Present erosion and sediment flux in the semiarid intramontane Santa Maria Basin, NW Argentina, are compared with conditions during a period of wetter and more variable climate at about 30,000 14 C yr ago. The results suggest that the influence of climate change on the overall erosional sediment budget is significant, mainly because of a change in the erosion regime coupled with an increase in mass movements. The most effective mechanism to increase landslide activity in this environment is a highly variable climate on interannual timescales. In contrast, Quaternary changes in erosional budgets due to variations in moisture regimes is small in the Santa Maria Basin. Because the magnitude of a potential increase in background erosion as well as enhanced landsliding is smaller than typical levels of uncertainty of erosional budgets for such large basins, it is not likely that climate-driven erosional unloading can influence tectonic style and rates in this semiarid environment on time scales of several thousands to a few tens of thousands of years.