Triterpenoids from Schleichera oleosa of Darjeeling foothills and their antimicrobial activity

Ghosh, Pradip N.; Chakraborty, Parthasarathi; Mandal, Anurup; Rasul, Mohammed Golam; Chakraborty, M.; Saha, Ajay Krishna

doi:10.4103/0250-474x.91568

Cited by 25 publications

(16 citation statements)

References 4 publications

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“…Penelitian sebelumnya menunjukkan, bahwa ekstrak etanol 70% kulit batang kesambi (Schleichera oleosa Merr) memiliki aktivitas antibakteri terhadap Staphylococcus aureus secara in vitro dengan konsentrasi 6,25% (Fernandez, 2014), triterpenoid dari kulit batang kesambi yaitu taraxerone dan tricadenic acid A memiliki aktivitas antibakteri terhadap Staphylococcus aureus (Ghosh et al, 2011).…”

Section: Staphylococcus Aureus Bersifat Gram Positif Infeksi Stahpylunclassified

Uji Aktivitas Antibakteri Salep Ekstrak Kulit Batang Kesambi (Schleichera oleosa Merr) terhadap Staphylococcus aureus ATCC 25923 yang Diinfeksikan pada Kelinci

Dhego¹,

Susanti²,

Wibawa³

2018

biomedika

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Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri salep ekstrak etanolik kulit batang kesambi (Scheichera oleosa Merr.) dan konsentrasi yang efektif dari salep ekstraknya pada kulit punggung kelinci yang terinfeksi Staphylococcus aureus ATCC 25923. Ekstraksi dilakukan secara maserasi menggunakan pelarut etanol 70%. Formula salep ekstrak kulit batang kesambi dibuat dengan basis hidrokarbon dengan tiga konsentrasi yaitu 6,25%, 12,5% dan 25% dengan salep Gentamicin sebagai kontrol positif. Pengamatan waktu penyembuhan dilakukan dengan cara mengamati lamanya penyembuhan infeksi pada kulit punggung kelinci setelah pemberian salep ekstrak kulit batang kesambi yang ditandai dengan hilangnya eritema dan nanah. Data yang diperoleh dianalisis dengan ANOVA satu jalan (signifikansi p<0,05). Hasil dari penelitian menunjukan bahwa salep ekstrak kulit batang kesambi memiliki efektivitas pada penyembuhan infeksi bakteri Staphylococcus aureus dan terdapat perbedaan efektivitas pada setiap konsentrasi. Konsentrasi salep ekstrak kulit batang kesambi 25% memberikan efek penyembuhan yang lebih efektif dibandingkan dengan konsentrasi 12,5% dan 6,25%.

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Section: Staphylococcus Aureus Bersifat Gram Positif Infeksi Stahpylunclassified

Uji Aktivitas Antibakteri Salep Ekstrak Kulit Batang Kesambi (Schleichera oleosa Merr) terhadap Staphylococcus aureus ATCC 25923 yang Diinfeksikan pada Kelinci

Dhego¹,

Susanti²,

Wibawa³

2018

biomedika

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“…The alkaloids and saponin obtained from this plant were reported to have inhibition activity against E. coli [27]. Less polar compounds like triterpenoids obtained from outer bark of S. oleosa were evaluated for antibacterial potency [28]. However, our work showed that the compounds with stronger antibacterial activity from the bark of S. oleosa were polar in nature and isolation of pure compounds from polar fractions was motivating to get potential antibacterial compounds.…”

Section: Resultsmentioning

confidence: 94%

Brine shrimp lethality and antibacterial activity of extracts from the bark of Schleichera oleosa

Pokhrel¹,

Sharma²,

Bajracharya³

2015

J Coast Life Med

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“…Previous phytochemical studies of S. oleosa fruit showed that it contains terpenoids, flavonoids, tannins, and steroids [16]. From this result suggests that S. oleosa is a good choice for medical used or cosmetic agent against free-radical-associated oxidative damage [17]. Therefore, it can be further subjected to isolate the therapeutic antioxidant compounds activity and evaluate their pharmacologically.…”

Section: Toobpeng Et Almentioning

confidence: 96%

Evaluation of Antioxidant and Antibacterial Activities of Fresh and Freeze-Dried Selected Fruit Juices

Toobpeng

Powthong

Suntornthiticharoen

2017

Asian J Pharm Clin Res

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Objective: The objective of this investigation was to assess the biological activity of fresh fruit juices and freeze dried fruit juices including antioxidant and antibacterial activity. Methods:The fruits used in this study were Schleichera oleosa (Lour.) Oken, Carissa carandas L., and Sandoricum koetjape (Burm.f.) Merr. The fresh juice sample (FJS) was extracted and also prepared for freeze drying sample (FDS) by freeze dryer. The antioxidant capacity of FJS and FDS was assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assays and determination for total phenolic contents (TPCs) by Folin-Ciocalteu's reagent. Antimicrobial tests were carried out by agar diffusion methods and evaluated by measuring the zone of inhibition against 10 isolates of pathogenic bacteria. Results:The highest antioxidant activity of FJS and FDS was found in S. oleosa and related to the scavenging effect on DPPH radical of FJS (100% concentration) and FDS (200 mg/ml) was found in the value of 93.05±0.31% and 82.18±0.33%, respectively. TPC of FJS and FDS from S. oleosa at the same concentration as in the DPPH assay was 1,003.53±1.96 ug GAE/300 g of matter and 827.77±23.15 ug GAE/100 ml of matter, respectively. Both FJS and FDS revealed antibacterial activity. The zone of inhibition of FJS was ranging from 8.3±0.6 to 24.0±1.0 mm and FDS values of 7.3±0.5-21.0±0.9 mm. The most potent sample against bacteria was FJS and FDS from S. oleosa which FJSs against Escherichia coli ESBL and FDS against Pseudomonas aeruginosa MDR2. Conclusion:Fruit juices of S. oleosa, C. carandas, and S. koetjape associated with antioxidant activity in the form of both fresh fruit juices and FDS. The result of this study showed that the value of DPPH and TPCs were slightly decreased in FDS compare with fresh juice. Screening of FJS and FDS of C. carandas revealed broad spectrum antibacterial activity. However, FJS of S. oleosa and S. koetjape showed inhibition of growth of bacteria, but few of FDS from these fruits could inhibit limited bacterial isolates. For antibacterial activity against pathogenic bacteria, the samples of fresh and freeze dried exhibited a different degree of activity.

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Triterpenoids from Schleichera oleosa of Darjeeling foothills and their antimicrobial activity

Cited by 25 publications

References 4 publications

Uji Aktivitas Antibakteri Salep Ekstrak Kulit Batang Kesambi (Schleichera oleosa Merr) terhadap Staphylococcus aureus ATCC 25923 yang Diinfeksikan pada Kelinci

Uji Aktivitas Antibakteri Salep Ekstrak Kulit Batang Kesambi (Schleichera oleosa Merr) terhadap Staphylococcus aureus ATCC 25923 yang Diinfeksikan pada Kelinci

Brine shrimp lethality and antibacterial activity of extracts from the bark of Schleichera oleosa

Evaluation of Antioxidant and Antibacterial Activities of Fresh and Freeze-Dried Selected Fruit Juices

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