TRP proteins and cancer

Bödding, Matthias

doi:10.1016/j.cellsig.2006.08.012

Cited by 120 publications

(99 citation statements)

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“…- TRP ( Ca 2 + ) channel and TRPV5, TRPM6 genes regulate the Calcium-mediated signal transduction that is frequently altered in cancer [40]. Several genes in TRPV channel have been detected to be up-regulated in prostate, colon, and breast cancer cells [40-42].…”

Section: Resultsmentioning

confidence: 99%

“…Several genes in TRPV channel have been detected to be up-regulated in prostate, colon, and breast cancer cells [40-42]. Particularly, TRPV5 and TRPV6 genes exhibit unusually high levels of single nucleotide polymorphisms (SNPs) in African populations as compared to other populations [41].…”

Section: Resultsmentioning

confidence: 99%

“…Particularly, TRPV5 and TRPV6 genes exhibit unusually high levels of single nucleotide polymorphisms (SNPs) in African populations as compared to other populations [41]. Moreover, the genes TRPM6 and TRPM7 in the TRPM channel can enhance the secretion of angiogenic factors, for example VEGF [40], resulting in a sustained unorganized angiogenesis process. The TRP channel and TRPV5, TRPM6 genes identified in pancreatic cancer survival data could be possible targets for the future cancer diagnosis and treatment.…”

Section: Resultsmentioning

confidence: 99%

“…- KCNK ( K + ) channel and KCNK3, KCNK18 genes regulate the potassium ( K +) transport and membrane potential (Vm) in response to different physical and chemical factors [38,40]. Several KCNK channel genes, for example, KCNK9 [43], are overexpressed in breast and lung cancers, and the gene KCNK2 can promote prostate cancer cell's growth [40,44].…”

Section: Resultsmentioning

confidence: 99%

“…Several KCNK channel genes, for example, KCNK9 [43], are overexpressed in breast and lung cancers, and the gene KCNK2 can promote prostate cancer cell's growth [40,44]. …”

Section: Resultsmentioning

confidence: 99%

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Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Gong

Clarke

2014

BMC Systems Biology

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BackgroundRecent global genomic analyses identified 69 gene sets and 12 core signaling pathways genetically altered in pancreatic cancer, which is a highly malignant disease. A comprehensive understanding of the genetic signatures and signaling pathways that are directly correlated to pancreatic cancer survival will help cancer researchers to develop effective multi-gene targeted, personalized therapies for the pancreatic cancer patients at different stages. A previous work that applied a LASSO penalized regression method, which only considered individual genetic effects, identified 12 genes associated with pancreatic cancer survival.ResultsIn this work, we integrate pathway information into pancreatic cancer survival analysis. We introduce and apply a doubly regularized Cox regression model to identify both genes and signaling pathways related to pancreatic cancer survival.ConclusionsFour signaling pathways, including Ion transport, immune phagocytosis, TGFβ (spermatogenesis), regulation of DNA-dependent transcription pathways, and 15 genes within the four pathways are identified and verified to be directly correlated to pancreatic cancer survival. Our findings can help cancer researchers design new strategies for the early detection and diagnosis of pancreatic cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Several KCNK channel genes, for example, KCNK9 [43], are overexpressed in breast and lung cancers, and the gene KCNK2 can promote prostate cancer cell's growth [40,44]. …”

Section: Resultsmentioning

confidence: 99%

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Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Gong

Clarke

2014

BMC Systems Biology

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Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas

Bomben

Sontheimer

2010

Glia

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Despite decades of research, primary brain tumors, gliomas, lack effective treatment options and present a huge clinical challenge. Particularly, the most malignant subtype, Glioblastoma multiforme, proliferates extensively and cells often undergo incomplete cell divisions, resulting in multinucleated cells. We now present evidence that multinucleated glioma cells result from the functional loss of transient receptor potential canonical 1 (TRPC1) channels, plasma membrane proteins involved in agonist-induced calcium entry and reloading of intracellular Ca2+ stores. Pharmacological inhibition or shRNA mediated suppression of TRPC1 causes loss of functional channels and store-operated calcium entry in D54MG glioma cells. This is associated with reduced cell proliferation and, frequently, with incomplete cell division. The resulting multinucleated cells are reminiscent of those found in patient biopsies. In a flank tumor model, tumor size was significantly decreased when TRPC1 expression was disrupted using a doxycycline inducible shRNA knockdown approach. These results suggest that TRPC1 channels play an important role in glioma cell division most likely by regulating calcium signaling during cytokinesis.

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Transient receptor potential melastatin‐related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

Rybarczyk

Gautier

Hague

et al. 2012

Intl Journal of Cancer

130

133

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer with a tendency to invade surrounding healthy tissues, leading to a largely incurable disease. Despite many advances in modern medicine, there is still a lack of early biomarkers as well as efficient therapeutical strategies. The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation channel that is involved in maintaining Ca 21 and Mg 21 homeostasis. It has been recently reported to regulate cell differentiation, proliferation and migration. However, the role of TRPM7 in PDAC progression is far to be understood. In our study, we show that TRPM7 is 13-fold overexpressed in cancer tissues compared to the healthy ones. Furthermore, TRPM7 staining is stronger in tumors with high grade, suggesting a correlation between TRPM7 expression and PDAC progression. Importantly, TRPM7 expression is inversely related to patient survival. In BxPC-3 cell line, dialyzing the cytoplasm during the patch-clamp whole-cell recording with a 0-Mg 21 solution activated a nonselective current with a strong outward rectification. This cation current is inhibited by intracellular Mg 21 and by TRPM7 silencing. The downregulation of TRPM7 by small interference RNA dramatically inhibited intracellular Mg 21 fluorescence and cell migration without affecting cell proliferation, suggesting that TRPM7 contributes to Mg 21 entry and cell migration. Moreover, external Mg 21 following TRPM7 silencing fully restored the cell migration. In summary, our results indicate that TRPM7 is involved in the BxPC-3 cell migration via a Mg 21 -dependent mechanism and may be a potential biomarker of poor prognosis of PDAC.Pancreatic ductal adenocarcinoma (PDAC) is the fifth most frequent cause of cancer-related mortality in the European Union 1 and the the fourth most frequent cause in the United States. 2 PDAC has a poor long-term prognosis with 5-year survival rates of only 1-4%. Current therapeutic strategies generally result in only a few months of extended life because PDAC develops insidiously and metastasizes quickly and widely. Thus, a greater understanding of the molecular processes involved in PDAC progression and metastasis is urgently needed.Ion channels are transmembrane proteins that are involved in a wide panel of physiological cell mechanisms, including excitability, secretion, proliferation, apoptosis and motility. Nevertheless, a growing amount of studies show that ion channels expression is altered in several cancers including breast and prostate. 3 Among these ion channels, members of the transient receptor potential (TRP) family have been proposed as prognosis markers in breast and prostate cancers. 4,5 TRP melastatin-related 7 (TRPM7) channels are a member of ''chanzymes,'' which are unique feature of cation channels fused with a kinase function. 6,7 They allow magnesium and calcium entries; however, they are mainly involved in magnesium homeostasis. 8 In the digestive system, TRPM7 channels are expressed and involved in ...

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TRP proteins and cancer

Cited by 120 publications

References 120 publications

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas

Transient receptor potential melastatin‐related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

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