TRPV1 is involved in the antinociceptive effects of resveratrol in paclitaxel-induced neuropathic pain

Zhang, Yaodong; Huang, Fengyu; Xu, Yinfeng; Xiang, Wei; Xie, Chaofan

doi:10.1080/26895293.2020.1861111

Cited by 10 publications

(6 citation statements)

References 43 publications

(45 reference statements)

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“…These results show that resveratrol not only has an analgesic effect but also showed an effect that was able to improve the condition of mechanical allodynia due to oxaliplatin induction. These results are supported by other studies which state that resveratrol is the potential to reduce allodynia and has an effect for several days after the last administration 9,26 . However, in this study, it was shown that the higher the dose of resveratrol didn"t show a consistent increase in the withdrawal threshold in each test so that increasing the dose did not affect the increase in the withdrawal threshold.…”

Section: Result: Effect Of Andrographolide and Resveratrol On Periphe...supporting

confidence: 86%

Effect of Andrographolide and Resveratrol on OX1R and Prepro-orexin mRNA expression in CIPN-induced hypothalamus of mice with oxaliplatin

Ardianto

Judoko

Aprilia

et al. 2022

RJPT

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Chemotherapy-induced peripheral neuropathy (CIPN) is a one of side effect in cancer patients that receive antineoplastic agent, like oxaliplatin. Orexinergic system in the hypothalamus is the one of system that modulate nociceptive and neuropathy. Because there is flavonoids such as resveratrol and andrographolide that may prevent chemotherapy induced peripheral neuropathy, this study analyzed effects of andrographolide and resveratrol treatment on PPOrx and OX1R mRNA expression in hypothalamic oxaliplatin-induced mice. Materials and Methods This study was conducted for 22 days in mice. Mice injected with oxaliplatin followed by andrographolide or resveratrol. Chemotherapy induced peripheral neuropathic pain was assessed based on withdrawal threshold, mRNA PPOrx expression, and mRNA OX1R expression. Results The results showed that intraperitoneal injection of 100mg/kg resveratrol and 20mg/kg andrographolide increased the withdrawal threshold after oxaliplatin induction. Resveratrol administration also increased the relative expression of PPOrx mRNA significantly, but not the OX1R mRNA relative expression. On the other hand, administration of andrographolide did not cause a change in the expression of PPOrx and OX1R in the hypothalamus. Conclusions Intraperitoneal injection of andrographolide and resveratrol reduces the mechanical allodynia response in oxaliplatin-induced mice significantly. The mechanism of andrographolide increases the withdrawal threshold does not via the orexinergic system, but the mechanism of resveratrol via the orexinergic system.

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Section: Result: Effect Of Andrographolide and Resveratrol On Periphe...supporting

confidence: 86%

Effect of Andrographolide and Resveratrol on OX1R and Prepro-orexin mRNA expression in CIPN-induced hypothalamus of mice with oxaliplatin

Ardianto

Judoko

Aprilia

et al. 2022

RJPT

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“…Several phytochemicals that interact with TRP channels were shown to be potential treatments for COVID-19 [ [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] , [129] , [130] , [131] , [132] , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] ]. However, the implication of TRP channel in their mechanism of action had not been investigated yet.…”

Section: Resultsmentioning

confidence: 99%

“…Resveratrol is a polyphenol present in peanuts, berries, and red grapes 122]. This polyphenol is a ligand for TRPV1, TRPA1, TRPM2, and TRPC5 channels [ [123] , [124] , [125] , [126] ]. In Vero E6 cells, resveratrol and its structurally related compound (pterostilbene) inhibited SARS-CoV-2 infection effectively by interfering with the post-entry steps of viral replication cycle [ 127 ].…”

Section: Resultsmentioning

confidence: 99%

TRP channels in COVID-19 disease: Potential targets for prevention and treatment

Jaffal

Abbas

2021

Chemico-Biological Interactions

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Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and trans-membrane protease serine 2 [TMPRSS2]. Many patients complain from pneumonia, cough, fever, and gastrointestinal (GI) problems. Notably, different TRP channels are expressed in various tissues infected by SARS-CoV-2. TRP channels are cation channels that show a common architecture with high permeability to calcium [Ca 2+ ] in most sub-families. Literature review shed the light on the possible role of TRP channels in COVID-19 disease. TRP channels may take part in inflammation, pain, fever, anosmia, ageusia, respiratory, cardiovascular, GI and neurological complications related to COVID-19. Also, TRP channels could be the targets for many active compounds that showed effectiveness against SARS-CoV-2. Desensitization or blocking of TRP channels by antibodies, aptamers, small molecules or venoms can be an option for COVID-19 prevention and future treatment. This review provides insights into the involvement of TRP channels in different symptoms and mechanisms of COVID-19, potential treatments targeting these channels and highlights missing gaps in literature.

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“…Lastly, some other natural compounds, that are well-known ligands for TRPV-1, may inhibit SARS-CoV-2 as well as lessen some symptoms of COVID-19. Recognized examples are represented by quercetin ( 130 ), resveratrol ( 131 ), spermidine/spermine ( 132 ), naringenin ( 133 ), and baicalin. In a prospective, randomized, controlled, and open-label study, a daily dose of 1,000 mg of quercetin was given for 30 days to 152 outpatients affected by COVID-19 to study its adjuvant role in treating the initial symptoms and in preventing the severe effects of the disease.…”

Section: Therapy/treatmentmentioning

confidence: 99%

Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

et al. 2021

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The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected. The discovery that S protein includes two ankyrin binding motifs (S-ARBMs) and that the transient receptor potential vanilloid subtype 1 (TRPV-1) cation channels contain these ankyrin repeat domains (TRPs-ARDs) suggest that TRPV-1, the most studied member of the TRPV channel family, can play a role in binding SARS-CoV-2. This hypothesis is strengthened by studies showing that other respiratory viruses bind the TRPV-1 on sensory nerves and epithelial cells in the airways. Furthermore, the pathophysiology in COVID-19 patients is similar to the effects generated by TRPV-1 stimulation. Lastly, treatment with agonists that down-regulate or inactivate TRPV-1 can have a beneficial action on impaired lung functions and clearance of infection. In this review, we explore the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, with the aim of looking at novel strategies to control infection and mitigate symptoms, and trying to translate this knowledge into new preventive and therapeutic interventions.

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TRPV1 is involved in the antinociceptive effects of resveratrol in paclitaxel-induced neuropathic pain

Cited by 10 publications

References 43 publications

Effect of Andrographolide and Resveratrol on OX1R and Prepro-orexin mRNA expression in CIPN-induced hypothalamus of mice with oxaliplatin

Effect of Andrographolide and Resveratrol on OX1R and Prepro-orexin mRNA expression in CIPN-induced hypothalamus of mice with oxaliplatin

TRP channels in COVID-19 disease: Potential targets for prevention and treatment

Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

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