Troponin in diabetic patients with and without chronic coronary artery disease

Segre, Carlos Alexandre Wainrober; Hueb, Whady; Garcia, Rosa Wanda Diez; Rezende, Paulo Cury; Favarato, Desidério; Sprandel, Marília da Costa Oliveira; Roggério, Alessandra; Carvalho, Ana Maria Almeida; Maranhão, Raul C.; Ramires, José Antônio Franchini; Filho, Roberto Kalil

doi:10.1186/s12872-015-0051-z

Cited by 36 publications

(25 citation statements)

References 40 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Troponin I, but not brain natriuretic peptide, has been shown to be elevated in human patients with DM and coronary disease (Segre et al 2015). Therefore, cTnI appears to be the most promising biomarker for assessing the impact of DM on cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

Cardiac troponin I, fructosamine, and cardiovascular parameters in dogs with diabetes mellitus

Soares

Machado

Carvalho

et al. 2018

Austral j. vet. sci.

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a common endocrinopathy in dogs, however, the relationship between canine DM and cardiomyopathy is still unclear. The aims of this study were: to evaluate serum troponin I concentrations in diabetic dogs under treatment with insulin; to evaluate the hypothesis that the time of DM diagnosis could influence the troponin I concentration; and to evaluate the relationship between biochemical and cardiovascular parameters in diabetic dogs. This is a cross-sectional study including diabetic canine patients under NPH insulin treatment. Troponin I concentration, systolic blood pressure (SBP), complete blood count, serum fructosamine concentration, biochemical profile, and Doppler echocardiography assesments were carried out in each patient, as well as in age-and size-matched healthy controls. All diabetic dogs had concentrations of troponin I below the limits of detection of the assay. There was no difference between cardiovascular parameters between diabetic and healthy control dogs. There was no correlation between time of DM diagnosis and cardiovascular parameters. There was a significant positive correlation between SBP and fructosamine in diabetic dogs (r=0.54; P<0.01). Diabetic dogs receiving insulin treatment, regardless of the time of diagnosis, do not have significantly elevated serum troponin I. The results also suggest that fructosamine levels can be associated with high blood pressure, suggesting a possible correlation between fructosamine levels and vascular complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac troponin I, fructosamine, and cardiovascular parameters in dogs with diabetes mellitus

Soares

Machado

Carvalho

et al. 2018

Austral j. vet. sci.

View full text Add to dashboard Cite

show abstract

“…It has been shown that in diabetic patients with multiple associated cardiovascular risk factors, troponin may be used as a CVD biomarker. [ 21 ] Lin-Tan et al . showed that basal fasting glucose levels play an important role in short-term mortality of diabetic maintenance HD patients.…”

Section: Discussionmentioning

confidence: 99%

Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients

Taheri¹,

Pilehvarian²,

Akbari³

et al. 2016

J Res Pharm Pract

View full text Add to dashboard Cite

Objective:Patients on hemodialysis (HD) have a high risk for cardiovascular morbidity and mortality. Cardiac troponins are biomarkers for diagnosing acute myocardial injury or infarction. There is considerable controversy that exists in the frequency and significance of cardiac troponins in predicting cardiac injury and ischemia in HD patients.Methods:In this cross-sectional study, all HD patients more than 18-year-old, who were at least 3 months under HD, and had no sign and symptom of active cardiovascular disease (CVD), in two HD centers were enrolled. One hundred and one patients fulfilled the inclusion criteria. Blood sample for cardiac troponin I (cTnI) was drown before the initiation of HD session during their routine monthly blood testing from patients’ vascular access arterial line. cTnI levels were measured by a high-sensitivity assay, VIDAS troponin I Ultra kit, and correlated with patients’ demographic, clinical, and laboratory results.Findings:The patients’ different demographic and clinical characteristics had no statistically significant correlation with troponin levels except for marginal trend for past medical history of diabetes and hyperlipidemia with corresponding P values of 0.072 and 0.055. Twenty-six patients had cTnI level more than 0.01 ΅g/L and only two patients had cTnI level more than 0.11 ΅g/L. For laboratory results, only fasting blood sugar had statistically significant correlation with patients’ cTnI level (r = 0.357, P = 0.0001).Conclusion:Frequency of significant elevation of cTnI level in our asymptomatic HD patients was very low and if such elevation is found in this population, it may be considered as a sign of active CVD.

show abstract

“…Elevated levels of 3-NT have been also found in a variety of human diseases in recent research, including T2D, cancer, and neurodegenerative diseases, but the available data are partially conflicting ( Table 7 ). For instance, while Ravassa et al found higher 3-NT levels in T2D patients with additional cardiovascular events, no differences were observed by Segre and colleagues although baseline parameters of the study populations and the used methods were similar [ 189 , 190 ]. Moreover, recent research in AD patients revealed higher 3-NT levels compared to healthy volunteers, whereas no differences were found in a previous investigation by Ryberg and colleagues, but these studies are only partially comparable since different specimens and methodological approaches have been used [ 151 , [191] , [192] , [193] ].…”

Section: The Relevance Of Biomarkers Of Protein Oxidation In the Context Of Human Disease And Agingmentioning

confidence: 99%

Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases

et al. 2021

View full text Add to dashboard Cite

Generation of reactive oxygen species and related oxidants is an inevitable consequence of life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates with oxidants and their high abundance in cells, extracellular tissues, and body fluids. Additionally, oxidative stress is able to degrade lipids and carbohydrates to highly reactive intermediates, which eventually attack proteins at various functional sites. Consequently, a wide variety of distinct posttranslational protein modifications is formed by protein oxidation, glycoxidation, and lipoxidation. Reversible modifications are relevant in physiological processes and constitute signaling mechanisms (“redox signaling”), while non-reversible modifications may contribute to pathological situations and several diseases. A rising number of publications provide evidence for their involvement in the onset and progression of diseases as well as aging processes. Certain protein oxidation products are chemically stable and formed in large quantity, which makes them promising candidates to become biomarkers of oxidative damage. Moreover, progress in the development of detection and quantification methods facilitates analysis time and effort and contributes to their future applicability in clinical routine. The present review outlines the most important classes and selected examples of oxidative protein modifications, elucidates the chemistry beyond their formation and discusses available methods for detection and analysis. Furthermore, the relevance and potential of protein modifications as biomarkers in the context of disease and aging is summarized.

show abstract

Troponin in diabetic patients with and without chronic coronary artery disease

Cited by 36 publications

References 40 publications

Cardiac troponin I, fructosamine, and cardiovascular parameters in dogs with diabetes mellitus

Cardiac troponin I, fructosamine, and cardiovascular parameters in dogs with diabetes mellitus

Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients

Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases

Contact Info

Product

Resources

About