TSH, Thyroid Hormone, and PTC—Response

Huang, Huang; Rusiecki, Jennifer; Udelsman, Robert; Zhang, Yawei

doi:10.1158/1055-9965.epi-17-0806

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Epidemiologic evidence suggests that T3 and T4 exhibit tumor-promoting effects for other hormonally related cancers, such as ovarian, prostate, pancreatic cancers [ 52 ]. Epidemiologic studies have also observed associations between TSH and risk of thyroid cancer; a recent nested case-control study documented sex-specific differences in this relationship and the potential for increased risk of papillary thyroid cancer among individuals with TSH hormones outside of the normal range on either the low or high end [ 53 , 54 ]. In studies of laboratory animals, TSH and thyroid hormones have also been related to tumor growth [ 52 ], and high TSH levels were linked to papillary thyroid cancer initiation in a mouse model [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

Deziel¹,

Yi²,

Stapleton

et al. 2018

BMC Cancer

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BackgroundGrowing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship between PFR exposure and thyroid cancer and whether individual or temporal factors predict PFR exposure.MethodsWe analyzed interview data and spot urine samples collected in 2010–2013 from 100 incident female, papillary thyroid cancer cases and 100 female controls of a Connecticut-based thyroid cancer case-control study. We measured urinary concentrations of six PFR metabolites with mass spectrometry. We estimated odds ratios (OR) and 95% confidence intervals (95% CI) for continuous and categories (low, medium, high) of concentrations of individual and summed metabolites, adjusting for potential confounders. We examined relationships between concentrations of PFR metabolites and individual characteristics (age, smoking status, alcohol consumption, body mass index [BMI], income, education) and temporal factors (season, year) using multiple linear regression analysis.ResultsNo PFRs were significantly associated with papillary thyroid cancer risk. Results remained null when stratified by microcarcinomas (tumor diameter ≤ 1 cm) and larger tumor sizes (> 1 cm). We observed higher urinary PFR concentrations with increasing BMI and in the summer season.ConclusionsUrinary PFR concentrations, measured at time of diagnosis, are not linked to increased risk of thyroid cancer. Investigations in a larger population or with repeated pre-diagnosis urinary biomarker measurements would provide additional insights into the relationship between PFR exposure and thyroid cancer risk.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4553-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

Deziel¹,

Yi²,

Stapleton

et al. 2018

BMC Cancer

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“…Moreover, higher TSH levels in patients with benign nodules have been associated with higher risks of differentiated thyroid cancer and advanced tumor stages [47]. Serum TSH levels in the abnormal range have also been associated with the risk of developing thyroid cancer [37,38]. Therefore, exposure to parabens may interfere with the homeostasis of thyroid hormones, stimulate thyroid cells to secrete and release large amounts of bioactive factors such as cell growth factors and vascular endothelial growth factors, which in turn lead to the development of benign nodules and thyroid cancer [29] such as observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Moeller et al found that, altered TH levels may increase the incidence of multiple tumors [27,35,36]. Abnormal TSH levels have also been related to increased risk of thyroid cancer from an US study [37,38].…”

Section: Introductionmentioning

confidence: 99%

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

Wu¹,

Zhu²,

Liu³

et al. 2021

Preprint

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Parabens are widely used as preservatives, which have been found to affect thyroid function in toxicological studies. However, population studies on whether they are associated with thyroid tumor remain unclear. This study aims to investigate the relationship between environmental paraben exposure and thyroid cancer and benign nodules. The detectable percentages of methyl paraben, ethyl paraben, and propyl paraben in the urinary samples of 425 study subjects were 99.06%, 95.29% and 92.00%, respectively. In the single pollutant model, we found statistically significant difference between certain parabens and thyroid cancer/ benign nodules. Further, we found the mixture effect of parabens on increased risk of thyroid cancer (OR = 0.24, 95% CI: 0.18, 0.31) and benign nodule (OR =1.33, 95% CI: 0.86, 1.80). The significant gender-associated effects were found in associations with certain parabens and thyroid cancer and benign nodules (Both P for interactions < 0.05). Overall, our results showed that individual exposure of paraben mixtures may be associated with the risk of thyroid cancer and benign nodules, and there were gender differences.

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Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China

Xiong

Xie

et al. 2022

Environ Sci Pollut Res

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TSH, Thyroid Hormone, and PTC—Response

Cited by 3 publications

References 4 publications

A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China

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