Trividha Snehapaka of Panchagavya Ghrita: A critical comparative evaluation

Abstract

Backgorund:The three stages of Snehapaka formulations namely Mridu, Madhyama and Khara Paka have been characteristically advocated for different routes of administration—Nasya, Pana/Basti and Abhyanga, respectively. Guidelines or established method for post-formulation characterization for the same is hardly available.Objective:The present communication is the comparative study of Mridu, Madhyama and Khara Paka of Panchagavya ghrita (PGG).Materials and Methods:Laboratory prepared samples of PGG following classical method were analyzed for different physicochemical, spectroscopic, chromatographic parameters, and antioxidant activity.Results:No significant difference was found among Mridu, Madhyama and Khara Paka in physicochemical parameters as well as chromatographic profiles. The ratio of absorbance at 240 and 294 nm showed steady increase from Mridu to Madhyama to Khara Paka in the ultraviolet (UV)-visible spectra of unsaponifiable matter. The high performance thin layer chromatography (HPTLC)-2,2 Diphenyl-1-picryl hydrazil (DPPH) bioautography assay revealed presence of two antioxidant compounds in low concentration in all the samples. This was further supported by estimation of total reducing power and DPPH assay. No significant difference was found among the three samples.Conclusion:Comparison of various physicochemical parameters, chromatographic profiles, and in vitro antioxidant activity determination is of little help in establishing any significant difference among the samples. However, spectrophotometric analysis of unsaponifiable matter reveals some encouraging characteristic findings which will be useful in establishing difference among the three stages of processing of PGG as well as Snehapaka in general.

Integrative organic fertilizer immobilized in marine waste derived CaCO3 nanocarrier system towards quality and quantity enhancement of tomato cultivation

“…The unsaponi able matters present in the panchakavya remains the speci c absorbance at around 301 nm which was similarly observed after the crude and vacuum ltered extract of the panchakavya. 29 The combination of hydrophilic panchakavya extract and hydrophobic azadirachtin emulsion in the CaCO 3 nanoparticles was performed in order to optimize the solubility of the nanofertilizer. The fertilizer loading e ciency was found to be 81.4 % for the CaCO 3 nanofertilizer, which con rms the ability of the CaCO 3 nanoparticles as a carrier system for the organic fertilizers panchakavya extract and azadirachtin emulsion.…”

Benefits of Cow Dung - A Human Ignored Gift

“…It is reported for anti-oxidant property having free radical effective in degenerative diseases, cancer, liver diseases, etc. It also acts as a hepatoprotective [60][61][62] .…”