Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi

Morello, Antonio; Lipchenca, I.; Cassels, Bruce K.; Speisky, Hernán; Aldunate, J.; Repetto, Yolanda

doi:10.1016/1367-8280(94)90063-9

Cited by 35 publications

(25 citation statements)

References 15 publications

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“…The activity of a series of alkaloids against epimastigotes was associated to the inhibition of cell respiration, and the most active compound was apomorphine (Morello et al 1994). Using epimastigotes of Nif-resistant, the activity of β-carboline alkaloids was also associated with respiratory chain (Rivas et al 1999).…”

Section: Drugs Derived From Natural Sourcesmentioning

confidence: 98%

A Critical Review on Chagas Disease Chemotherapy

Coura¹,

Castro

2002

Mem. Inst. Oswaldo Cruz

826

442

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Section: Drugs Derived From Natural Sourcesmentioning

confidence: 98%

A Critical Review on Chagas Disease Chemotherapy

Coura¹,

Castro

2002

Mem. Inst. Oswaldo Cruz

826

442

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“…Although a broad spectrum of bioactivities and SAR of the aporphine and benzylisoquinoline alkaloids have been reported, their antinociceptive effects have been rarely investigated. As well, some of the biological effects of these alkaloids, such as anti-trypanosomal and the inhibition on lipoxygenase activity were found closely correlated with their antioxidant activity (Morello et al, 1994;Mišik et al, 1995).…”

Section: Introductionmentioning

confidence: 96%

Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen

Zhao

Wang

2006

Journal of Ethnopharmacology

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“…In general, boldine is well known for its potent antioxidant activity. However, recent studies have found that this compound also possesses antitrypanosomal,15 hepatoprotective,16 and anti-inflammatory properties 17. Although a preliminary cytotoxic effect was reported in bladder carcinoma and glioma cancer cells,18,19 the anticancer mechanism of boldine has yet to be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Paydar¹,

Kamalıdehghan²,

Wong³

et al. 2014

DDDT

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To date, plants have been the major source of anticancer drugs. Boldine is a natural alkaloid commonly found in the leaves and bark of Peumus boldus. In this study, we found that boldine potently inhibited the viability of the human invasive breast cancer cell lines, MDA-MB-231 (48-hour IC50 46.5±3.1 μg/mL) and MDA-MB-468 (48-hour IC50 50.8±2.7 μg/mL). Boldine had a cytotoxic effect and induced apoptosis in breast cancer cells as indicated by a higher amount of lactate dehydrogenase released, membrane permeability, and DNA fragmentation. In addition, we demonstrated that boldine induced cell cycle arrest at G2/M phase. The anticancer mechanism is associated with disruption of the mitochondrial membrane potential and release of cytochrome c in MDA-MB-231. Boldine selectively induced activation of caspase-9 and caspase-3/7, but not caspase-8. We also found that boldine could inhibit nuclear factor kappa B activation, a key molecule in tumor progression and metastasis. In addition, protein array and Western blotting analysis showed that treatment with boldine resulted in downregulation of Bcl-2 and heat shock protein 70 and upregulation of Bax in the MDA-MB-231 cell line. An acute toxicity study in rats revealed that boldine at a dose of 100 mg/kg body weight was well tolerated. Moreover, intraperitoneal injection of boldine (50 or 100 mg/kg) significantly reduced tumor size in an animal model of breast cancer. Our results suggest that boldine is a potentially useful agent for the treatment of breast cancer.

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Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi

Cited by 35 publications

References 15 publications

A Critical Review on Chagas Disease Chemotherapy

A Critical Review on Chagas Disease Chemotherapy

Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen

Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

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