Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats

Gao, Chao; Song, Yunfei; Dou, Taotao; Jiang, Shuai; Wu, H; Seshadri, Vidya Devanathadesikan; Veeraraghavan, Vishnu Priya; Hou, Pengfei

doi:10.1615/jenvironpatholtoxicoloncol.2021038860

Cited by 5 publications

(2 citation statements)

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“…However, mice supplemented with TRX 300 mg/kg/b.w showed a significantly lower MDA level in serum. Our results are similar to previous studies such as Gao et al (2021), which also indicated that supplementation of mice with 10 and 20 mg/kg/ b.w TRX for seven days mitigates the cerebral ischemic reperfusion damage induced oxidative stress by decreasing the MDA level in the brain. Nitric oxide deficient hypertensive rats, when treated with 100 mg/kg/b.w TRX for one month, exhibited ample potential to upgrade antioxidant properties and reduce the generation of lipid peroxidation (Raja et al 2019).…”

Section: Discussionsupporting

confidence: 92%

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Neuro-protective and redox potential of troxerutin against cypermethrin-induced neurotoxicity and oxidative stress in mice

Shehzad,

Farooq,

Tahir

et al. 2024

Polish Journal of Veterinary Sciences

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The present study was designed to evaluate the protective efficacy of troxerutin against cypermethrin-induced behavioral defects, motor function abnormalities, and oxidative stress in mice. Twenty-four adult female albino mice were randomly divided into four equal groups. The first group served as control, the second group was treated with cypermethrin (20 mg/kg b.w) intraperitoneally at day 21, and the remaining two groups were orally supplemented with TRX (150, 300 mg/kg b.w) for 20 days and with cypermethrin (20 mg/kg b.w) intraperitoneally at day 21. Behavior activities recorded after cypermethrin exposure showed significantly impaired motor function (p≤0.05) as evidenced by the beam balance and pole test. The cypermethrin was also found to cause significant memory dysfunction. Moreover, the oxidative stress in terms of increased tissue malondialdehyde level (p≤0.05) was recorded in the cypermethrin group. The antioxidant activities of catalase and glutathione peroxidase were decreased (p≤0.05) after cypermethrin exposure. Troxerutin supplementation significantly improved the cypermethrin- -induced motor impairment and memory dysfunction. The supplementation of troxerutin significantly restored the redox status. Troxerutin attenuates the neurotoxic and behavioral deficits caused by cypermethrin. Furthermore, troxerutin also provides significant protection against cypermethrin-induced oxidative stress by improving the oxidative stress markers.

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Section: Discussionsupporting

confidence: 92%

“…This is because troxerutin plays a crucial role in restoring the activities of the antioxidant enzymes. Another study conducted by Gao et al (2021) on rats also supports this data. According to this study, the ischemic/reperfusion induced brain injured rats, when treated with troxerutin (10 and 20 mg/kg/b.w.)…”

Section: Discussionsupporting

confidence: 69%