TT virus levels in the plasma of infected individuals with different hepatic and extrahepatic pathology

Abstract

TT virus (TTV) infection is extremely widespread in the general population. A sensitive real-time PCR assay was developed that quantitated accurately the most prevalent TTV genotypes in Italy. When used to test 217 individuals for TTV viraemia, the overall prevalence was 94%. Viraemia levels varied widely amongst individual subjects, with no major differences related to gender or age. The highest TTV titres were in haemophiliacs and in patients with non-A-E hepatitis, but they did not differ from the group with miscellaneous diseases. HIV- and HCV-infected subjects and patients with primary liver diseases had TTV loads similar to those of healthy individuals.

TT Virus Infection of Periodontal Tissues: A Controlled Clinical and Laboratory Pilot Study

“…Procedures for quantification of copy number and evaluation of intra-and interassay precision and reproducibility of the assay have been previously reported. 11,12 The lower limit of sensitivity of the assay was 1.0 × 10 3 copies per ml of saliva or per gram of tissue.…”

Transfusion‐transmitted virus is not present in factor IX concentrates commonly used to treat haemophilia B

“…Fourteen lots of Mononine Ò and three lots of BeneFix Ò were purchased from a commercial vendor. A plasma sample previously determined to contain TTV DNA was generously provided by Dr Bendenelli (University of Pisa, Italy) and used as a positive control [3].…”