Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Wu, Ping-Hsun; Lin, Yi Ting; Hsieh, Kun-Pin; Chuang, Hung‐Yi; Sheu, Chau‐Chyun

doi:10.1097/md.0000000000001328

Cited by 36 publications

(28 citation statements)

References 23 publications

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“…Findings from a previous study by Wu in Taiwan showed that the incidence of active TB is higher in HCV infections than the controls (134.1 vs. 89.1 per 100,000 personyear; incidence rate ratio=1.51; p=0.014). 55 Fist-line anti-TB medications (isoniazid= INH, rifampin=RIF, ethambutol=EMB, pyrazinamide=PZA) often produce drug-induced liver injury (DILI). The incidence of DILI was significantly higher in the HCV group (13/41 [31.7%], p<0.001) and the HBV + HCV group (3/4 [75.0%], p=0.002) than in the control group (25/251 [10.0%]).…”

Section: Discussionmentioning

confidence: 99%

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

Erawati¹,

Andriany²

2020

JMDH

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Purpose: To determine the prevalence and demographic risk factors for latent tuberculosis infection (LTBI) among healthcare workers in Semarang, Indonesia. Methods: A cross-sectional study involving 195 healthcare workers from 34 primary health centers was conducted from August to October 2019. The relationship between independent variables and dependent variables was analyzed using a multivariable logistic regression analysis. Results: The prevalence of LTBI among healthcare workers in this study was 23.6%. Comorbidities were the only risk factor for LTBI identified among other risk factors (OR=3.39, 95% CI: 0.99-11.62, p=0.04). Other demographic factors such as age (OR=0.93, 95% CI: 0.45-1.92, p=0.839), gender (OR=0.79, 95% CI: 0.23-2.72, p=0.708, smoking habits (OR=2.54, 95% CI: 0.52-12.38, p=0.247), and length of work (OR=1.43, 95% CI: 0.70-2.91, p=0.331) were not significant risk factors for LTBI. Conclusion: Healthcare workers suffering from comorbidity have a high risk for tuberculosis infection, and should not work in areas where they would be exposed to patients with tuberculosis. Healthcare workers need to apply occupational safety standards during contact with TB patients or specimens to minimize the disease transmission.

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Section: Discussionmentioning

confidence: 99%

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

Erawati¹,

Andriany²

2020

JMDH

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“…However, the causal link between HCV infection and TB risk remains unclear but a study has suggested that HCV infection is associated with a higher risk of developing active TB disease. 12 Injection drug use is a key factor in the transmission of blood borne pathogens. Behavioral epidemiological studies have shown that both injection-related risk factors of injecting drugs, type of drug injected, direct and indirect sharing of injection paraphernalia and sex-related risk factors (lack of condom use, multiple sexual partners, survival sex) have been associated with the spread of HIV, HBV and HCV.…”

Section: Introductionmentioning

confidence: 99%

Prevalence rates of HIV, HBsAg and HCV co-infections among tuberculosis patients in Sokoto Metropolis, Northwest Nigeria

Momodu¹,

Bala²,

Marafa³

2018

Sri Lankan J Infec Dis

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“…Epidemiologically, concomitant viral infections other than HIV are known to be associated with poor TB outcomes. In Taiwan Hepatitis C infection was associated with a higher risk of developing active TB disease , and in South Africa influenza/TB co‐infection was associated with increased mortality . A large TB vaccine trial in South Africa, which investigated correlates of TB disease risk or protection, found an association between CD8 T‐cell activation and HCMV response that was linked to an increased risk of TB disease and shorter time to diagnosis .…”

Section: Introductionmentioning

confidence: 99%

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

Stockdale

Nash

Nalwoga

et al. 2018

Tropical Med Int Health

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Objectives A growing evidence base implicates human cytomegalovirus ( HCMV ) as a risk factor for TB disease. We investigated total IgG and mycobacteria‐specific antibodies in a cross‐sectional study nested within a rural Ugandan General Population Cohort ( GPC ), in relation to HIV infection and the magnitude of HCMV IgG response. Methods Sera from 2189 individuals (including 27 sputum‐positive TB cases) were analysed for antibodies against mycobacteria (Ag85A, PPD , LAM , ESAT 6/ CFP 10) and HCMV , tetanus toxoid ( TT ) and total IgG. Results Anti‐mycobacterial antibodies increased with age until approximately 20 years, when they plateaued. Higher HCMV exposure (measured by IgG) was associated with lower levels of some anti‐mycobacterial antibodies, but no increase in total IgG. HIV infection was associated with a decrease in all anti‐mycobacterial antibodies measured and with an increase in total IgG. Conclusions The increase in anti‐mycobacterial antibodies with age suggests increasing exposure to non‐tuberculous mycobacteria ( NTM ), and to M.tb itself. HIV infection is associated with decreased levels of all mycobacterial antibodies studied here, and high levels of HCMV IgG are associated with decreased levels of some mycobacterial antibodies. These findings point towards the importance of humoral immune responses in HIV / TB co‐infection and highlight a possible role of HCMV as a risk factor for TB disease.

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Hepatitis C Virus Infection Is Associated With an Increased Risk of Active Tuberculosis Disease

Abstract: Supplemental Digital Content is available in the text

Cited by 36 publications

References 23 publications

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

Prevalence rates of HIV, HBsAg and HCV co-infections among tuberculosis patients in Sokoto Metropolis, Northwest Nigeria

HIV, HCMV and mycobacterial antibody levels: a cross‐sectional study in a rural Ugandan cohort

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