Trombositten zengin Fibrinin periferik sinir iyileşmesi üzerindeki histopatolojik etkileri

Metineren, Hasan; Dülgeroğlu, Turan Cihan; Metineren, Mehmet Hüseyin

doi:10.5798/dicletip.338997

Cited by 2 publications

(1 citation statement)

References 20 publications

(18 reference statements)

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“…The most preferred enrichment methods developed to benefit from the mentioned features of platelets are classical PRP and PRF 17 . One study examined the effects of PRF on the sciatic nerve healing model and found that PRF had an accelerating and complementary effect on peripheral nerve healing histologically 18 . In vitro studies showed that the factors released by PRP and PRF activate the adipose-derived stem cells and chemotaxis of these cells 6 .…”

Section: Discussionmentioning

confidence: 99%

The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats

Kastamoni

YAVAŞ

Özgenel

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: One of the most important factors that adversely affects the outcome of peripheral nerve surgery is the formation of epineural and extraneural scar tissue after surgery. Many surgical methods and pharmacological and chemical agents have been used to prevent the formation of epineural scar tissue, but satisfactory results have not been achieved in clinical applications. The purpose of this study was to investigate the combined effect of fat graft and platelet-rich fibrin on the formation of epineural scar tissue and on nerve healing in the mature rat model. METHODS: A total of 24 female Sprague-Dawley rats were used. A circumferential segment of epineurium was excised from both bilateral sciatic nerves. The epineurectomized right nerve segment was wrapped with a combination of fat graft and platelet-rich fibrin (experimental group), while the left nerve segment did not receive any surgical procedure other than the epineurectomy (sham group). Notably, 12 randomly selected rats were sacrificed in the fourth week for histopathological examination of early results. The other 12 rats were sacrificed in the eighth week for late results. RESULTS: The formation of fibrosis, inflammation, and myelin degeneration were less common in the experimental group, while nerve regeneration was found to be higher at both 4 and 8 weeks. CONCLUSION: The intraoperative application of a combination of fat graft and platelet-rich fibrin appears to be effective on nerve healing after surgery at both the early and late periods.

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Section: Discussionmentioning

confidence: 99%

The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats

Kastamoni

YAVAŞ

Özgenel

et al. 2023

Rev. Assoc. Med. Bras.

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Siyatik sinir yaralanması oluşturulan ratlarda Andız (Juniperus sp) kökü ekstraktının ve B12 vitamininin sinir iyileşmesi üzerine etkisinin karşılaştırılması

SANCAK,

ÇETİN

2023

Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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The self-repair capacity of peripheral nerves is limited, and the repair of severely damaged or significantly flawed nerves is challenging. For preclinical investigations on peripheral nerve regeneration, the sciatic nerve injury model is the most often used experimental model. In rats, sciatic nerve injury is the most frequently used model in studies related to peripheral nerve regeneration. Material and Methods: In this study, 32 rats were subjected to sciatic nerve injury, and applications of B12 vitamin and Andız root extract were performed. After the applications, the rats were sacrificed on the 21st day, and samples of the sciatic nerve tissue were taken. The collected samples were examined using histopathological and immunofluorescence methods. Results: The examination revealed that B12 vitamin and Andız root extract, when applied separately to the rats, provided limited and similar benefits histopathologically, while the group that received combined treatment showed more effective positive effects compared to all other groups. Additionally, when assessing S100 and GFAP expression through immunofluorescence, it was observed that individual applications provided similar benefits, while the group that received combined treatment contributed more effectively compared to all other groups. Conclusion: In conclusion, in the rat model of sciatic nerve injury, it was determined that Andız root extract and B12 vitamin, when applied separately, had limited and similar effects compared to the control group in determining the levels of recovery. However, when applied together, they exhibited a synergistic effect, providing a greater contribution to nerve regeneration compared to all other groups.

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Trombositten zengin Fibrinin periferik sinir iyileşmesi üzerindeki histopatolojik etkileri

Cited by 2 publications

References 20 publications

The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats

The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats

Siyatik sinir yaralanması oluşturulan ratlarda Andız (Juniperus sp) kökü ekstraktının ve B12 vitamininin sinir iyileşmesi üzerine etkisinin karşılaştırılması

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