Chronic paracoccidioidmycosis in a woman with Crohn Disease

Oral Manifestations of Crohn’s Disease: A Systematic Review

“…Microscopically, we find chronic patchy and transmural inflammation, with an increase in plasma cells and lymphocytes, discontinuous irregularity of the crypts, but without rupture of the crypts, and the presence of non-caseating granulomas in the lamina propria. In oral biopsies of the reported cases, plasma cell and lymphocyte infiltrate and the presence of non-caseating granulomas of the lamina propria and submucosa were found in most of them [6,10,12,[14][15][16][17]19,20,22,23,25,28,30,34].…”

“…Regarding the location of the lesions mentioned, there is a predominance of lesions on the mucosa, especially on the lower lips and gums. Lesions are present in other less common locations, such as the soft palate, uvula, tongue, and pillars of the fauces [10][11][12][13][14][15][16][17][19][20][21][22][23][24][25][26][27][28]30,31].…”

“…There are several treatments for CD, but the most widespread is pharmacological. We highlight the use of aminosalicylates, corticosteroids, immunomodulators, and biological therapy [10][11][12][13][14][15][16][19][20][21][22][23][24][25][26][27][28]30,31]. Most patients with oral lesions were treated with systemic therapy; only three cases were reported where lesions were treated with topical corticosteroids.…”

“…Saede Atarbashi-Moghadam et al [21] stress the importance of using local treatment in the absence of systemic symptomatology but note that it has limited success [14,17,21,26]. In several articles mentioned, patients were treated with immunosuppressants and corticosteroids [10][11][12][13][14]16,19,20,[22][23][24][25][26][27][28]31]. The results were very good, as there was an improvement in oral and gastrointestinal lesions.…”

Intestinal Paracoccidioidomycosis: Case report and systematic review

“… 6 , 34 Concomitant IBD was observed in two patients diagnosed with PCM infection in the current review: a man with Ulcerative Colitis 23 and a woman with Chron's disease. 50 The patient was on immunosuppressive medications to treat the disease. According to the reported cases, the impaired immunity caused by the immunosuppressive therapy might have increased the risk for fungal infection.…”