Tuberculin skin testing in inflammatory bowel disease patients from an endemic area of Brazil

Cardoso, Igor Machado; Almeida, Neogélia; Gotardo, Daniela Rosa Magalhães; Cardeal, Mauricio; Santana, Genoile Oliveira

doi:10.1016/j.bjid.2013.05.008

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…We found a higher positivity for CD, which may be related to the higher number of cases for this series. In addition, Cardoso et al found alterations in radiological findings and, perhaps, this may be justified by the socioeconomic difference of the population in question (29) . We focused on latent tuberculosis and its correlation in several aspects, such as disease classification, gender, age, work environment and others.…”

Section: Discussionmentioning

confidence: 98%

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Rate of Infection (Tuberculosis) in Brazilians Ibd Private Patients: Follow-Up 15 Years

CURY,

MICHELETTI

et al. 2024

Arq. Gastroenterol.

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Background: Latent tuberculosis (LTB) is a condition where the patient is infected with Mycobacterium tuberculosis but does not develop active TB. There’s a possibility of tuberculosis (TB) activation following the introduction of anti-TNFs. Objective: To assess the risk of biological therapy inducing LTB during inflammatory bowel diseases (IBD) treatment over 15 years in a high-risk area in Brazil. Methods: A retrospective study of an IBD patients’ database was carried out in a private reference clinic in Brazil. All patients underwent TST testing and chest X-ray prior to treatment, and once a year after starting it. Patients were classified according to the Montreal stratification and risk factors were considered for developing TB. Results: Among the analyzed factors, age and gender were risk factors for LTB. DC (B2 and P) and UC (E2) patients showed a higher number of LTB cases with statistical significance, what was also observed for adalimumab and infliximab users, compared to other medications, and time of exposure to them favored it significantly. Other factors such as enclosed working environment have been reported as risk. Conclusion: The risk of biological therapy causing LTB is real, so patients with IBD should be continually monitored. This study reveals that the longer the exposure to anti-TNFs, the greater the risk.

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Section: Discussionmentioning

confidence: 98%

“…Other studies have applied this surveillance test in Brazil to individuals who are candidates for biologic therapy (28,29) . Similar to our data, Brunelli et al used screening with TST to track patients in Brazil and prevent latent TB, showing the usefulness and applicability of this test in that population.…”

Section: Discussionmentioning

confidence: 99%

Rate of Infection (Tuberculosis) in Brazilians Ibd Private Patients: Follow-Up 15 Years

CURY,

MICHELETTI

et al. 2024

Arq. Gastroenterol.

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“…PCM Dermatology Online Journal || Case Report serology exams with false negative results may occur in limited lesions as well as in immunosuppressed patients [14]. Interestingly, CD could cause a decreased response and delayed hypersensitivity [15]. Additionally, AZA is a drug with side effects such as leukopenia and inhibition and apoptosis of T cells causing an anergic status [16].…”

Section: Case Discussionmentioning

confidence: 99%

Chronic paracoccidioidmycosis in a woman with Crohn Disease

Santos¹,

Andrade²,

Fernandes

et al. 2017

Dermatology Online Journal

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“…84 85 86 Using purines alone can also increase the risk of LTBI reactivation. 87 88 The combination of purines with glucocorticoids and/or TNF-α antagonists is more likely to cause LTBI reactivation than purines monotherapy.…”

Section: Ibd and M Tuberculosis Infectionmentioning

confidence: 99%

Evidence-based consensus on opportunistic infections in inflammatory bowel disease (republication)

2018

Intest Res

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Inflammatory bowel disease (IBD) patients are a high-risk population for opportunistic infections. The IBD group of the Chinese Society of Gastroenterology of the Chinese Medical Association organized an expert group to discuss and develop this consensus opinion. This consensus opinion referenced clinical study results from China and other countries to provide guidance for clinical practices. Eight major topics, including cytomegalovirus infection, Epstein-Barr virus infection, viral hepatitis, bacterial infection, Mycobacterium tuberculosis infection, fungal infection, parasitic infection, and vaccines were introduced in this article.

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Tuberculin skin testing in inflammatory bowel disease patients from an endemic area of Brazil

Abstract: Patients with IBD have TST results similar to the general Brazilian population. Within the IBD population, CD patients have a lower frequency of TST positivity than UC patients.

Cited by 7 publications

References 23 publications

Rate of Infection (Tuberculosis) in Brazilians Ibd Private Patients: Follow-Up 15 Years

Rate of Infection (Tuberculosis) in Brazilians Ibd Private Patients: Follow-Up 15 Years

Chronic paracoccidioidmycosis in a woman with Crohn Disease

Evidence-based consensus on opportunistic infections in inflammatory bowel disease (republication)

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