Trough to peak ratio of once-daily lisinopril and twice-daily captopril in patients with essential hypertension

Abstract

The objective of this study was to assess the antihypertensive effect and the trough to peak (T:P) ratio of lisinopril and captopril, in patients with essential hypertension.After 2 weeks of placebo, 69 of 115 eligible patients had office diastolic blood pressure (DBP) between 90 and 114 mm Hg and daytime average DBP above 85 mm Hg during a 25-h ambulatory BP monitoring (ABPM) and were randomised to receive lisinopril (20 mg once daily) or captopril (50 mg twice daily) for 4 weeks. Office and ambulatory BP were then repeated. Indices of 24-h BP and T:P ratios were calculated and compared.

Efficacy and safety of twice‐ vs once‐daily dosing of lisinopril for hypertension

“…Thus, some patients may not get complete 24‐hour BP control with once‐daily lisinopril. Interestingly, previous research using 24‐hour ambulatory BP monitoring has suggested that once‐daily lisinopril dosing is associated with a trough to peak ratio of 0.75, which is generally considered favorable for once‐daily administration of antihypertensives . Whether and to what extent twice‐daily lisinopril dosing improves on this trough to peak ratio is not known.…”

2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension

“…Drug therapy is initiated at a low dose to avoid adverse effects. The preferred drugs are long-acting and can be taken only once a day [ 130 ]. Drugs with a high trough/peak ratio (T/P ratio > 0.5) are helpful for improving adherence and to maintain a stable BP with minimal variability [ 131 ].…”

2013 Korean Society of Hypertension guidelines for the management of hypertension. Part II—treatments of hypertension

“…Drug therapy is initiated at a low dose to avoid adverse effects. The preferred drugs are long-acting and can be taken only once a day [ 64 ]. Drugs with a high trough/peak ratio (>0.5) are helpful for improving compliance and to maintain a stable BP with minimal variability [ 65 ].…”