Trojan Genes and Transparent Genomes: Sexual Selection, Regulatory Evolution and the Real Hopeful Monsters

Rollo, C. David

doi:10.1007/s11692-014-9276-5

Cited by 2 publications

(1 citation statement)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The trade-off between production and stress resistance/longevity assurance also underpins Kirkwood and Holliday's disposable soma theory (see Kirkwood 2008). Holliday (1989) argued that the dietary restriction response is a form of adaptive plasticity, and regulation of this reaction norm traces to TOR-FOXO antagonism conserved from yeast to vertebrates (Rollo 2010(Rollo , 2014. In this framework, our results suggest that metformin acts as a hormetic stressor, whereas the active derivative of aspirin, salicylic acid, may act as a regulator of conserved elements in animal longevity assurance pathways.…”

Section: Introductionmentioning

confidence: 99%

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

Hans

Lone

Aksenov

et al. 2015

AGE

Self Cite

View full text Add to dashboard Cite

We examined the impacts of aspirin and metformin on the life history of the cricket Acheta domesticus (growth rate, maturation time, mature body size, survivorship, and maximal longevity). Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls). Increases in general survivorship were even more pronounced, with low-dose aspirin yielding mean longevity 234 % of controls (i.e., health span). Metformin strongly reduced growth rates of both genders (<60 % of controls), whereas aspirin only slightly reduced the growth rate of females and slightly increased that of males. Both drugs delayed maturation age relative to controls, but metformin had a much greater impact (>140 % of controls) than aspirin (~118 % of controls). Crickets maturing on low aspirin showed no evidence of a trade-off between maturation mass and life extension. Remarkably, by 100 days of age, aspirin-treated females were significantly larger than controls (largely reflecting egg complement). Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of Beat more, live longer.^In contrast, metformin-treated females were only~67 % of the mass of controls. Our results suggest that hormetic agents like metformin may derive significant trade-offs with life extension, whereas health and longevity benefits may be obtained with less cost by agents like aspirin that regulate geroprotective pathways.

show abstract

Section: Introductionmentioning

confidence: 99%