Troxerutin protects against diabetic cardiomyopathy through NF-κB/AKT/IRS1 in a rat model of type 2 diabetes

Yu, Yongzhi; Zheng, Guanzhong

doi:10.3892/mmr.2017.6456

Cited by 32 publications

(28 citation statements)

References 27 publications

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“…In vivo, Taxifolin attenuated the structure and function abnormalities by blocking NADPH oxidative activities. Troxerutin ( Figure 5(h) ), a bioflavonoid, protects against DCM through suppression of NF- κ B and JNK in a diabetic rat [ 93 ]. Hesperidin, a flavonoid isolated from citrus, has been shown to reduce oxidative stress and apoptosis and attenuate myocardial injury in isoproterenol-STZ rat via activation of PPAR- γ [ 94 ].…”

Section: Herbal Medicines: Promising Therapeutic For Dcmmentioning

confidence: 99%

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Tian

Zhao

Liu

et al. 2017

Oxidative Medicine and Cellular Longevity

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Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus. Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions. The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and impaired Ca2+ handling. An array of molecules and signaling pathways such as p38 mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), and extracellular-regulated protein kinases (ERK) take roles in the pathogenesis of DCM. Currently, there was no remarkable effect in the treatment of DCM with application of single Western medicine. The myocardial protection actions of herbs have been gearing much attention. We present a review of the progress research of herbal medicine as a potential therapy for diabetic cardiomyopathy and the underlying mechanisms.

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Section: Herbal Medicines: Promising Therapeutic For Dcmmentioning

confidence: 99%

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Tian

Zhao

Liu

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Researches over the past decades have revealed that TX can act againstγ-radiation-induced lipid peroxidation, UV radiation and colon carcinogenesis[ 28 – 30 ]. Furthermore, TX can cure retinopathy and play a significant role in the management of type-2 diabetes mellitus[ 31 – 33 ]. Beside, TX can inhibit 2-AA + UVA radiation-induced DNA damage and environmental carcinogens, showing its potential therapeutic activities for cancer[ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of gene expression in mice treated with troxerutin

et al. 2017

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Troxerutin, a semi-synthetic derivative of the natural bioflavanoid rutin, has been reported to possess many beneficial effects in human bodies, such as vasoprotection, immune support, anti-inflammation and anti-aging. However, the effects of troxerutin on genome-wide transcription in blood cells are still unknown. In order to find out effects of troxerutin on gene transcription, a high-throughput RNA sequencing was employed to analysis differential gene expression in blood cells consisting of leucocytes, erythrocytes and platelets isolated from the mice received subcutaneous injection of troxerutin. Transcriptome analysis demonstrated that the expression of only fifteen genes was significantly changed by the treatment with troxerutin, among which 5 genes were up-regulated and 10 genes were down-regulated. Bioinformatic analysis of the fifteen differentially expressed genes was made by utilizing the Gene Ontology (GO), and the differential expression induced by troxerutin was further evaluated by real-time quantitative PCR (Q-PCR).

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“…84) Many studies have shown that rutin alleviated DCM and improved cardiac function in animal models of both T1DM and T2DM. [85][86][87][88][89][90] Mechanistically, the protective effects of rutin on DCM are associated with the reduction of oxidative stress, apoptosis, and inflammation. 85) Myricitin: Myricetin is a widely distributed flavonol compound found in many plants, including tea, berries, fruits, vegetables, wines, and medicinal herbs.…”

Section: Beneficial Effects Of Nrf2 Activators On Dcmmentioning

confidence: 99%

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

Lian

Mao

et al. 2019

Int. Heart J.

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Diabetic cardiomyopathy is one of the main causes of heart failure and death in patients with diabetes mellitus. Reactive oxygen species produced excessively in diabetes mellitus cause necrosis, apoptosis, ferroptosis, inflammation, and fibrosis of the myocardium as well as impair the cardiac structure and function. It is increasingly clear that oxidative stress is a principal cause of diabetic cardiomyopathy. The transcription factor nuclear factor-erythroid 2 p45-related factor 2 (NRF2) activates the transcription of more than 200 genes in the human genome. Most of the proteins translated from these genes possess anti-oxidant, anti-inflammatory, antiapoptotic, anti-ferroptotic, and anti-fibrotic actions. There is a growing body of evidence indicating that NRF2 and its target genes are crucial in preventing high glucose-induced oxidative damage in diabetic cardiomyopathy. Recently, many natural and synthetic activators of NRF2 are shown to possess promising therapeutic effects on diabetic cardiomyopathy in animal models of diabetic cardiomyopathy. Targeting NRF2 signaling by pharmacological entities is a potential approach to ameliorating diabetic cardiomyopathy. However, the persistent high expression of NRF2 in cancer tissues also protects the growth of cancer cells. This "dark side" of NRF2 increases the challenges of using NRF2 activators to treat diabetic cardiomyopathy. In addition, some NRF2 activators were found to have off-target effects. In this review, we summarize the current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathy.

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Troxerutin protects against diabetic cardiomyopathy through NF-κB/AKT/IRS1 in a rat model of type 2 diabetes

Cited by 32 publications

References 27 publications

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Transcriptomic analysis of gene expression in mice treated with troxerutin

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

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