Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Ranieri, Girolamo; Ammendola, Michele; Patruno, Rosa; Celano, Giuseppe; Zito, Francesco Alfredo; Montemurro, Severino; Rella, Addolorata; Lecce, Vincenzo Di; Gadaleta, Cosmo Damiano; Sarro, G. B. De; Ribatti, Doménico

doi:10.3892/ijo_00000319

Cited by 84 publications

(62 citation statements)

References 40 publications

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“…Tryptase-positive mast cells increase in number and vascularization increases in a linear fashion in solid tumors, such as human malignant melanoma , endometrial carcinoma (Benítez-Bribiesca et al 2001, Ribatti et al 2005, breast cancer (Ribatti et al, 2007a;Ranieri et al, 2009), uterine leiomyomas (Ribatti et al, 2007b), colorectal cancer (Gulubova and Vlaykova, 2009).…”

Section: Resultsmentioning

confidence: 99%

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

et al. 2011

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Human mast cells (MCs) are divided in two types depending on the expression of tryptase and chymase in their granules. Literature data indicate that both tryptase and chymase are angiogenic, but there is currently no evidence of their direct angiogenic activity in vivo. In this study, we have investigated the capacity of tryptase and chymase to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay to study angiogenesis and anti-angiogenesis. The results showed that both tryptase and chymase stimulate angiogenesis and that the response is similar to that obtained with vascular endothelial growth factor (VEGF), a well-known angiogenic cytokine, and confirm the angiogenic activity of these two proteases stored in MC granules.

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Section: Resultsmentioning

confidence: 99%

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

et al. 2011

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“…Angiogenesis is a complex process involved in the growth, invasion and metastasis of several human tumors [1,2,3]. Mast cells (MCs) intervene in this process via the release of classical proangiogenic factors, such as vascular endothelial growth factor (VEGF), thymidine phosphorylase and fibroblast growth factor-2, and nonclassical proangiogenic factors, such as tryptase and chymase, which are stored in their secretory granules [4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically

et al. 2013

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Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T_3-4N_2a-bM₀ (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T₃N_2-3M₀ (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.

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“…The correlation between the MCs number and vascular density was observed in breast, gastric, colorectal, endometrial and oral cancers, melanomas and non-small cell lung carcinomas [6]. Tryptase-positive MCs count correlated with MVD in sentinel lymph nodes containing breast cancer micrometastases as well as in early breast cancer [37]. The number of microvessels was shown to be correlated with tryptase-positive MCs and rose with the progression of endometrial carcinoma [38].…”

Section: Resultsmentioning

confidence: 90%

Microvascular density and mast cells in benign and malignant pheochromocytomas

Białas¹,

Dyduch²,

Szpor³

et al. 2012

pjp

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Pheochromocytomas, uncommon adrenal tumors, have an uncertain behavior. Recently, PASS criteria were proposed for differentiating between benign and malignant cases. These are not perfect, however. The aim of the study was to investigate angiogenesis and mast cell density in context of the clinical behavior and morphologic characteristics of pheochromocytomas. Mean intratumoral chymase positive cell count was 14.50 for malignant, 15.73 for benign cases; mean subcapsular chymase positive cell count was 12.50 for malignant, 11.27 for benign cases. Mean intratumoral tryptase positive cell count was 17.50 for malignant and 17.91 for benign cases; mean subcapsular tryptase positive cell count was 15.25 for malignant and 15.73 for benign cases. Mean intratumoral CD31 positive vessel count was 46.98 for malignant and 51.02 for benign cases; mean subcapsular CD31 positive vessel count was 44.86 for malignant and 39.81 for benign cases. Mean intratumoral CD105 positive vessel count was 37.84 for malignant and 35.95 for benign cases; mean subcapsular CD105 positive vessel count was 26.36 for malignant and 22.03 for benign cases. The differences between benign and malignant cases were not significant. All the vascular counts were correlated with mast cells counts. PASS index was inversely correlated with mast cell counts.

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Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Cited by 84 publications

References 40 publications

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay

Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically

Microvascular density and mast cells in benign and malignant pheochromocytomas

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