Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China

Wu, Nan-Xin; Xiong, Feng; Xie, Jin-Ying; Li, Xiaojie; Zeng, Qiang; Sun, Jiachen; Chen, Da; Pan, Yang

doi:10.1007/s11356-022-20741-w

Cited by 7 publications

(3 citation statements)

References 68 publications

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“…High concentrations of the same three aforementioned parabens (MP, EP and PP), both individually and jointly, were associated with a higher risk of thyroid cancer in Chinese adults (Wu et al 2022). In women from the United States, post-diagnostic levels of MP, PP and total parabens were positively associated to the risk of developing breast cancer (Parada et al 2019); nevertheless, a case-control study nested within a multi-ethnic cohort of postmenopausal women from the United States reported an inverse association for pre-diagnostic levels of total parabens (Wu et al 2021).…”

Section: Discussion and Conclusion Resultsmentioning

confidence: 99%

Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort

Fernández-Martínez,

Rodríguez-Barranco,

Zamora-Ros

et al. 2023

Environ Sci Pollut Res

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The etiology of prostate cancer is not fully elucidated. Among environmental risk factors, endocrine-disrupting chemicals (EDCs) deserve special mention, as they alter metabolic pathways involved in hormone-dependent cancers. Epidemiological evidence assessing the carcinogenicity of EDCs is scarce. The aim of this study was to analyze the relationship between exposure to parabens and benzophenones and prostate cancer risk.We conducted a case-cohort study nested within the EPIC-Spain prospective multi-center cohort. Study population comprised 1,838 sub-cohort participants and 467 non-sub-cohort prostate cancer cases. Serum concentrations of four parabens and two benzophenones were assessed at recruitment. Covariates included age, physical activity, tobacco smoking, alcohol consumption, body mass index, educational level and diabetes. Borgan II weighted Cox proportional hazard models strati ed by study center were applied.Median follow-up time was 18.6 years (range = 1.0-21.7 years). Most sub-cohort participants reached primary education at most (65.5%), were overweight (57.7%) and had a low level of physical activity (51.3%). Detection percentages varied widely, being lowest for butyl-paraben (11.3%) and highest for methylparaben (80.7%), which also showed the highest geometric mean (0.95 ng/ml). Cases showed signi cantly higher concentrations of methyl-paraben (p = 0.041) and propyl-paraben (p < 0.001). In the multivariable analysis, methyl-paraben -log-transformed (HR = 1.07; 95%CI = 1.01-1.12) and categorized into tertiles (HR = 1.60 for T3; 95%CI = 1.16-2.20) -, butyl-paraben -linear (HR = 1.19; 95%CI = 1.14-1.23) and log-transformed (HR = 1.17; 95%CI = 1.01-1.35)and total parabens -log-transformed (HR = 1.09; 95%CI = 1.02-1.17) and categorized into tertiles (HR = 1.62 for T3; 95%CI = 1.10-2.40) -were associated with an increased prostate cancer risk.In this study, higher concentrations of methyl-, butyl-, and total parabens were positively associated with prostate cancer risk. Further research is warranted to con rm these ndings.

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Section: Discussion and Conclusion Resultsmentioning

confidence: 99%

Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort

Fernández-Martínez,

Rodríguez-Barranco,

Zamora-Ros

et al. 2023

Environ Sci Pollut Res

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“…That community-based analysis found that those living in an area known to have experienced PFAS contamination of drinking water showed greater risk ratios of thyroid cancer relative to those living in unexposed control areas [ 37 ]. Additionally, one previous biomonitoring study found that increased urinary levels of the parabens MPB, EPB, and PPB were positively associated with odds of thyroid cancer [ 38 ]. Importantly, both previous studies assessed thyroid cancer outcomes among both men and women combined, while our analysis was only able to assess previous thyroid cancer diagnoses in women due to low case numbers among men.…”

