Trpm7

Abstract

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain and an enzymatically active kinase domain. TRPM7 has been found in every mammalian tissue investigated to date. The two-in-one protein structure, the ubiquitous expression profile, and the protein’s unique biophysical characteristics that enable divalent ion transport involve TRPM7 in a plethora of (patho)physiological processes. With its prominent role in cellular and systemic magnesium homeostasis, TRPM7 emerges as a key player in embryonic development, global ischemia, cardiovascular disease, and cancer.

TRPM7 is a molecular substrate of ATP-evoked P2X7-like currents in tumor cells

“…This was unrelated to P2 receptor activation but most likely brought about by the release of these channels from a block by extracellular DICs, which are efficiently complexed by ATP when added at low millimolar concentrations that are typically required for P2X7 activation. As expected, the ubiquitously expressed TRPM7 (Fleig and Chubanov, 2014) was also present in the investigated tumor cell lines HEK293 and rat C6 glioma. The described mechanism should be considered when ascribing ATP-evoked cell responses to P2X7.…”

“…Paracrine effects of ATP on cancer growth may thus be mediated in principle by TRPM7 (Fleig and Chubanov, 2014) and P2X7 (Di Virgilio, 2012), which both have been shown to potentially promote tumor cell proliferation (Tani et al, 2007;Adinolfi et al, 2012) and invasiveness (Clark et al, 2006;Jelassi et al, 2011). With respect to gliomas, the P2X7 antagonist BBG has been shown to suppress tumor growth after the injection of rat C6 cells into the brain (Ryu et al, 2011).…”

Electrophysiological properties of NG2 + cells: Matching physiological studies with gene expression profiles

“…According to the RNA-Seq transcriptome database, the most highly-expressed TRP channel subunit in NG2 + cells is TRPM7, a nonspecific cation-permeable channel that contains an ion pore fused to a serine-threonine kinase domain (Fleig and Chubanov, 2014) (see Table 6). This channel is widely expressed and is likely important for the importation and homeostasis of trace metal ions (Monteilh-Zoller et al, 2003).…”

“…This channel is widely expressed and is likely important for the importation and homeostasis of trace metal ions (Monteilh-Zoller et al, 2003). It has also been demonstrated to play a role in proliferation, migration, differentiation, and death of a variety of cell types (Fleig and Chubanov, 2014). However, the role of TRPM7 has not been specifically examined in NG2 + cells.…”

Trpm7 Protein Contributes to Intercellular Junction Formation in Mouse Urothelium

“…Trpm7 (transient receptor potential melastatin 7) and its closest homolog Trpm6 are unique members of the TRP channel family because they have a kinase domain within the same polypeptide (5). Trpm7 is a ubiquitously expressed non-selective cation channel that has been reported to be important for Mg 2ϩ homeostasis.…”