Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo, Guilherme M. do; Baldissera, Matheus D.; Vaucher, Rodrigo de Almeida; Rech, Virgínia Cielo; Oliveira, Camila Belmonte; Sagrillo, Michele Rorato; Boligon, Alexandra Augusti; Athayde, Margareth Linde; Alves, Marta Palma; França, Raqueli Teresinha; Lopes, Sonia T.A.; Schwertz, Claiton I.; Mendes, Ricardo E.; Monteiro, Sílvia González; Silva, Aleksandro S. Da

doi:10.1016/j.exppara.2014.12.005

Cited by 27 publications

(21 citation statements)

References 56 publications

(55 reference statements)

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“…Outro estudo com intuito de avaliar a atividade tripanocida in vitro de extratos de marcela (Achyrocline satureioides) contra Trypanosoma evansi, registrou a morte de tripomastigotas, em concentrações mais altas (500 e 1.000 µg / ml), no período pós 1 hora, evidenciando resultados trypanocidas 23 .…”

Section: Fitoterápicosunclassified

Plantas medicinais nativas do bioma pampa com potencial anti-trypanosoma cruzi / Native Medicinal plants from the pampa biome with potential anti-trypanosoma cruzi

Grala¹,

Sacramento²,

Leon³

et al. 2021

BJDV

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RESUMOEste artigo teve como objetivo realizar uma revisão de literatura sobre as plantas medicinais mais utilizadas pela população no RS, contempladas na REPLAME/RS, com potencial para o tratamento da doença de Chagas. Foi realizada uma revisão de literatura, com os seguintes descritores: "planta medicinais", "Trypanosoma cruzi" e "doença de chagas", selecionados, nos sites PubMed, SciELO, LILACS e no Portal de Periódicos CAPES. 50 artigos foram lidos na íntegra, dos quais cinco foram explanados no texto. Das plantas estudadas com potencial anti-Tripanosoma no RS, destacam-se as espécies: Achyrocline satureioides popularmente conhecida como "marcela"; Baccharis trimera identificada como "carqueja"; ambas pertencentes à família Asteraceae e Eugenia uniflora L., intitulada "pitangueira", e contemplada na família Myrtaceae. O estado do RS apresenta plantas promissoras para desenvolvimento de pesquisas com resultados em tecnologias e terapêuticas apropriadas anti o gênero Trypanosoma, com ênfase para a espécie T. cruzi.

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Section: Fitoterápicosunclassified

Plantas medicinais nativas do bioma pampa com potencial anti-trypanosoma cruzi / Native Medicinal plants from the pampa biome with potential anti-trypanosoma cruzi

Grala¹,

Sacramento²,

Leon³

et al. 2021

BJDV

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“…According to Carmo et al (2015) [ 61 ] and Baldissera et al (2014) [ 62 ], the essential oil from the species Achyrocline satureioides (Lam.) DC.…”

Section: Essential Oils With Trypanocidal Activitymentioning

confidence: 99%

“…In this type of cell death, there are also alterations to the mitochondria, ATP depletion, generation of reactive oxygen species, and cytoplasm vacuolization [ 70 ]. The essential oils of Melaleuca alternifolia [ 61 ], Xylopia frutescens [ 20 ], Xylopia laevigata [ 20 ], Cymbopogon citratus [ 44 , 61 ], Cymbopogon giganteus [ 44 ], Cymbopogon nardus [ 44 ], and Cymbopogon schoenantus [ 44 ] presented this type of action.…”

Section: Proposed Mechanisms Of Action For the Trypanocidal Activimentioning

confidence: 99%

“…During apoptosis, there are alterations such as cytoplasmic blebbing, cell volume reduction, loss of mitochondrial membrane potential, condensation of nuclear chromatin, and DNA fragmentation [ 71 ]. Such characteristics were observed from the essential oils of Cinnamodendron dinisii [ 14 ], Siparuna guianensis [ 14 ], Cinnamomum verum [ 19 ], Lippia dulcis [ 30 ], Achyrocline satureioides [ 61 , 62 ], Lippia sidoides [ 13 ], Lippia origanoides [ 13 , 30 , 65 ], Chenopodium ambrosioides [ 13 ], Justicia pectorales [ 13 ], Lippia citriodora [ 30 ], Lippia pedunculosa [ 31 ] and Lippia alba [ 30 ]. However, due to the large number of components and potential synergistic and/or antagonistic interactions between them, it is likely that in addition to membranes, essential oils can also act against other cellular targets ( Figure 2 ).…”

Section: Proposed Mechanisms Of Action For the Trypanocidal Activimentioning

confidence: 99%

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Trypanocidal Essential Oils: A Review

et al. 2020

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Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.

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“…Nanoencapsulated natural remedies, including tea tree oil, curcumin, and Achyrocline satureioides oil, have all shown greater efficacy against different trypanosome species than non-carrier-based formulations [92-94]. Nanoencapsulated compounds showed greater trypanostatic or trypanocidal effect against T. evansi , with a reduction in side effects and effective dose.…”

Section: Nanocapsules and Polymeric Micellesmentioning

confidence: 99%

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

Volpedo

Costa

Ryan

et al. 2019

J. Venom. Anim. Toxins incl. Trop. Dis

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Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp. , Trypanosoma cruzi , and Trypanosoma brucei respectively. These diseases have their own unique challenges which are associated with the development of effective prevention and treatment methods. Collectively, these parasitic diseases cause more deaths worldwide than all other NTDs combined. Moreover, many current therapies for these diseases are limited in their efficacy, possessing harmful or potentially fatal side effects at therapeutic doses. It is therefore imperative that new treatment strategies for these parasitic diseases are developed. Nanoparticulate drug delivery systems have emerged as a promising area of research in the therapy and prevention of NTDs. These delivery systems provide novel mechanisms for targeted drug delivery within the host, maximizing therapeutic effects while minimizing systemic side effects. Currently approved drugs may also be repackaged using these delivery systems, allowing for their potential use in NTDs of protozoan origin. Current research on these novel delivery systems has provided insight into possible indications, with evidence demonstrating their improved ability to specifically target pathogens, penetrate barriers within the host, and reduce toxicity with lower dose regimens. In this review, we will examine current research on these delivery systems, focusing on applications in the treatment of leishmaniasis, Chagas disease, and African trypanosomiasis. Nanoparticulate systems present a unique therapeutic alternative through the repositioning of existing medications and directed drug delivery.

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Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Cited by 27 publications

References 56 publications

Plantas medicinais nativas do bioma pampa com potencial anti-trypanosoma cruzi / Native Medicinal plants from the pampa biome with potential anti-trypanosoma cruzi

Plantas medicinais nativas do bioma pampa com potencial anti-trypanosoma cruzi / Native Medicinal plants from the pampa biome with potential anti-trypanosoma cruzi

Trypanocidal Essential Oils: A Review

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

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