tRNA binding with anti-cancer alkaloids–nature of interaction and comparison with DNA–alkaloids adducts

Tyagi, Gunjan; Agarwal, Shweta; Mehrotra, Ranjana

doi:10.1016/j.jphotobiol.2014.12.009

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Therapeutic Strategies Via Targeting Trna Methylation Modifi...1

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Cited by 10 publications

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“…Tamoxifen and its metabolites can bind to multiple sites on tRNA without changing its conformation, but they can induce tRNA aggregation [ 163 ]. Similarly, Vincristine also can directly interact with tRNA [ 164 ]. The impact of drug-tRNA binding on tRNA aggregation is not yet fully understood.…”

Section: Therapeutic Strategies Via Targeting Trna Methylation Modifi...mentioning

confidence: 99%

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

Yuan,

Zhang,

Lyu

et al. 2024

Cell Death Discov.

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AbstracttRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.

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Section: Therapeutic Strategies Via Targeting Trna Methylation Modifi...mentioning

confidence: 99%