Troxerutin downregulates C/EBP‐β gene expression via modulating the IFNγ‐ERK1/2 signaling pathway to ameliorate rotenone‐induced retinal neurodegeneration

Ibrahim, Rowida Raafat; El‐Esawy, Rasha Osama; El‐Sakaa, Mervat H.

doi:10.1002/jbt.22482

Cited by 5 publications

(3 citation statements)

References 62 publications

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“…Recent in vitro experiments have shown that EGCG and its metabolites, such as theaflavins, can enter the brain parenchyma through the BBB, induce neuritogenesis and have a potential neuroprotective effect [20]. Troxerutin, a natural flavonoid with a high capability to pass through the BBB, can prevent rotenone-induced retinal neurodegeneration [21]. Quercetin, a flavonoid, has obvious neuroprotective effects on radioactive brain injury [22].…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Wang

Xie

et al. 2020

Molecules

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Patients receiving brain radiotherapy may suffer acute or chronic side effects. Ionizing radiation induces the production of intracellular reactive oxygen species and pro-inflammatory cytokines in the central nervous system, leading to brain damage. Complementary Chinese herbal medicine therapy may reduce radiotherapy-induced side effects. Flavonoids are a class of natural products which can be extracted from Chinese herbal medicine and have been shown to have neuroprotective and radioprotective properties. Flavonoids are effective antioxidants and can also inhibit regulatory enzymes or transcription factors important for controlling inflammatory mediators, affect oxidative stress through DNA interactions and enhance genomic stability. In this paper, radiation-induced brain damage and the relevant molecular mechanism were summarized. The radio-neuro-protective effect of flavonoids, i.e., antioxidant, anti-inflammatory and maintaining genomic stability, were then reviewed. We concluded that flavonoids treatment may be a promising complementary therapy to prevent radiotherapy-induced brain pathophysiological changes and cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Wang

Xie

et al. 2020

Molecules

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“…Different kinds of radioprotective products have been discovered, including polyphenols, anthocyanins, and polysaccharides. 18,29,30 In China, L. lancifolium Thunb . is widely grown for its edible bulbs, which is considered a vegetable with high nutritional value.…”

Section: Discussionmentioning

confidence: 99%

Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks

et al. 2022

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Background Radiotherapy is widely used in the treatment of tumors. However, while killing tumor cells, radiation may also cause damage to the surrounding normal tissues. Therefore, it is very important to find safe and effective radiation protection agents. Purpose To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP). Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism. Results The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection. In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL. Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs. Conclusion These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.

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“…Flavonoids are also anti-inflammatory scavengers of free radicals. Flavonoids are plant-derived compounds that exist naturally in various Chinese medicines, and exhibit radioprotective and neuroprotective properties [ 175 , 176 , 177 , 178 ]. Both flavonoids and their metabolites can cross the blood–brain barrier [ 179 ], which is composed of capillary endothelial cells, basement and neuroglial membranes, and glial podocytes [ 180 ], and approach brain cells to decrease brain injury, while improving neurodegenerative diseases and cognitive impairment [ 181 , 182 , 183 ].…”

Section: Biological Effects Of Microwavesmentioning

confidence: 99%

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

Mumtaz

Rana

Choi

et al. 2022

IJMS

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Modern humanity wades daily through various radiations, resulting in frequent exposure and causing potentially important biological effects. Among them, the brain is the organ most sensitive to electromagnetic radiation (EMR) exposure. Despite numerous correlated studies, critical unknowns surround the different parameters used, including operational frequency, power density (i.e., energy dose), and irradiation time that could permit reproducibility and comparability between analyses. Furthermore, the interactions of EMR with biological systems and its precise mechanisms remain poorly characterized. In this review, recent approaches examining the effects of microwave radiations on the brain, specifically learning and memory capabilities, as well as the mechanisms of brain dysfunction with exposure as reported in the literature, are analyzed and interpreted to provide prospective views for future research directed at this important and novel medical technology for developing preventive and therapeutic strategies on brain degeneration caused by microwave radiation. Additionally, the interactions of microwaves with biological systems and possible mechanisms are presented in this review. Treatment with natural products and safe techniques to reduce harm to organs have become essential components of daily life, and some promising techniques to treat cancers and their radioprotective effects are summarized as well. This review can serve as a platform for researchers to understand the mechanism and interactions of microwave radiation with biological systems, the present scenario, and prospects for future studies on the effect of microwaves on the brain.

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Troxerutin downregulates C/EBP‐β gene expression via modulating the IFNγ‐ERK1/2 signaling pathway to ameliorate rotenone‐induced retinal neurodegeneration

Cited by 5 publications

References 62 publications

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks

Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

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