patients allocated to H developed TB. 35 A limitation of this study is that, as with other studies into the treatment of TB infection, participant selection may have been biased toward those willing to be screened.…”

Section: Discussionsupporting

confidence: 90%

“…A meta‐analysis 24 of six observational studies 25‐30 and four randomized controlled trials (RCTs) 31‐34 of preventive treatment with H in renal transplant recipients found that the rates of TB after transplant were between 0% and 16.7% among 510 patients who received preventive treatment. All RCTs and most of the observational studies were conducted in high‐endemic countries 26‐29,31‐34 . Consistent with our results, a study conducted in a low‐to‐intermediate endemic country, none of the 131 patients allocated to H developed TB 35 …”

Section: Discussionmentioning

confidence: 99%

“…In our cohort, only 1 of the 385 patients (0.3%) developed TB after transplant, which is lower than rates reported in highprevalence countries. 24 A meta-analysis 24 of six observational studies [25][26][27][28][29][30] and four randomized controlled trials (RCTs) [31][32][33][34] of preventive treatment with H in renal transplant recipients found that the rates of TB after transplant were between 0% and 16.7% among 510 patients who received preventive treatment. All RCTs and most of the observational studies were conducted in high-endemic countries.…”

Section: Discussionmentioning

confidence: 99%

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Tuberculosis prevention in patients undergoing kidney transplantation: A nurse‐led program for screening and treatment

Grijota-Camino

Montero

Luque

et al. 2021

Transplant Infectious Dis

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Background Systematic screening for, and treatment of, latent tuberculosis (TB) infection is recommended prior to kidney transplant. However, little is known about patient compliance with, or the safety profile of, preventive therapies used in clinical practice. Methods This was a retrospective observational study of patients who were eligible for kidney transplant and were evaluated for TB infection between January 2013 and June 2019 at the TB clinic of a tertiary care teaching hospital. All patient data were registered prospectively as part of our nurse‐led program before kidney transplant. We assessed completion rates, tolerance with therapy, development of TB, and associated workload. Results In total, 1568 patients were referred to our TB clinic for evaluation. Preventive therapy was given to 385 patients and completed by 340 (88.3%). Of these, 89 (23.1%) experienced some intolerance, with 27 requiring full discontinuation. After a median follow‐up of 45 months (1426 patient‐years), 206 (53.5%) of the treated patients received a kidney transplant; only one patient, who failed to complete treatment, developed post‐transplant TB (7.01 cases per 10 000 patient‐years; 95% confidence interval, 0.35‐34.59). Extra nurse or medical visits were required by 268 (69.6%) patients. Conclusion Despite the complexity and workload generated by patients with ESRD awaiting kidney transplant, preventive therapy for TB is effective in most cases. Our experience provides important evidence on the feasibility of preventive therapy for TB before kidney transplant when delivered as part of a comprehensive nurse‐led program.

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“…After screening titles and abstracts, 153 full-text articles were assessed. Finally, 13 studies (which included 6,547 patients) met the inclusion criteria ( John et al, 1994 ; Apaydin et al, 2000 ; Agarwal et al, 2004 ; Matuck et al, 2004 ; Vikrant et al, 2005 ; Naqvi et al, 2006 ; Naqvi et al, 2010 ; Kim et al, 2011 ; de Lemos et al, 2013 ; Kim et al, 2013 ; Kim et al, 2015 ; Kim et al, 2020 ; Dodani et al, 2021 ). The basic characteristics of these 13 studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Yuan

Chao

et al. 2023

Front. Pharmacol.

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Background: A systematic review and meta-analysis was performed to investigate the efficacy and safety of isoniazid (INH) prophylaxis to prevent tuberculosis (TB) infection in kidney transplant recipients (KTRs).Methods: Web of Science, SCOPUS, and PubMed were searched to identify relevant studies that compared the effects among patients who received INH prophylaxis after transplantation.Results: A total of 13 studies (involving 6,547 KTRs) were included in our analysis. We found that the risk of active TB infection (RR: 0.35, 95%CI 0.27–0.45, p < 0.01) for KTRs was lower in the INH treatment group than in those without prophylaxis. However, there was no significant difference between the two groups in mortality (RR: 0.93, 95%CI 0.67–1.28, p = 0.64), acute rejection (RR: 0.82, 95%CI 0.44–1.51, p = 0.52), and hepatotoxicity (RR: 1.25, 95%CI 0.94–1.65, p = 0.12).Conclusion: Isoniazid prophylaxis is a safe and effective for KTRs on reactivation of latent TB infection.

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Tuberculosis in renal transplants in Rio de Janeiro

Cited by 25 publications

References 1 publication

Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Tuberculosis prevention in patients undergoing kidney transplantation: A nurse‐led program for screening and treatment

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

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