Tuberculosis en el área de Santiago de Compostela durante los años 1999, 2000, 2001 y 2002: Un estudio epidemiológico

Rodríguez, M. Salgueiro; Barcala, J. González; Sanz, C. Zamarrón; Pasin, Martins; Gabaldon, Josi R.; Garazo, M. B. Presedo; Alvarez, U; Molino, María Luisa Pérez del; López, J. Antúnez; Rivas, J. L. Durán; Suárez, J. L.

doi:10.4321/s0212-71992004000500003

Cited by 5 publications

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“…In hospitalized patients (general hospitalization), the prevalence of CNS-TB was 8.64% (95% CI 5.34–12.55; I 2 , 97.10%) based on 13 studies (14,409 patients and 448 cases) [ 15 , 62 , 64 , 73 , 74 , 77 – 81 , 92 , 95 , 98 ]. On the other hand, the prevalence of CNS-TB was 13.91% of all patients with meningitis (95% CI 10.40–17.81; I 2 , 99.70%; 33 studies, 171,619 patients, and 6460 cases) [ 9 , 11 – 16 , 20 – 22 , 26 , 30 , 31 , 34 – 38 , 41 , 44 , 47 – 52 , 54 , 70 , 79 , 83 , 86 , 88 ], and it represented the 4.55% of patients with TB (95% CI 2.63–6.97; I 2 , 98.81%; 11 studies, 202,265 patients, and 4043 cases) [ 7 , 11 , 17 , 63 , 68 , 69 , 71 , 72 , 90 , 92 , 98 ]. The forest plots for these analyses are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In patients with meningitis, TB meningitis represented the 14.63% (95% CI 10.95–18.73; I 2 , 99.71%) calculated from 32 studies including 169,538 total patients and 6322 cases [ 9 , 11 – 16 , 20 – 22 , 24 , 26 , 30 , 31 , 34 – 38 , 41 , 44 , 47 – 49 , 51 , 52 , 54 , 70 , 79 , 83 , 86 , 88 ]. Finally, in patients with TB, TB meningitis represented the 3.67% (95% CI 2.16–5.56; I 2 , 99.71%), from 10 studies including 201,223 total patients and 3875 cases [ 7 , 11 , 17 , 63 , 68 , 69 , 71 , 72 , 92 , 98 ]. The forest plots for these analyses are depicted by Fig.…”

Section: Resultsmentioning

confidence: 99%

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Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis

et al. 2022

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Background Tuberculosis (TB) is the second most common cause of death due to a single infectious agent worldwide after COVID-19. Up to 15% of the cases are extrapulmonary, and if it is located in the central nervous system (CNS-TB), it presents high morbidity and mortality. Still, the global epidemiology of CNS-TB remains unknown. Aim To estimate the global prevalence and incidence of CNS-TB based on the available literature. Methods We systematically searched in MEDLINE, Cochrane Central, Scopus, and LILACS databases (April 2020) and included observational studies evaluating the epidemiology of CNS-TB. Two independent researchers selected and assessed the quality of the studies and extracted relevant data. We performed random-effects model meta-analysis of proportions to estimate the pooled prevalence. The protocol of this study was registered in PROSPERO (CRD 42018103946). Results We included 53 studies from 28 countries, representing 12,621 patients with CNS-TB. The prevalence of CNS-TB was 2 per 100,000 inhabitants. According to the clinical setting, the prevalence of CNS-TB represented the 13.91% of all cases of meningitis and 4.55% of all cases of TB. The mortality was calculated by tuberculous meningitis due to the lack of data of other presentation, and it rose up to 42.12% in hospitalized patients. The burden of countries’ TB, Human Development Index (HDI), and the prevalence of HIV were the most important prevalence moderators, especially in patients with TB. No data on incidence were found. Conclusion The prevalence and mortality of CNS-TB remain high, and TB meningitis is the most frequent presentation. The highest prevalence was reported in developing countries, and its main moderators were the countries’ HDI and HIV infection. Our study was limited by high heterogeneity, risk of bias, and potential data under registration from developing countries. The integration of CNS-TB early detection and management into national TB programs and population-based studies from developing countries are needed for better global estimation and response. Supplementary Information The online version contains supplementary material available at 10.1007/s00415-022-11052-8.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis

et al. 2022

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“…En tan elevadas cifras de partida probablemente han jugado importante papel los altos índices de demora entre el inicio de síntomas y la consulta (25 días en Galicia frente a 22 en España) y las mayores tasas de tuberculosis bacilífera (25,4% frente al 13,8% nacional), si bien estas han conseguido reducirse a la mitad (desde 25,4% (1996) a 12,5% (2005)(10-12). Característica diferencial de Galicia, repetidamente comprobada, es el bajo porcentaje de tuberculosis asociada a la infección por VIH, justificativa del repunte de la enfermedad en otras Comunidades Autónomas (8,7% en Galicia frente al 17,7% del resto de España en 1996, aunque en años posteriores siempre fue <8%) (10,12,13). Además como se advierte en la gráfica 1, a partir de 1998 -año en que estaban ya generalizadas las terapias antirretrovíricas de alta efectividad-se reducen drásticamente los ingresos en enfermos con VIH y también aquellos con tuberculosis concomitante.…”

Section: Tuberculosis En Galicia: Algunas Batallas Ganadas Pero Aún No La Guerraunclassified

Tuberculosis: una “negra sombra” en la vida de Rosalía de Castro

Santiago¹

2008

Gal. Clin.

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La célebre escritora gallega Rosalía de Castro siempre temió enfermar de tuberculosis. En sus escritos se aparta de las consideraciones románticas acerca de la enfermedad como motor creativo y denunciará esta mitificación y la considerará como una pesada carga. Esta misma consideración desmitificadora estará presente en otros famosos escritores gallegos como Emilia Pardo Bazán, Wenceslao Fernández Flórez o Camilo José Cela. Al hilo de esta consideración se destacan los avances conseguidos en el último siglo en Galicia en el control de esta enfermedad, aunque alertando de su todavía importante repercusión sanitaria en esta comunidad y los posibles riesgos que puede comportar en años venideros.

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“…A pesar del descenso mundial del número de casos de tuberculosis (TBC) pulmonar, existe en la actualidad un incremento de manifestaciones de la TBC extrapulmonar (1,2), cuyo máximo exponente en términos de peor pronóstico o invalidez residual viene representado por la afectación neurológica (3). La afectación tuberculosa del SNC comprende la participación meníngea en la mayoría de las ocasiones, siendo escasas las complicaciones vasculares descritas en los pacientes adultos con ausencia de VIH (4).…”

Section: Introductionunclassified

Infarto de la arteria cerebral media como forma de presentación de la tuberculosis miliar

Etayo¹,

Azuara²,

Cía³

et al. 2008

An. Med. Interna (Madrid)

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Tuberculosis en el área de Santiago de Compostela durante los años 1999, 2000, 2001 y 2002: Un estudio epidemiológico

Abstract: In last four years the incidence of tuberculosis has decreased but remains high in males over 55 years old.

Cited by 5 publications

References 18 publications

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis

Tuberculosis: una “negra sombra” en la vida de Rosalía de Castro

Infarto de la arteria cerebral media como forma de presentación de la tuberculosis miliar

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