Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes

Si, Longlong; Meng, Kun; Tian, Zhen‐Yu; Sun, Jiaqi; Li, Huiqiang; Zhang, Ziwei; Soloveva, Veronica; Li, Haiwei; Fu, Ge; Xia, Qing; Xiao, Sulong; Zhang, Lihe; Zhou, Demin

doi:10.1126/sciadv.aau8408

Cited by 67 publications

(64 citation statements)

References 42 publications

(77 reference statements)

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“…The virus internalization assay was performed as previously described (Talarico et al, 2005;Si et al, 2018). BHK-21 cells confluent in six-well plates were infected with 500 pfu of viruses on ice.…”

Section: Assay For Virus Internalizationmentioning

confidence: 99%

Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Chen

Wang

et al. 2020

Front. Microbiol.

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The association of Zika virus (ZIKV) infection and severe complications including neurological sequelae especially fetal microcephaly has aroused global attentions since its outbreak in 2015. Currently, there are no vaccines or therapeutic drugs clinically approved for treatments of ZIKV infection, however. And the drugs used for treating ZIKV in pregnant women require a higher safety profile. Here, we identified an anti-asthmatic drug, montelukast, which is of safety profile for pregnant women and exhibited antiviral efficacy against ZIKV infection in vitro and in vivo. And we showed that montelukast could disrupt the integrity of the virions to release the viral genomic RNA, hence irreversibly inhibiting viral infectivity. In consideration of the neuro-protective activity that montelukast possessed, which was previously reported, it is promising that montelukast could be used for patients with ZIKV infection, particularly for pregnant women.

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Section: Assay For Virus Internalizationmentioning

confidence: 99%

Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Chen

Wang

et al. 2020

Front. Microbiol.

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“…It was reported that several types of triterpenoids can exhibit antiviral activities [81][82][83]. Earlier studies highlighted that UNA possesses antiviral potential as well.…”

Section: Antiviral Effectsmentioning

confidence: 99%

Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

Son

Lee

2020

Biomolecules

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Plants have been used as drugs to treat human disease for centuries. Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid extracted from certain medicinal herbs such as Ziziphus jujuba. Since the pharmacological effects and associated mechanisms of UNA are not well-known, in this work, we attempt to introduce the therapeutic potential of UNA with a comparison to ursolic acid (ULA), a well-known secondary metabolite, for beneficial effects. UNA has a keto group at the C-3 position, which may provide a critical difference for the varied biological activities between UNA and ULA. Several studies previously showed that UNA exerts pharmaceutical effects similar to, or stronger than, ULA, with UNA significantly decreasing the survival and proliferation of various types of cancer cells. UNA has potential to exert inhibitory effects in parasitic protozoa that cause several tropical diseases. UNA also exerts other potential effects, including antihyperglycemic, anti-inflammatory, antiviral, and antioxidant activities. Of note, a recent study highlighted the suppressive potential of UNA against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molecular modifications of UNA may enhance bioavailability, which is crucial for in vivo and clinical studies. In conclusion, UNA has promising potential to be developed in anticancer and antiprotozoan pharmaceuticals. In-depth investigations may increase the possibility of UNA being developed as a novel reagent for chemotherapy.

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“…With respect to the physiological function of pentacyclic triterpenoids these compounds are considered as part of a defense system which defends plant against environmental stress, wound and injuries repair mechanism and enhanced the resistance against plant pathogens [12,13]. A variety of infectious organisms were reported inhibited by triterpenoids compounds, including fungi, viruses, bacteria, protozoa and parasites [14]. So, in these senses it has been shown as UA is an efficient antifungal against the infection of apple by Alternaria alternata that could be a useful alternative for this disease management [13].…”

Section: Sift Deskmentioning

confidence: 99%

“…So, in these senses it has been shown as UA is an efficient antifungal against the infection of apple by Alternaria alternata that could be a useful alternative for this disease management [13]. Also, OA and BA exert an inhibitory activity against influenza virus and hepatitis C virus infection binding to viral fusion proteins and disrupting viral entry into the host cells [14]. In root olive tree, pentacyclic triterpenes can be also part of a defense system that protects plant against different agents.…”

Section: Sift Deskmentioning

confidence: 99%

“…As is reported in other plants, these molecules can act avoiding the growth of invasive cells acting on their viability or avoiding the entry of virus inside the cells. These compounds have a non-polar nature that permits its interaction with apolar alpha-helix avoiding the normal effect of its interaction and avoiding the membrane fusion or the normal function of calcium channels [14].…”

Section: Sift Deskmentioning

confidence: 99%

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TIME COURSE PROFILE OF PENTACYCLIC TRITERPENES FROM STEM AND ROOT OF CV. PICUAL OLIVE TREE (Olea europaea, L.) ALONG RIPENING

Peragón¹,

HERNÁNDEZ-YERA²

2020

SDRP-JPS

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Background: Pentacyclic triterpenes are plant secondary metabolites that have many applications for health of the people. Methods: In this work, we determine by a HPLC-UV/Vis and HPLC-MS what pentacyclic triterpenes are found in stem and root of cv. Picual olive tree, a variety typically grown in the area of Jaén (Spain). Moreover, the concentration of these compounds along fruit ripening also has been determined in both organs. Results: Maslinic acid (MA), oleanolic acid (OA), erythrodiol (EO), and uvaol (UO) have been found in stem. OA is the compound that shown the highest concentration in this organ. MA, betulinic acid (BA), OA and ursolic acid have been found in root. In general, BA has the highest concentration in this organ. BA had not been detected in other olive tree organs. Conclusion: The evolution showed by the concentrations of these compounds during ripening suggests the existence of two different phases: the first related with the increment in weight of fruit and the second related with the ripening following. The evolution found in stem is different to the found in root and we believe that are related with the functions of these compounds in each organ.

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Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes

Abstract: Natural triterpenoids, as virus-host fusion inhibitors, exhibit potential in expanding the current repertoire of antiviral agents.

Cited by 67 publications

References 42 publications

Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

TIME COURSE PROFILE OF PENTACYCLIC TRITERPENES FROM STEM AND ROOT OF CV. PICUAL OLIVE TREE (Olea europaea, L.) ALONG RIPENING

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