Tropical pyomyositis: an update

Shittu, Adebayo; Deinhardt‐Emmer, Stefanie; Nunes, Jonathan Vas; Niemann, Silke; Grobusch, Martin P.; Schaumburg, Frieder

doi:10.1111/tmi.13395

Cited by 26 publications

(19 citation statements)

References 47 publications

(76 reference statements)

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“…Panton–Valentine leukocidin is a pore-forming protein consisting of two sub-units (lukF-PV, lukS-PV) that target human granulocytes, monocytes, and macrophages ( Holzinger et al, 2012 ). It is mainly associated with skin and soft tissue infection (SSTI) ( Friesen et al, 2020 ), and in particular, pyomyositis in developing countries ( Shittu et al, 2020a ). This study identified PVL-positive MRSA from nine CCs in 10 countries.…”

Section: Discussionmentioning

confidence: 99%

A 6-Year Update on the Diversity of Methicillin-Resistant Staphylococcus aureus Clones in Africa: A Systematic Review

et al. 2022

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BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital-associated (HA) and community-associated (CA) infections globally. The multi-drug resistant nature of this pathogen and its capacity to cause outbreaks in hospital and community settings highlight the need for effective interventions, including its surveillance for prevention and control. This study provides an update on the clonal distribution of MRSA in Africa.MethodsA systematic review was conducted by screening for eligible English, French, and Arabic articles from November 2014 to December 2020, using six electronic databases (PubMed, EBSCOhost, Web of Science, Scopus, African Journals Online, and Google Scholar). Data were retrieved and analyzed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines (registered at PROSPERO: CRD42021277238). Genotyping data was based primarily on multilocus sequence types (STs) and Staphylococcal Cassette Chromosome mec (SCCmec) types. We utilized the Phyloviz algorithm in the cluster analysis and categorization of the MRSA STs into various clonal complexes (CCs).ResultsWe identified 65 studies and 26 publications from 16 of 54 (30%) African countries that provided sufficient genotyping data. MRSA with diverse staphylococcal protein A (spa) and SCCmec types in CC5 and CC8 were reported across the continent. The ST5-IV [2B] and ST8-IV [2B] were dominant clones in Angola and the Democratic Republic of Congo (DRC), respectively. Also, ST88-IV [2B] was widely distributed across the continent, particularly in three Portuguese-speaking countries (Angola, Cape Verde, and São Tomé and Príncipe). The ST80-IV [2B] was described in Algeria and Egypt, while the HA-ST239/ST241-III [3A] was only identified in Egypt, Ghana, Kenya, and South Africa. ST152-MRSA was documented in the DRC, Kenya, Nigeria, and South Africa. Panton–Valentine leukocidin (PVL)-positive MRSA was observed in several CCs across the continent. The median prevalence of PVL-positive MRSA was 33% (ranged from 0 to 77%; n = 15).ConclusionWe observed an increase in the distribution of ST1, ST22, and ST152, but a decline of ST239/241 in Africa. Data on MRSA clones in Africa is still limited. There is a need to strengthen genomic surveillance capacity based on a “One-Health” strategy to prevent and control MRSA in Africa.

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Section: Discussionmentioning

confidence: 99%

A 6-Year Update on the Diversity of Methicillin-Resistant Staphylococcus aureus Clones in Africa: A Systematic Review

et al. 2022

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“…Although the pathogenesis is unclear, it seems that iron release from damaged muscle provides nutrients for the rapid growth of bacteria within the tissue. 9,10 It is not uncommon for patients to report strenuous exercise several hours or days before its onset. 11,12 The most frequently compromised muscles are in the lower extremities, especially the femoral quadriceps, iliopsoas and buttocks.…”

Section: Discussionmentioning

confidence: 99%

Septic emboli from pyomyositis

et al. 2020

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Pyomyositis commonly presents with fever, muscle pain and abscess formation involving deep soft-tissue compartments. Staphylococcus aureus is the main causative organism and diagnosis is usually established clinically, supported by imaging, but confirmation may be achieved by histopathological examination. Broad-spectrum antibiotic therapy and surgical debridement are the cornerstone of treatment. Its prognosis is good but, as in all soft-tissue infections, it depends on early intervention, directed antibiotics and, if indicated, prompt surgery. In this paper, we describe a case of pelvic pyomyositis complicated with bacteraemia and bilateral septic pulmonary emboli in a young man in Colombia.

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“…12 and 13). 22 The risk factors include diabetes, immunocompromised states, intravenous drug use, cellulitis and penetrating injuries. However patients with no significant history can also be affected, and there is a higher incidence among children and young adults.…”

Section: Infectionmentioning

confidence: 99%