Tuberculosis en el adolescente; reto y oportunidad de evitar el contagio a la comunidad

Margarit, A. S.; Simó, Sergi; Rozas, Librada; Deyà‐Martínez, Àngela; Barrabeig, Irene; Gené, Amadeu; Fortuny, Clàudia; Noguera-Julián, Antoni

doi:10.1016/j.anpedi.2016.03.009

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…In line with other studies, [6][7][8] most of the patients attended the clinic due to the presence of symptoms despite having previous contact with the disease. The median lag time between symptom onset and diagnosis was 21 days, shorter than reported by other series; 8,9 however, the range is larger, reaching up to 1 year of evolution in some cases.…”

Section: Discussionsupporting

confidence: 89%

“…This becomes even more complex in adolescents given that their social contacts usually extend outside their family environment, which oftentimes results in a deficient contact investigation. 6 In our study population, the source of infection was unknown in more than half of the cases; however, a high percentage of close contact with tuberculosis (43%) was also observed. The age of the patients who knew the source of the infection was significantly lower than that of those who did not.…”

Section: Discussionmentioning

confidence: 67%

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Adolescent Tuberculosis: 6 Years of Experience in a Tertiary Care Pediatric Hospital in Buenos Aires, Argentina

Carril,

Neyro,

Pena Amaya

et al. 2023

Pediatric Infectious Disease Journal

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Introduction: Adolescence is a key risk period for tuberculosis disease and its adverse outcomes. This group commonly develops infectious forms of tuberculosis and has a wider range of social contacts outside the household. There are few specific data on the behavior of tuberculosis disease in this population. Methods: A total of 292 patients aged 10–19 years with tuberculosis between January 2016 and December 2021 were retrospectively analyzed in the Department of Phthisiology of the Children’s Hospital “Dr. Ricardo Gutiérrez” of Buenos Aires, Argentina. Results: The median patient age was 14 years (interquartile range 12–16). Most patients were previously healthy, and 55% were unaware of the source of the infection. However, 75% sought medical advice owing to the presence of symptoms, with hemoptysis and weight loss being most frequent in those older than 15 years. Lung imaging findings consistent with severe disease were significantly associated with an age of >15 years. Respiratory cultures were positive in 62% of the samples obtained. Half of the patients required hospitalization, while 45% showed extrapulmonary involvement. Evolution was as follows: 74% recovered from the illness, 13% were lost to follow-up, 11% were referred to a less complex facility, 1% experienced treatment failure, and 3 (1%) patients died. Pulmonary cavities and positive bacilloscopy were associated with the presence of pulmonary sequelae at the end of treatment. Conclusions: Tuberculosis in adolescents, particularly in those >15 years of age, may present characteristics similar to those of adults, with a higher frequency of severe pulmonary disease leading to pulmonary sequelae.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 67%

Adolescent Tuberculosis: 6 Years of Experience in a Tertiary Care Pediatric Hospital in Buenos Aires, Argentina

Carril,

Neyro,

Pena Amaya

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…In the world, there are reports that show the occurrence of TB unevenly between genders, with men and those of working age (16 to 65 years) being the most affected by the disease (Margarit et al, 2017). In our study, it was possible to observe these same characteristics.…”

Section: Discussionsupporting

confidence: 73%

Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Sales,

Pinto-Silva,

Bardález-Rivera

et al. 2023

Braz. J. Biol.

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This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p<0.0001). The results suggest a hepatotoxic effect of the drug, which recommends further studies with a larger number of samples in order to investigate the predictors of liver damage in patients with multidrug-resistant tuberculosis.

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Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)

et al. 2022

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IntroductionA considerable burden of the tuberculosis (TB) epidemic is found in adolescents. The reasons for increased susceptibility to TB infection and higher incidence of TB disease in adolescence, compared with the 5–10 years old age group, are incompletely understood. Despite the pressing clinical and public health need to better understand and address adolescent TB, research in this field remains limited.Methods and analysisTeen TB is an ongoing prospective observational cohort study that aims to better understand the biology, morbidity and social context of adolescent TB. The study plans to recruit 50 adolescents (10–19 years old) with newly diagnosed microbiologically confirmed pulmonary TB disease and 50 TB-exposed controls without evidence of TB disease in Cape Town, South Africa, which is highly endemic for TB. At baseline, cases and controls will undergo a detailed clinical evaluation, chest imaging, respiratory function assessments and blood collection for viral coinfections, inflammatory cytokines and pubertal hormone testing. At 2 weeks, 2 months and 12 months, TB disease cases will undergo further chest imaging and additional lung function testing to explore the patterns of respiratory abnormalities. At week 2, cases will complete a multicomponent quantitative questionnaire about psychological and social impacts on their experiences and longitudinal, in-depth qualitative data will be collected from a nested subsample of 20 cases and their families.Ethics and disseminationThe study protocol has received ethical approval from the Stellenbosch University Health Research Ethics Committee (N19/10/148). The study findings will be disseminated through peer-reviewed publications, academic conferences and formal presentations to health professionals. Results will also be made available to participants and caregivers.

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Tuberculosis en el adolescente; reto y oportunidad de evitar el contagio a la comunidad

Abstract: Adult-type pulmonary TB is common among adolescents, may be associated with underlying medical conditions, and is often diagnosed late, posing a significant transmission risk to the community.

Cited by 9 publications

References 11 publications

Adolescent Tuberculosis: 6 Years of Experience in a Tertiary Care Pediatric Hospital in Buenos Aires, Argentina

Adolescent Tuberculosis: 6 Years of Experience in a Tertiary Care Pediatric Hospital in Buenos Aires, Argentina

Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)

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