Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report

Aoyama, Kohji; Tamura, Masashi; Uchibori, Masahiro; Nakanishi, Yoichi; Arai, Toshihiro; Aoki, Takayuki; Osawa, Yuko; Kaneko, Akihiro; Ota, Yoshihide

doi:10.1186/s13256-018-1833-6

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Similar to the murine OSCC cell line in the present study, human OSCC cells have clearly established pro-aggregatory phenotype in vivo and in vitro. OSCC tumors are implicated in local thrombosis events, especially internal jugular vein thrombosis [43] and even carotid artery thrombosis [44]. However, no augmentation of the systemic thrombosis risk occurs in humans with OSCC [19], suggesting that a mechanism to counteract the thrombotic potential of OSCC exists in humans.…”

Section: Discussionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

et al. 2021

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Venous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and it represents approximately 2.1% of all cancers worldwide. Most tumors are squamous cell carcinomas and are mainly due to tobacco and alcohol abuse. VTE risk associated with oral squamous cell carcinoma (OSCC) is low. However, many studies have shown that OSCC has the following biological features of cancers associated with a high thrombosis risk: modified thrombosis and fibrinolysis mechanisms; strong expression of procoagulant proteins; secretion of procoagulant microparticles; and production of procoagulant cytokines. Using an original mouse model of tongue squamous cell carcinoma, our study aimed to clarify this paradoxical situation. First, we showed that OSCC tumors have a pro-aggregatory phenotype and a high local thrombosis risk. Second, we found that tongue tumor mice do not have an elevated systemic thrombosis risk (the risk of an “at distance” thrombosis event such as lower extremity deep venous thrombosis or pulmonary embolism) and even show a reduction in risk. Third, we demonstrated that tongue tumor mice show a reduction in platelet reactivity, which explains the low systemic thrombosis risk. Finally, we found that tongue tumor mice present granule pool deficiency, thereby explaining the reduction in platelet reactivity and systemic thrombosis risk.

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Section: Discussionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

et al. 2021

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Clinical features of Trousseau’s syndrome with multiple acute ischemic strokes

Ling

Zhang

et al. 2021

Neurol Sci

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Background:Trousseau's syndrome can cause venous or arterial thrombosis, multiple acute ischemic strokes (MAIS) caused by Trousseau's syndrome is rare. The aim of this study was to analyze the clinical features of Trousseau's syndrome with MAIS, and to improve the awareness and the knowledge of this disease. Methods:Clinical data from fteen patients who were diagnosed as Trousseau's Syndrome with MAIS in Rizhao people's Hospital from January 2017 to April 2020 were collected and analyzed. The clinical data included the following: Patients' basic information, laboratory results, imaging features, treatment regimens, and short-term prognoses were collected. Results :The mean age was 65.5 years, with thirteen males and two females. Most patients (11/15) had a history of smoking and (or) drinking.The average score of NIHSS was 2.13. 6 of the 15 patients rst presented with ischemic stroke, and then found the primary tumor. Most common types of primary tumor was lung cancer (11/15), other types of primary tumor were gastric adenocarcinoma, renal cell carcinoma, esophageal adenosquamous carcinoma, and cholangiocarcinoma (one in each). All the 15 patients showed different levels of increase of D-dimer. The increase in CRP appears in 10 of the 15 patients. Various tumor markers were increased in the 15 patients, Especially for CYFRA-211, all the patients of which were higher than normal. All of the 15 patients had multiple vascular territories lesions in DWI, and most lesions were near the cortex areas. Only 4 of the 15 patients (26.7%) occurred with Peripheral venous thrombosis. 13 patients were given low molecular heparin for anticoagulant therapy, of which 9 patients were improved in short-term while 4 patients were not. Conclusion:Trousseau's syndrome with MAIS was associated with old-age male, smoking and (or) drinking history, low NIHSS score, increased Ddimer, CRP and tumor markers, lesions near the cortex areas with multiple vascular territories in DWI. Patients with these features should be alert of malignant tumor. Most common types of primary tumor were lung cancer. Treatment with Low molecular heparin may be effective in short-term. BackgroundTrousseau's syndrome was rst described in 1865 as the relationship between venous thromboembolisms and cancer [1]. Sack et al. extended this de nition to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarpditis, and arterial embolism in patients with cancer [2]. Multiple acute ischemic strokes (MAIS) is a rare manifestation of Trousseau's syndrome, usually involvingelevation of D-dimer levels and acute simultaneous multiple embolisms in multiple vascular territories. There have been few large series studies on Clinical features of Trousseau's syndrome with MAIS. Here, we summarized and analyzed the clinical manifestations, laboratory results and brain magnetic resonance images (MRI) features of fteen patients who were diagnosed as Trousseau's Syndrome with MAIS in our hospital to improve the awareness and early diagn...

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An autopsy case of Trousseau’s syndrome with tumor thrombosis in unknown primary squamous cell carcinoma of the head and neck

Uraguchi

Kozakura²,

Fukuda

et al. 2020

Int Canc Conf J

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Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report

Cited by 6 publications

References 24 publications

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

Clinical features of Trousseau’s syndrome with multiple acute ischemic strokes

An autopsy case of Trousseau’s syndrome with tumor thrombosis in unknown primary squamous cell carcinoma of the head and neck

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