Tu1270 An Overview of the Impact of Fecal Calprotectin Testing in the Management of Patients Within the Gastroenterology Outpatient Clinic in a General Hospital

Eccles, John; Neely, Alan; Lynch, Mark; Ferguson, Charles; Morrison, Graham

doi:10.1016/s0016-5085(14)62888-2

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“…In four pediatric participants with known IBD, one had a normal FCal level and was felt to be in remission but three had elevated levels that resulted in major changes in management. Similar to our study, the investigators concluded that FCal can serve as a marker for disease activity in known IBD and help in the clinical decision-making process (25). …”

Section: Discussionsupporting

confidence: 87%

“…FCal testing helped in assessment of disease activity and decision-making in 25 adults with known IBD; 21 had major changes in their treatment while 4 were felt to be in remission on biological therapy (25). In four pediatric participants with known IBD, one had a normal FCal level and was felt to be in remission but three had elevated levels that resulted in major changes in management.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Fecal Calprotectin Measurement on Decision-making in Children with Inflammatory Bowel Disease

et al. 2017

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BackgroundThe use of fecal calprotectin (FCal) as a marker of intestinal inflammation, in the management of inflammatory bowel disease (IBD) is increasing. The aim of this study was to examine the impact of FCal measurements on decision-making and clinical care of children with IBD.Materials and methodsIn a retrospective cohort study, FCal, clinical activity indices, and blood markers were measured in children with established diagnoses of IBD. Pearson correlation coefficient analysis was performed to examine association between FCal and other markers. Decisions based on FCal measurements were prospectively documented and participants were evaluated 3–6 months later.ResultsA total of 115 fecal samples were collected from 77 children with IBD [median age 14, interquartile range (IQR) 11–15.6 years, 42 females, 37 with Crohn’s disease]. FCal positively correlated with clinical activity indices (r = 0.481, P < 0.05) and erythrocyte sedimentation rate (r = 0.40, P < 0.05) and negatively correlated with hemoglobin (r = −0.40, P < 0.05). Sixty four out of 74 (86%) positive FCal measurements (≥250 μg/g of stools) resulted in treatment escalation with subsequent significant clinical improvement while in the FCal negative group, 34 out of 41 (83%) measurements resulted in no change in treatment and were associated with remission on follow-up.ConclusionBased on high FCal, the majority of children had treatment escalation that resulted in clinical improvement. FCal measurements were useful and reliable in decision-making and clinical care of children with IBD.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%