TRPs in Olfaction

Zufall, Frank

doi:10.1007/978-3-319-05161-1_8

Cited by 13 publications

(9 citation statements)

References 92 publications

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“…However, in other mammals, TRPC2 forms a functional channel in distinct tissues, such as the vomeronasal organ (VNO), testis, spleen and liver [55,56]. The importance of TRPC2 in the vomeronasal organ has obtained much interest in regard to pheromone detection, see reviews [57,58]. TRPC2 has been shown to interact with Homer 1, calmodulin, G q/11 , IP3R, and receptor transporting protein 1 (RTP1) [59][60][61].…”

Section: Trpc2mentioning

confidence: 99%

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Asghar

Törnquist

2020

IJMS

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Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.

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Section: Trpc2mentioning

confidence: 99%

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Asghar

Törnquist

2020

IJMS

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“…TRP canonical ion channels (TRPC) are Ca2+‐permeable cation channels that are activated in response to receptor‐mediated PIP2 hydrolysis (Ong et al, ). They are involved in a variety of sensory functions (Hardie, ; Zanini and Göpfert, ; Zufall, ) including menchanosensation (Gottlieb et al, ; Patel et al, ). In particular, TRPC6 is a candidate for mechanosensing which is widely distributed in mammalian tissues (Dietrich and Gudermann, ) including DRG neurons; consistently deletion of TRPC6 causes deficits in light touch (Alessandri‐Haber et al, ; Quick et al, ).…”

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confidence: 99%

Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4

Alonso-González

Cabo

José

et al. 2017

The Anatomical Record

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Ion channels are at the basis of the sensory processes including mechanosensing. Some members of the transient receptor potential (TRP) ion channel superfamily have been proposed as mechanosensors, but their putative role in mechanotransduction is controversial. Among them there are TRP canonical 6 (TRPC6) and TRP vanilloid 4 (TRPV4) ion channels, which are known to cooperate in mechanical hyperalgesia. Here, we investigated the occurrence, distribution, and possible colocalization of TRPC6 and TRPV4 in human digital Meissner sensory corpuscles using immunohistochemistry and double immunofluorescence (associate with markers for specific corpuscular constituents). TRPC6 immunoreactivity was restricted to the axon of Meissner corpuscles, whereas TRPV4 was detected in the axon but also in the lamellar cells. Moreover, axonal colocalization of TRPV4 and TRPC6 was found in the digital Meissner corpuscles. Present results demonstrate for the first time the occurrence and colocalization of two ion channels candidates to mechanosensors in human cutaneous mechanoreceptors. The functional significance of these ion channels in that place remains to be clarified, but should be related to different properties of mechanosensitivity. Anat Rec, 300:1022-1031, 2017. © 2016 Wiley Periodicals, Inc.

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“…Of particular interest are the preliminary data presented here about the occurrence of TRPC2 in the olfactory epithelium of adult zebrafish. This ion channel is related to the detection of pheromones and sexual behavior in mammals [90,91] and since zebrafish lack of a true vomeronasal organ age, sex, seasonal changes in TRPC2 must be analyzed in depth. Regarding the taste, and differently to mammals [35], the involvement of TRP ion channels has been poorly studied, while no great differences seem to exist with respect to ASICs (see [80]).…”

Section: Discussionmentioning

confidence: 99%

Transient-Receptor Potential (TRP) and Acid-Sensing Ion Channels (ASICs) in the Sensory Organs of Adult Zebrafish

Germanà¹,

Muriel²,

Cobo³

et al. 2018

Recent Advances in Zebrafish Researches

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Sensory information from the aquatic environment is required for life and survival of zebrafish. Changes in the environment are detected by specialized sensory cells that convert different types of stimuli into electric energy, thus originating an organ-specific transduction. Ion channels are at the basis of each sensory modality and are responsible or are required for detecting thermal, chemical, or mechanical stimuli but also for more complex sensory processes as hearing, olfaction, taste, or vision. The capacity of the sensory cells to preferentially detect a specific stimulus is the result of a characteristic combination of different ion channels. This chapter summarizes the current knowledge about the occurrence and localization of ion channels in sensory organs of zebrafish belonging to the superfamilies of transient-receptor potential and acid-sensing ion channels that are involved in different qualities of sensibility superfamilies in the sensory organs of zebrafish. This animal model is currently used to study some human pathologies in which ion channels are involved. Furthermore, zebrafish is regarded as an ideal model to study in vivo the transient-receptor potential ion channels.

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TRPs in Olfaction

Cited by 13 publications

References 92 publications

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4

Transient-Receptor Potential (TRP) and Acid-Sensing Ion Channels (ASICs) in the Sensory Organs of Adult Zebrafish

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