Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome

Xu, Hui; Dong, Jiangtao; Li, Yang; Zhang, Lei; Yin, Jiangwen; Zhu, Chao; Wang, Xu; Ren, Kunhao; Zhang, Hao; Zhao, Dong

doi:10.1016/j.jstrokecerebrovasdis.2023.107391

Cited by 1 publication

(2 citation statements)

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“…Our previous studies on the mechanism of Neuritin on the apoptotic pathway of ER stress found that ER stress is not only closely related to apoptosis (Zhang et al 2017), but also has a strong link with in ammation (Xu et al 2023). Neuritin is a member of the neurotrophic factor family, which can be triggered by neuronal activity and neurotrophic factors to promote neural synapse growth and branching.…”

Section: Discussionmentioning

confidence: 99%

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Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways

Ren,

Dai,

Zhang

et al. 2024

Preprint

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Neuroinflammation is a key destructive pathophysiological process in early brain injury (EBI) following subarachnoid hemorrhage (SAH). Recent studies have discovered that endoplasmic reticulum stress-related inflammatory pathways include the IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT -NF-κB pathway leading to neuroinflammatory response. Neuritin is a neurotrophin that is involved in neuronal plasticity and regeneration. Studies have suggested that Neuritin has a vital role in reducing neuroinflammation, and can also decrease the expression of proteins related to endoplasmic reticulum stress following SAH. This suggests that Neuritin could be a potential therapeutic target for SAH and other neurological conditions. However, the regulatory mechanisms of Neuritin in ER stress-related inflammatory pathways after SAH are not yet fully understood. In this work, we discovered that the activation of ER stress-related inflammatory pathways leads to neuroinflammation, which further aggravates neuronal apoptosis after SAH. Our findings indicate that Neuritin overexpression play a neuroprotective role by inhibiting IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT-NF-κB pathway associated with endoplasmic reticulum stress. These inhibitory effects on neuroinflammation ultimately reduce nerve cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

“…We have demonstrated that Neuritin inhibited the formation of NLRP3 in ammasome following cerebral ischemia, consequently reducing neuroin ammation (Xu et al 2023). Neuritin, an activity-induced neurotrophic factor discovered in 1993, plays a key role in promoting neurite growth.…”

Section: Introductionmentioning

confidence: 86%

Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways

Ren,

Dai,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome

Cited by 1 publication

References 44 publications

Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways

Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways

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