Section: Discussionmentioning

confidence: 99%

Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses

Cathey,

Nguyen,

Colacino

et al. 2023

J Expo Sci Environ Epidemiol

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Background Some hormonally active cancers have low survival rates, but a large proportion of their incidence remains unexplained. Endocrine disrupting chemicals may affect hormone pathways in the pathology of these cancers. Objective To evaluate cross-sectional associations between per- and polyfluoroalkyl substances (PFAS), phenols, and parabens and self-reported previous cancer diagnoses in the National Health and Nutrition Examination Survey (NHANES). Methods We extracted concentrations of 7 PFAS and 12 phenols/parabens and self-reported diagnoses of melanoma and cancers of the thyroid, breast, ovary, uterus, and prostate in men and women (≥20 years). Associations between previous cancer diagnoses and an interquartile range increase in exposure biomarkers were evaluated using logistic regression models adjusted for key covariates. We conceptualized race as social construct proxy of structural social factors and examined associations in non-Hispanic Black, Mexican American, and other Hispanic participants separately compared to White participants. Results Previous melanoma in women was associated with higher PFDE (OR:2.07, 95% CI: 1.25, 3.43), PFNA (OR:1.72, 95% CI: 1.09, 2.73), PFUA (OR:1.76, 95% CI: 1.07, 2.89), BP3 (OR: 1.81, 95% CI: 1.10, 2.96), DCP25 (OR: 2.41, 95% CI: 1.22, 4.76), and DCP24 (OR: 1.85, 95% CI: 1.05, 3.26). Previous ovarian cancer was associated with higher DCP25 (OR: 2.80, 95% CI: 1.08, 7.27), BPA (OR: 1.93, 95% CI: 1.11, 3.35) and BP3 (OR: 1.76, 95% CI: 1.00, 3.09). Previous uterine cancer was associated with increased PFNA (OR: 1.55, 95% CI: 1.03, 2.34), while higher ethyl paraben was inversely associated (OR: 0.31, 95% CI: 0.12, 0.85). Various PFAS were associated with previous ovarian and uterine cancers in White women, while MPAH or BPF was associated with previous breast cancer among non-White women. Impact Statement Biomarkers across all exposure categories (phenols, parabens, and per- and poly- fluoroalkyl substances) were cross-sectionally associated with increased odds of previous melanoma diagnoses in women, and increased odds of previous ovarian cancer was associated with several phenols and parabens. Some associations differed by racial group, which is particularly impactful given the established racial disparities in distributions of exposure to these chemicals. This is the first epidemiological study to investigate exposure to phenols in relation to previous cancer diagnoses, and the first NHANES study to explore racial/ethnic disparities in associations between environmental phenol, paraben, and PFAS exposures and historical cancer diagnosis.

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“…In mammals, PBs have been shown to increase thyroid volume in rats 21 . Population studies suggest that individual exposure to PBs may be associated with the risk of benign thyroid nodules and cancer 22 . PBs also interfere with thyroid hormone metabolism in humans 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%

High-dose exposure to butylparaben impairs thyroid ultrastructure and function in rats

Jiang,

Li,

Zeng

et al. 2024

Sci Rep

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Parabens (PBs) are a class of preservatives commonly used in cosmetics and pharmaceuticals. Studies have shown that these compounds may act as endocrine disruptors, affecting thyroxine levels in humans. PBs with longer chain substituents, such as butylparaben (BuP), are less prone to complete biotransformation and are therefore more likely to accumulate in the body. In this study, the effect of high-dose exposure to BuP on thyroid microstructure, ultrastructure, and function was investigated in rats. 50 mg/kg bw per day of BuP was injected subcutaneously into the neck of rats for 4 weeks. Rat thyroid weight, microstructure, and ultrastructure were determined, and the levels of thyroid sodium/iodide symporter (NIS), serum thyroid hormones, and thyroid autoantibodies were measured. The human thyroid cell line was used to study the mechanism of BuP on thyroid epithelial cells. The weight of the thyroid gland of BuP-exposed rats was increased, the structure of the thyroid follicles was irregular and damaged, the mitochondria and rough endoplasmic reticulum were swollen and damaged, and the microvilli at the tip of the epithelium were reduced and disappeared. Serum total T3, total T4, free T3, and free T4 were decreased in BuP-exposed rats, and TSH, peroxidase antibody, and thyroglobulin antibody were increased. In vitro, BuP decreased the level of NIS in thyroid epithelial cells, inhibited proliferation and viability, and induced apoptosis in a dose-dependent manner. This study demonstrated that high-dose exposure to BuP induced structural, ultrastructural, and functional impairment to the thyroid gland of rats, which may be one of the factors leading to hypothyroidism.

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Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China

Cited by 7 publications

References 68 publications

Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort

Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort

Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses

High-dose exposure to butylparaben impairs thyroid ultrastructure and function in rats

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