Trophoblastic disease: Twenty years' experience at Niigata University

Abstract

The author engaged in the registration work and the clinical studies of trophoblastic disease over 20 years at Niigata University in Niigata prefecture, before transferring to University of the Ryukyus in Okinawa prefecture in 1992. In this paper, the following four topics are reviewed and discussed. 1) the registration data of trophoblastic disease in Niigata prefecture, 2) the treatment results of gestational chorio-carcinoma at the Niigata University Hospital, 3) a trial administration of Gn-RH analogue in patients with gestational choriocarcinoma to suppress secretion of hCG-like substance (hLS) which might cross-react anti-hCG antibodies in hCG immunoassay system, 4) the two rare cases of extrauterine gestational choriocarcinoma who were presented to the Ryukyus University Hospital.

Extrauterine choriocarcinoma of the greater omentum after tubal pregnancy: case report

“…Careful review on histologic specimen of the greater omentum lesion revealed a choriocarcinoma (Figs. 1,2). At that time, the serum b-hCG level was 6,600 IU/L.…”

“…In the majority of cases, the carcinomatous tissues fill out the uterine cavity, or they grow in the form of nodes deep in the uterine wall. The primary extrauterine localization of this tumor is very rare, with only a few cases (2–8) reported in the literature. Extrauterine choriocarcinoma is found mostly in the genital tract (tube, ovary, cervix, and vagina).…”

Extrauterine choriocarcinoma of the greater omentum after tubal pregnancy: case report

“…In the majority of cases, the carcinomatous tissues fill out the uterine cavity, or they grow in the form of nodes deep in the uterine wall. The primary extrauterine localization of this tumor is very rare, with only a few cases (2)(3)(4)(5)(6)(7)(8) reported in the literature. Extrauterine choriocarcinoma is found mostly in the genital tract (tube, ovary, cervix, and vagina).…”