2003
DOI: 10.1016/s0165-5728(03)00090-0
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Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: possible relevance to multiple sclerosis

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Cited by 59 publications
(48 citation statements)
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“…In addition, tryptase can stimulate human endothelial cells for increased production of MCP-1 and IL-8 [24, 25, 91], chemokines which can attract neutrophils and many other cells of the immune system. Furthermore, tryptase activates peripheral blood mononuclear cells for TNF-, IL-6 and IL-1 production [109], human neutrophils for IL-8 secretion [197], and human T cells for IL-6 release [101]. Activation of these cells is very likely mediated via activation of the proteinase-activated receptor-2 (PAR-2) by tryptase.…”
Section: Mast Cell Serine Proteinases In Psoriasismentioning
confidence: 99%
“…In addition, tryptase can stimulate human endothelial cells for increased production of MCP-1 and IL-8 [24, 25, 91], chemokines which can attract neutrophils and many other cells of the immune system. Furthermore, tryptase activates peripheral blood mononuclear cells for TNF-, IL-6 and IL-1 production [109], human neutrophils for IL-8 secretion [197], and human T cells for IL-6 release [101]. Activation of these cells is very likely mediated via activation of the proteinase-activated receptor-2 (PAR-2) by tryptase.…”
Section: Mast Cell Serine Proteinases In Psoriasismentioning
confidence: 99%
“…Mast cell tryptase is a major secretory protein of human mast cells, which is elevated in the CSF of patients with multiple sclerosis (MS) [3]. It can stimulate peripheral mononuclear cells to secrete TNF-alpha and IL-6 [4], as well as activate PAR-2 to induce widespread inflammation [5].…”
Section: Introductionmentioning
confidence: 99%
“…Tryptase stimulates endothelial cells to synthesize and release IL-1β and IL-8 that induce leukocyte infiltration (van Haelst et al, 2001;Compton et al, 1998). Tryptase can also activate peripheral blood mononuclear cells to produce and secrete IL-6 and TNF-α (Malamud et al, 2003), so as to affect the occurrence and development of inflammation in vascular system. The proteinase-activated receptor 2 (PAR-2) on multiplicate cells can be activated by tryptase to react on its physiological roles.…”
Section: Discussionmentioning
confidence: 99%