Trypanosoma cruzi isolated from a triatomine found in one of the biggest metropolitan areas of Latin America

Ribeiro, A. R.; Oliveira, Rosane Correa de; Ceretti, Walter; Lima, Luciana; Almeida, Larissa Aguiar de; Nascimento, Juliana Damieli; Teixeira, Marta Maria Geraldes; Rosa, João Aristeu da

doi:10.1590/0037-8682-0366-2015

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…Silva and Nussenzweig isolated the Y strain ( T. cruzi ) from an acute human case reported in the city of Marília, São Paulo State, Brazil. Because of its high virulence (type II) and resistance to the current drugs, most of the animals died in the experiments during the acute phase …”

Section: Discussionmentioning

confidence: 99%

“…Because of its high virulence (type II) and resistance to the current drugs, most of the animals died in the experiments during the acute phase. [56][57][58][59][60][61] According to the literature, the pre-manifestation period occurs before the acute phase, and it lasts until the 7th day postinfection (dpi). The parasitaemia peaks after inoculation of the Y strain (T. cruzi) and occurs in 21-28 dpi.…”

Section: Discussionmentioning

confidence: 99%

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Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study

Scarim

Andrade

Rosa

et al. 2018

Int J Experimental Path

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Summary Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short‐ and long‐term treatment. In the present study, we induced the indeterminate form of Chagas disease in mice with a Y strain of Trypanosoma cruzi and analysed the histopathological data about the effects of NFOH and BZN on different tissues, including the heart, skeletal muscle, liver, kidney, colon, spleen and brain. After infection, BALB/c mice were treated with NFOH (150 mg/kg) and BZN (60 mg/kg) for 60 days and then submitted to immunosuppression using dexamethasone (5 mg/kg) for 14 days. Two trained analysts, as part of a blind evaluation, examined the results using serial sections of 3 mm diameter in two different moments. The results showed reactivation of the disease only in the infected nontreated group (POS). After treatment, amastigote nests were found in the heart, colon, liver and skeletal muscle in the POS group and in the heart and liver of the BZN group. Interestingly, amastigote nests were not found in the NFOH and NEG groups. The histopathological analysis showed fewer tissue lesions and parasite infiltrates in the NFOH group when compared with the BZN and POS groups. We have not observed any increase in the levels of hepatocellular injury biomarkers (AST/ALT) in the NFOH group. These in vivo studies show the potential for NFOH as an effective and safe compound useful as an anti‐T. cruzi agent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study

Scarim

Andrade

Rosa

et al. 2018

Int J Experimental Path

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“…Among the triatomines submitted to parasitological examination, one P. megistus specimen, a male captured in the district of Jabaquara, was positive for T. cruzi , according to Ribeiro et al . 7 .…”

Section: Resultsmentioning

confidence: 99%

“…The city of Sao Paulo is located in what was formerly the Atlantic rainforest, an environment with high biodiversity considered one of the 23 “biodiversity hotspots” worldwide 10 . Despite the intense expansion of the city in the last five decades, there have been sporadic occurrences of triatomine bugs on the outskirts of Sao Paulo, some in unusual situations 7 , 11 .…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that populations of this species remain in forest fragments, where they can perpetuate the T. cruzi sylvatic transmission cycle within the boundaries of the municipality of Sao Paulo. In 2016, Ribeiro et al 7 reported positivity for T. cruzi in a P. megistus bug captured in an urban area of the city. In a study of epidemiological surveillance in Sao Paulo between 2010 and 2012, Silva et al .…”

Section: Discussionmentioning

confidence: 99%

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Occurrences of triatomines (Hemiptera: Reduviidae) and first reports of Panstrongylus geniculatus in urban environments in the city of Sao Paulo, Brazil

Ceretti-Júnior

Vendrami

Matos-Junior³

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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This note reports on occurrences of triatomine species in the city of Sao Paulo, Brazil, registered between 1988 and 2017. Records of triatomines captured in Sao Paulo are based on specimens received spontaneously from Health Surveillance Centers, Health Centers and Zoonosis Control Centers in the city as well as from citizens. Species were identified morphologically at the Public Health Entomology Laboratory, Faculty of Public Health, University of Sao Paulo, where the triatomines, which are vectors of Chagas disease, were tested for Trypanosoma cruzi infection. The first reported occurrence of triatomine bugs in urban Sao Paulo was in 1988. The specimen, which was captured in Jardim Sao Luiz district, was from the genus Panstrongylus and was registered as Panstrongylus sp. but was not sexed. Since this first recorded occurrence, the following species have been found in the city: Panstrongylus geniculatus (2 occurrences), P. megistus (15 occurrences), Triatoma infestans (1 occurrence) and T. sordida (3 occurrences). In this paper, the importance of reporting occurrences of triatomine bugs in the city of Sao Paulo, one of the largest metropolis in the world, is discussed with an emphasis on P. megistus. The occurrences discussed here indicate the importance of entomological surveillance for these vectors even in urban centers although the possibility of vector transmission of Chagas disease in these centers is very low.

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Molecular characterization of Trypanosoma cruzi DTUs of the triatomine species in a Chagas disease endemic area

et al. 2021

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Trypanosoma cruzi isolated from a triatomine found in one of the biggest metropolitan areas of Latin America

Cited by 13 publications

References 26 publications

Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study

Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study

Occurrences of triatomines (Hemiptera: Reduviidae) and first reports of Panstrongylus geniculatus in urban environments in the city of Sao Paulo, Brazil

Molecular characterization of Trypanosoma cruzi DTUs of the triatomine species in a Chagas disease endemic area

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