While technological innovation is a core element of efforts to increase public welfare, innovators are rarely trained to take the societal dimensions of innovation into account in a systematic manner. Responsible innovation has emerged within policy discourses worldwide to address this challenge. Implementing responsible innovation in daily practices, however, requires addressing both the multidisciplinary and the culturally situated nature of innovation processes. Effectiveness of Socio-Technical Integration Research (STIR) has been tested, but primarily only in developed countries, raising questions about how well it works in innovation and cultural settings differing from Western cultures. Therefore, this study analyzes the possibities of institutionalizing responsible innovation in an Eastern European country, namely in Hungary. For this investigation, we conducted STIR-pilots in two Hungarian natural science research groups. The fi ndings show that though the original STIR method can be adapted to support responsible innovation practices in Hungary, the differences in the innovation environment and culture (such as grant-driven innovation; lack of trust; less knowledge on responsible innovation; lack of law on the societical impacts of research and innovaton) require methodological modifi cations in order to improve STIR's effectiveness.