TRPC 6 as a Molecular Target in Diabetic Nephropathy

Soni, Navneet Omprakash

doi:10.21276/ijlssr.2017.3.5.8

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…A new potential target in diabetic nephropathy has been identified. [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] The Wnt/β-catenin signaling pathway is involved in mesangial cell extracellular matrix (ECM) production (MCs). 58 Through the JNK/NF-B/NADPH oxidase/ROS pathway, high glucose promotes renal mesangial cell proliferation and fibronectin expression.…”

Section: Diabetic Nephropathymentioning

confidence: 99%

Berbamine application beyond cancer

Soni¹

2021

Int J Basic Clin Pharmacol

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The main purpose of this review was to ascertain the clinical application and future non oncological uses of Berbaminebamine (BERBAMINE). Berbaminebamine, as a STAT3 (signal transducer and activator of transcription) inhibitor, antioxidant, anti-inflammatory and modulator of many signalling pathways, should be investigated in autoimmune diseases. Berbaminebamine has been found to have pharmacological activity in the following cancers: breast cancer, lung cancer, prostate cancer, pancreatic cancer, ovarian cancer, glioblastoma, colon cancer, bladder cancer, chronic myeloid leukemia, hepatocellular carcinoma, triple negative breast cancer and osteosarcoma. Ischemic reperfusion injury, melanoma, COVID-19 and allergy diseases are among the conditions for which it is beneficial. It may aid in the treatment of obesity, metabolic syndrome, inflammatory syndrome, sepsis, COVID-19, dengue fever, Nipah virus infection, influenza, solid tumors, lymphoma, cancer, hematological malignancies, skin inflammatory disorder and atopic dermatitis. BERBAMINE can be used as versatile molecule in alcoholic liver disease, diabetic nephropathy and antiviral, anti-inflammatory.

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Section: Diabetic Nephropathymentioning

confidence: 99%

Berbamine application beyond cancer

Soni¹

2021

Int J Basic Clin Pharmacol

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“…[31] The calcium phosphate nanoparticles, which are nontoxic and biodegradable can be used to deliver drug, genes activators or siRNA or combination or multidrug if the challenges are met. further investigations must done using drug targeting precise molecular pathway in DN [33] and evaluation of evidence gave by expert and author work on pathophysiological role of TRPC 6 and the medicinal drugs which regulate or restrain TRPC6 or its downstream molecular target propose that TRPC6 is unique molecular target. [34] Oxidative Stress and Heart Disease-Traditional vascular risk factors, including hyperlipidemia (cholesterol, LDL, etc.…”

Section: Glycemic Load (Gl)-mentioning

confidence: 99%

Role of Oxidant Alteration of Biomolecules in Diabetes and Other Associated Diseases

Verma¹,

Verma²

2018

IJLSSR

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ABSTRACT-Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Physiological conditions, ROS participate in maintenance of cellular 'redox homeostasis' in order to protect cells against oxidative stress through various redox-regulatory mechanisms. Oxidative stress resulting from enhances free-radical formation and/or a defect in antioxidant defences has been implicated in the pathogenesis of diabetes and its associated complications. Diabetes mellitus comprises a group of metabolic disorders that share the common phenotype of hyperglycemia, association with the biochemical alteration of glucose and lipid peroxidation. Increase level of oxidative stress along with deranging different metabolisms; one of the Long term complications of diabetes mellitus is diabetic retinopathy, which is a leading cause of acquired blindness. Many of the recent landmarks in scientific research have shown that in human beings, oxidative stress has been implicated in the progression of major health problems by inactivating the metabolic enzymes and damaging important cellular components, oxidizing the nucleic acids, leading to cardiovascular diseases, eye disorders, joint disorders, neurological diseases (Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis), atherosclerosis, lung and kidney disorders, liver and pancreatic diseases, cancer, ageing, disease of the reproductive system including the male and female infertility etc. In this review we have the importance of endogenous antioxidant defense systems, the intense medical management; these strategies include dietary measures (antioxidants) their relationship to several pathophysiological processes and their possible therapeutic implications in vivo condition.

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TRPC 6 as a Molecular Target in Diabetic Nephropathy

Cited by 2 publications

References 17 publications

Berbamine application beyond cancer

Berbamine application beyond cancer

Role of Oxidant Alteration of Biomolecules in Diabetes and Other Associated Diseases

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