Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model

Baldissera, Matheus D.; Silva, Aleksandro S. Da; Oliveira, Camila Belmonte; Santos, Roberto C.V.; Vaucher, Rodrigo de Almeida; Raffin, Renata P.; Gomes, Patrícia; Dambros, Maria G.C.; Miletti, Luiz Cláudio; Boligon, Alexandra Augusti; Athayde, Margareth Linde; Monteiro, Sílvia González

doi:10.1016/j.exppara.2014.03.007

Cited by 56 publications

(29 citation statements)

References 35 publications

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“…It has been used successfully in just a handful of cases, among others, to combat Demodex sp. in humans (Kleina Schmidt et al 2010 ; Tighe et al 2013 ; Cheng et al 2015 ), Bovicola ovis in sheep (James and Callander 2012 ) and in vitro and in vivo against Trypanosoma evansi in mice (Baldissera et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection

2017

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Eye diseases caused by amoebae from the genus Acanthamoeba are usually chronic and severe, and their treatment is prolonged and not very effective. The difficulties associated with therapy have led to attempts at finding alternative treatment methods. Particularly popular is searching for cures among drugs made of plants. However, no substances with total efficacy in treating Acanthamoeba keratitis have been identified.Results of our semi in vivo studies of tea tree oil simulating eyeball infection demonstrated 100% effectiveness in the case of both trophozoites and cysts of amoebae from the genus Acanthamoeba. The action of tea tree oil indicates that this is the first substance with a potential ability to quickly and effectively remove the amoebae from the eye. Tea tree oil has the ability to penetrate tissues, which allows it to destroy amoebae in both the shallow and deep layers of the cornea. The present research into the use of tea tree oil in the therapy of Acanthamoeba infection is the first study of this type in parasitology. It offers tremendous potential for effective treatment of Acanthamoeba keratitis and other diseases caused by these protozoa.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection

2017

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“…in trypanosomosis control has the ability to normalize blood parameters (hematocrit, total hemoglobin and erythrocytes) in infected animals (Ngotho et al, 2011), but in some cases the treatment with this drug may have a hepatotoxic and nephrotoxic (Spinosa et al, 1999) effect, verified in biochemical analyses. In consequence of this, researchers have tested natural products such as essential oils and propolis extract to T. evansi (Baldissera et al, 2013(Baldissera et al, , 2014bDe Dorneles et al, 2013;Gressler et al, 2012), as well as, recently, in vitro trypanocidal activity of the extracts of Achyrocline satureioides on T. evansi (Baldissera et al, 2014a). Nanomolecule drugs present some advantages over conventional drugs, such as slow gradual controlled release, increased bioavailability and reduced toxicity (Roco, 2003).…”

Section: Introductionmentioning

confidence: 98%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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“…Increased attention has been given to botanical pesticides due to their natural origin, the wide range of potential material resources, as well as many secondary plant metabolites that are degradable, harmless and non‐resistant (Kedia, Prakash, Mishra, Singh, & Dubey, ; Valmas & Ebert, ). The essential oil is derived from a native Australian plant, Melaleuca alternifolia (Baldissera, Da Silva, Oliveira, Santos, et al., ). This species is widely cultivated to use as fragrances, and flavours in the perfume and food industries, as well as in aromatherapy (Ponce, del Valle, & Roura, ).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, insecticidal and biochemical effects of Melaleuca alternifolia essential oil on the Helicoverpa armigera

Liao

Xiao

Zhou

et al. 2017

J Applied Entomology

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Pesticide resistance has developed as a result of long-term and extensive use of chemical pesticides. Essential oils from aromatic plants may provide a new and safe alternative to conventional insecticides. In this study, the insecticidal activities of the essential oil of Melaleuca alternifolia and their chemical constituents against Helicoverpa armigera Hubner were investigated, and the underlying mechanisms were studied. The essential oil showed distinct antifeedant (AFC 50 = 8.93 mg/ml) and good contact (LD 50 = 50.28 μg/larva) activities against H. armigera at 24 hr. Ten chemical components were identified using a gas chromatograph/mass spectrometer, and mainly included terpinen-4-ol (40.09%), γ-terpinene (21.85%), α-terpinene (11.34%), α-terpineol

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Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model

Cited by 56 publications

References 35 publications

Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection

Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Chemical composition, insecticidal and biochemical effects of Melaleuca alternifolia essential oil on the Helicoverpa armigera

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